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Conductor of the Astrocyte-Neuron Metabolic Orchestra

Year 2022, , 109 - 128, 01.03.2022

Menizibeya O. Welcome

https://doi.org/10.55262/fabadeczacilik.1078905

Abstract

Disorders such as diabetes mellitus, obesity, Parkinson’s, and Alzheimer’s diseases are characterized by central metabolic dysfunctions and pose an enormous economic burden to public health. Annually, several millions of new cases and deaths are reported worldwide, thus substantiating the need to search for new frontiers in combating the growing prevalence and mortality of these diseases. Over the past few years, scientific evidence has consistently shown that the functional sweet taste receptor, T1R2+T1R3 heterodimer, serves to direct (conduct) peripheral glucose metabolism. Recent data have revealed that this heterodimer can also act as a central glucosensor that conducts cerebral glucose metabolism. Emerging reports have confirmed the central role of this receptor as a driver of glucose metabolism in neurons and astrocytes. In this paper, “metabolic
orchestra” is used to depict the organizational complexity of the plasma membrane receptor-network involved in coordinating glucose transport and metabolism in the astrocyte-neuron circuitry. In light of recent works, suggesting that the taste receptor is a crucial central glucosensor and master coordinator of glucose metabolism, here, the
T1R2+T1R3 heterodimer is referred to as the metabolic conductor of the astrocyte-neuron circuitry, responsible for a highly coordinatedsignaling of glucose molecules and multi-directional cross-talk with other plasma membrane receptors. This concept represents a shift on the astrocyte-neuron metabolic machinery from the GLUT-2 mediated entry of glucose to a more coordinated one, involving multiple players at the plasma membrane. Research focusing on the treatments of brain disorders involving glucose metabolic dysfunctions is also discussed.

Keywords

T1R2+T1R3 cerebral sweet taste receptor antagonists glucosensors metabolic conductor metabolic orchestra cerebral diseases

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Astrosit-Nöron Metabolik Orkestrasının Şefi

Year 2022, , 109 - 128, 01.03.2022

Menizibeya O. Welcome

https://doi.org/10.55262/fabadeczacilik.1078905

Abstract

Diabetes mellitus, obezite, Parkinson ve Alzheimer hastalıkları gibi bozukluklar, merkezi metabolik işlev bozuklukları ile karakterize edilir ve halk sağlığına çok büyük ekonomik yük
oluşturur. Dünya çapında her yıl milyonlarca yeni vaka ve ölüm rapor edilmektedir, bu durum bu hastalıkların artan yaygınlığı ve ölüm oranıyla mücadele etmek için yeni çözümler arayışını ortaya koymaktadır. Son birkaç yıldır bilimsel kanıtlar, tatlı tat almaya yardımcı reseptör T1R2+T1R3 heterodimerinin periferal glukoz metabolizmasını yönlendirmeye hizmet ettiğini tutarlı bir şekilde göstermiştir. Son veriler, bu heterodimerin aynı zamanda serebral glukoz metabolizmasını gerçekleştiren merkezi bir glukosensör görevi gördüğünü ortaya çıkarmıştır. Elde edilen bulgular, bu reseptörün nöronlarda ve astrositlerde glukoz metabolizmasının itici gücü olarak merkezi rolünü doğrulamaktadır. Bu makalede, “metabolik orkestra”, astrosit-nöron devrelerinde glukoz taşınmasını ve metabolizmasını koordine etmede yer alan plazma membran reseptör ağının organizasyonel karmaşıklığını tasvir etmek için kullanılmıştır. Bu derleme, son zamanlarda yapılan çalışmaların ışığında, tat reseptörünün çok önemli bir merkezi glukosensör ve glukoz metabolizmasının ana koordinatörü olduğunu öne sürerek, astrosit-nöron devresinin metabolik iletkeni olarak T1R2+T1R3 heterodimerine atıfta bulunmaktadır; buna göre glukozun hücre içine GLUT-2 aracılı girişinden ziyade plazma zarında astrositnöron metabolik mekanizmasını içeren daha koordineli bir giriş açıklanmaktadır. Ayrıca, glukoz metabolik disfonksiyonlarını içeren beyin bozuklukları için yeni tedavi yolları sağlayabilecek araştırma konuları da tartışılmıştır.

Keywords

TIR2+TIR3 serebral tatlı tat reseptörü antagonistleri glukosensörler metabolik iletken metabolik orkestra beyin hastalıkları

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Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Reviews
Authors

Menizibeya O. Welcome This is me

Publication Date March 1, 2022
Submission Date March 5, 2021
Published in Issue Year 2022

Cite

APA Welcome, M. O. (2022). Conductor of the Astrocyte-Neuron Metabolic Orchestra. Fabad Eczacılık Bilimler Dergisi, 1(47), 109-128. https://doi.org/10.55262/fabadeczacilik.1078905