Antifungal Activity of Ethanol Extract Desmanthus virgatus (L.) Leaves In Silico and In Vitro

Year 2025, Volume: 50 Issue: 2, 329 - 342, 26.08.2025

Tukiran Tukiran , Lilik Farkhiyah , Marshellia Ghinanda Dewistamara

Abstract

Most fungal human infections are caused by Candida species, especially Candida albicans. C. albicans is a highly adaptable microorganism that can cause resistance after prolonged exposure to antifungals. C. albicans fungus is easily transmitted so that the discovery of new antifungal agents is very urgent. Therefore, this study aims to find antifungal agents from natural materials, namely wild tantan leaves in silico and in vitro. In the in silico test, 10 dominant compounds from LC-MS results using 2QZX protein obtained 3 compounds that have the most potential as antifungals with binding affinity values lower than ketoconazole. On the other hand, in the in vitro test with the agar diffusion method using disc paper, the average inhibition zone value was 0,01283 m and was classified as strong.

Keywords

Antifungal , wild tantan , Candida albicans , in silico , in vitro

Supporting Institution

the Institute for Research and Community Service, Universitas Negeri Surabaya, INDONESIA

Project Number

Rector's Decree Number: B/42101/UN38.III.1/TU.00.02/2024 on 29 April 2024.

Thanks

Gratitude is expressed to the Institute for Research and Community Service, Universitas Negeri Surabaya, INDONESIA.

References

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