Age and Regional Features of Quantitative Indicators of Lymphoid Nodules of the Human Intrahepatic Bile Ducts

Year 2023, Volume: 13 Issue: 3, 170 - 173, 28.12.2023

Naile Aliyeva , Sabina Shadlinskaya

https://doi.org/10.26650/experimed.1297722

Abstract

Objective: This study aimed to elucidate the age and regional characteristics of the quantitative indicators of lymphoid nodules the intrahepatic bile ducts in humans.
Materials and Methods: In our study, the lymphoid structures of the intrahepatic bile duct walls taken from the corpses of 48 people, including newborns, early childhood, puberty, adolescence, adulthood and, elderly were examined. Lymphoid formations were stained using Hellman's method, a macro microscopic method. The digital data obtained during the study were subjected to statistical processing. At the same time, the general recommendations for medical and biological research were observed.
Results: A macro microscopic study of lymphoid formations in the human intrahepatic bile ducts showed that lymphoid formations in the walls of these organs were represented by lymphoid nodules and diffuse lymphoid tissue. Lymphoid formations were determined in the neonatal period and throughout subsequent life. Lymphoid nodules on total preparations were detected as dark (mostly dark blue) structures located against a lighter background of the surrounding organ wall. The peripheral contours of the lymphoid nodules were clearly defined, and the germinal centers were constantly absent. The number of lymphoid nodules was maximal in the lobular ducts and minimal in the common bile duct. This indicator was increased from the neonatal period to early childhood and then gradually decreased.
Conclusion: The results of this study have revealed that lymphoid nodules of the intrahepatic bile ducts acquire maximum development in early childhood. Further, the morphometric parameters of the lymphoid structures gradually decrease, and involutive transformations were noted.

Keywords

Intrahepatic bile ducts, lymphoid nodules, diffuse lymphoid tissue, regional characteristics

References

• 1. Baumann U, Ure B. Biliary atresia. Clin Res Hepatol Gastroenterol 2012; 36(3): 257-59 google scholar
• 2. IOM (Institute of Medicine). Hepatitis and liver cancer: a national strategy for privet control of hepatitis B and C. Washington: National Academies Press. 2010. google scholar
• 3. Dietrich P, Hellerbrand C. Non-alcoholic fatty liver disease, obesity and the metabolic syndrome. Best Pract Res Clin Gastroenterol 2014; 28(4): 637-53. google scholar
• 4. Alswat K, Fallatah H, Al-Judaibi B, Elsiesy H, Al-Hamoudi W Adel N. et al. Qutub Position statement on the diagnosis and management of non-alcoholic fatty liver disease. Saudi Med 2019; 40(6): 531-40. google scholar
• 5. Garg S, Kumar KH, Sahni D, Yadav T, Aggarwal A, Gupta T. Anatomy of the hepatic arteries and their extrahepatic branches in the human liver: A cadaveric study. Ann Anat 2020; 227: 151409. google scholar
• 6. Kruepunga N, Hakvoort T, Hikspoors J, Köhler S, Lamers W. Anatomy of rodent and human livers: What are the differences? Biochim Biophys Acta Mol Basis Dis 2019; 1865(5): 869-78. google scholar
• 7. Lee S, Nodit L. Phyllodes tumor of vulva: a brief diagnostic review. Arch Pathol Lab Med 2014; 138(11): 1546-50. google scholar
• 8. Allahverdiev M. Structural - functional characteristics and patterns of morphogenesis of the glandular and lymphoid apparatuses of the human extrahepatic biliary tract in postnatal ontogenesis. Abstract of diss. doctor of medical sciences. Baku, 2007. google scholar
• 9. Huseynov B. Morphological features of the glands and lymphoid structures of the trachea and main bronchi in humans in postnatal ontogenesis and in the experiment in rats exposed to water procedures with different salt composition. Abstract of diss. doctor of medical sciences. Baku, 2011. google scholar
• 10. Huseynova G. Structural and functional characteristics and features of the morphogenesis of the glands and lymphoid formations of the bladder in postnatal ontogenesis in the norm and in the experiment. Abstract of diss. doctor of medical sciences. Baku, 2013. google scholar
• 11. Shadlinskaya S. Macro microscopic anatomy, regularities of morphogenesis of small glands and lymphoid formations of the vaginal vestibule in human’s postnatal ontogenesis and in experiment. Abstract of diss. doctor of medical sciences. Baku, 2021. google scholar
• 12. Hellman T. Studien uber das lymphoid Gewebe. Beit Path Anat All Pathol 1921; 68: 333-63 google scholar
• 13. Glantz S. Medico-biological statistics. Moscow. Practice .1999. 200p. google scholar
• 14. Borovikov VP. A popular introduction to modern data analysis in the STATISTICA system. Moscow. Telecom. 2015. 288p. google scholar
• 15. Yunusov R. Lymphoid accumulations of the walls of the human trachea and bronchi in postnatal ontogenesis: Abstract of diss. candidate of medical sciences. Andijan. 1988 google scholar