Research Article
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Year 2024, Volume: 49 Issue: 1, 51 - 64, 26.03.2024
https://doi.org/10.55262/fabadeczacilik.1300903

Abstract

References

  • Qu, X., Zou, Y., He, C., Zhou, Y. et, al. (2018). Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes. Drug delivery, 25(1), 210-225. doi:10.1080/10717544.2017.1419 513

Formulation and Evaluation of Mixed Micelles Containing Quercetin for Inhibiting Intestinal Metabolism of Atorvastatin

Year 2024, Volume: 49 Issue: 1, 51 - 64, 26.03.2024
https://doi.org/10.55262/fabadeczacilik.1300903

Abstract

Atorvastatin is a poorly bioavailable drug due to fast-pass metabolism. The objective of the study was to prepare quercetin-containing mixed micelles for inhibiting intestinal metabolism of Atorvastatin. Mixed micelles of atorvastatin were prepared using the film hydration method and optimized the formulations were based on different ratios of poloxamer 188 and SDC. The drug permeation and permeability coefficients of mixed micelles were calculated from ex vivo study using goat intestine. To the optimized formulation (F7), quercetin was added to improve the permeability of Atorvastatin. The vesicle size, % entrapment efficiency, and % in vitro drug release of optimized formulation (F7) were found 273.11 nm, 91.34 % and 72.14 %, respectively. The ex vivo results of Atorvastatin with quercetin (25 mg) showed two times more permeation (flux = 2.69 µg/cm2h) and Atorvastatin mixed micelles with quercetin (25 mg) showed three times (flux = 4.33 µg/cm2h ) compared to Atorvastatin without quercetin (flux = 1.34 µg/cm2h). The improvement of Atorvastatin permeation in the form of mixed micelles may be due to the blockage of the p glycoprotein efflux pump in the presence of quercetin. Histopathology study indicated that the formulation changed the microenvironment of tissue when using mixed micelles compared to no significant changes that occurred during control tissue. Based on the obtained results, we can conclude that the mixed micelles containing Atorvastatin enhanced the permeability effect in the presence of quercetin compared to the plain formulation without quercetin.

References

  • Qu, X., Zou, Y., He, C., Zhou, Y. et, al. (2018). Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes. Drug delivery, 25(1), 210-225. doi:10.1080/10717544.2017.1419 513
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Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Research Article
Authors

Narahari N Palei 0000-0002-2041-1849

Jayaraman Rajangam 0000-0002-6367-0365

Ramu Samineni 0000-0002-8652-2883

Arghya Kusum Dhar This is me 0000-0003-1081-9143

Anna Balajı 0000-0002-3233-9637

Publication Date March 26, 2024
Submission Date May 23, 2023
Published in Issue Year 2024 Volume: 49 Issue: 1

Cite

APA Palei, N. N., Rajangam, J., Samineni, R., Dhar, A. K., et al. (2024). Formulation and Evaluation of Mixed Micelles Containing Quercetin for Inhibiting Intestinal Metabolism of Atorvastatin. Fabad Eczacılık Bilimler Dergisi, 49(1), 51-64. https://doi.org/10.55262/fabadeczacilik.1300903