Leukotriene D4 Levels in Patıents With Breast Cancer

Year 2022, , 331 - 338, 19.10.2022

Sevgi Akaydın , Sümeyye Ramazanoğlu Ece Miser Salihoğlu , Hasan Karanlık , Semra Demokan

https://doi.org/10.55262/fabadeczacilik.1086291

Abstract

Leukotriene D4 (LTD4) is an inflammatory mediator synthesized in the arachidonic acid pathway and has been reported to induce cell proliferation and survival in cancer. LTD4 is synthesized from LTC4 by the enzyme gamma-glutamyltransferase (GGT). Here, we examined serum LTD4 levels and the relationship of LTD4 with GGT in patients with breast cancer. For that purpose, serum samples were taken from 43 patients diagnosed with breast cancer and 8 healthy controls. The patients were divided into five subgroups, as Luminal A, Luminal B, Luminal B-HER2(+), HER2(+) and triple negative. LTD4 levels were measured by ELISA method. Mean levels of LTD4 in the patients were significantly higher than in healthy controls [3,43 (2,21) ng/mL vs 1,47 (0,46) ng/mL; p < 0.05]. According to the molecular subtypes, serum LTD4 levels were found to be significantly higher in the Luminal A, Luminal B and Triple (-) subgroups than in the controls (p <0.01, p <0.005 and p <0.005, respectively). Higher levels of LTD4 have been observed in post-menopausal patients than in pre-menopausal patients (p <0,05). A statistically significant positive correlation was observed between GGT activity and LTD4 levels in the whole study group and post-menopausal patients (R=0.349, p=0.014 and R=0.437, p=0.042, respectively). According to the literature, this study is the first to examine LTD4 levels in breast cancer and supports other studies showing the role of leukotrienes in cancer. Because of LTD4's ability to induce proliferation and inhibit apoptosis, increased levels of LTD4 in our study may be associated with cancer development, especially in post-menopausal women.

Keywords

Leukotriene D4, Gamma-Glutamyltransferase, Breast Cancer, Post-menopausal Status

Project Number

02/2017-02

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