Abstract
References
- Vilhelmova, N., Simeonova, L., Nikolova, N., Pavlova, E., Gospodinova, Z., Antov, G., Galabov, A., & Nikolova, I. (2020). Antiviral, Cytotoxic and Antioxidant Effects of Tanacetum Vulgare L. Crude Extract In Vitro. Folia medica, 62(1), 172– 179. https://doi.org/10.3897/folmed.62.e49370
Effect of n-Hexane Extract from Tanacetum argenteum (Lam.) Willd. subsp. argenteum on the Secretion of Proinflammatory Cytokines in THP-1 Cell Line
Abstract
Inflammation is an initial biological process that involves the activation of the immune system in response to injury, infection or exposure to toxic agents. During this process, cytokines, small proteins produced by immune cells, play a vital role in regulating the immune response. Inflammatory cytokines, including interleukins, tumor necrosis factor-α, nitric oxide, and interferon-gamma, initiate the immune response and promote inflammation. Natural products are frequently a source of potential anti-inflammatory compounds, and screening natural products can lead to the discovery of novel bioactive compounds. The present study aimed to investigate the effects of n-hexane extract from Tanacetum argenteum subsp. argenteum on the lipopolysaccharide-induced inflammatory response in human macrophages THP-1 cell. Cells were incubated with different concentrations of n-hexane extract, and the inhibitor effects of the extract exposure on various cytokine secretions were determined. The findings demonstrated that n-hexane extract dramatically decreased the levels of interleukin‑6, interleukin‑1β, and tumor necrosis factor‑α in differentiated THP-1 cells, indicating the remarkable anti-inflammatory potential of the extract. Furthermore, in silico analysis of toxicogenomic data revealed the interactions between the active component of the n-hexane extract and interleukin-6, interleukin-1β, and tumor necrosis factor.
Keywords
Tanacetum argenteum subsp. argenteum inflammatory response human macrophage cells toxicogenomic data analysis
References
- Vilhelmova, N., Simeonova, L., Nikolova, N., Pavlova, E., Gospodinova, Z., Antov, G., Galabov, A., & Nikolova, I. (2020). Antiviral, Cytotoxic and Antioxidant Effects of Tanacetum Vulgare L. Crude Extract In Vitro. Folia medica, 62(1), 172– 179. https://doi.org/10.3897/folmed.62.e49370
Details
| Primary Language | English |
|---|---|
| Subjects | Toxicology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 26, 2024 |
| Submission Date | December 28, 2023 |
| Acceptance Date | February 27, 2024 |
| Published in Issue | Year 2024 |