Pathological Complete Response After Imatinib Mesylate Therapy in Inoperabl Gastrointestinal Stromal Tumor: A Case Report

Abstract

Gastrointestinal stromal tumors are characterized by the expression of CD34 and c-kit (CD117) and represent the most common mesenchymal malignancy of the gastrointestinal tract. Imatinib mesylate is small molecule tyrosine kinase inhibitor that suppresses transmembrane receptor c-kit products. Clinical studies for metastatic and inoperabl GISTs have demonstrated partial response rate ranging from 40% to 69% in patients treated with imatinib mesylate. But complete response is rare. We present a 46 year old man patient with unresectable gastrointestinal stromal tumor that has histopatologically proven complete response to imatinib mesylate therapy.

Keywords

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Inoperabl Gastrointestinal Tümörde Imatinib Mesilat Tedavisi Sonrası Patolojik Tam Yanıt: Olgu Sunumu

Abstract

Gastrointestinal stromal tümörler CD34 and c-kit (CD117) ekspresyonu ile karekterize olan, gastrointestinal sistemin en sık görülen mezenkimal maligniteleridir. İmatinib mesiat, transmembran reseptör c-kit ürünlerini baskılayan küçük molekül tirozin kinaz inhibitörüdür. Metastatik ve inoperabl gastarointestinal stromal tümörlerde yapılan klinik çalışmalarda imatinib mesilat tedavisi ile parsiyel yanıt oranları 40% ile 69% arasındadır. Fakat tam yanıt nadirdir. Bu yazımızda 46 yaşında anrezektabl gastrointestinal stromal tümorlü erkek hastada, imatinib mesilat tedavisi ile sağlanan patolojik tam yanıt değerlendirilmiştir.

Keywords

• Gastrointestinal stromal tümor, Imatinib mesylate, Patalojik tam yanıt, Cerrahi

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13. Gönderilme Tarihi: 01.12.2010