Clinical and Demographical Features of The Patients with Multiple Sclerosis Followed in The Upper Part Section of Firat

Abstract

Objective: Multiple sclerosis is the most common cause of neurological disability in young adults after trauma. In this study we analyzed the demographic and clinical features of MS patients in the upper part section of Fırat river between 1997 and 2007. We also evaluated the expanded disability status scale (EDSS) score. Material and Methods: Among 297 patients, 121 patients those known to have definite MS according to 2005 revisions to the McDonald's criteria and those followed up by Neurology Department were included in the study. Demographic data and case-related information were recorded from hospital database. Results: Among these patients 30.6% were males and 69.4% were females. The mean age at onset was 30.41 ±9.4 years. Mean duration of disease was 8.00 ±5.9 years. The presenting symptoms were motor in 32%, sensory in 24%, optic neuritis in 15.7%, brainstem- cerebellar finding 21.5% and other findings in 6.6%. Disease course was defined as relapsing-remitting course in 54.5% of patients, secondary progressive in 28%, primary progressive in 12.3% and benign course in 4.9% of patients. We were recorded familial multiple sclerosis frequency in 11.5%. Conclusion: In this study our results were compared with other studies reported in the literature. Despite the inadequate number of patients enrolled, because these data's are valuable, since this is the first epidemiologic data's of MS patients localized in our region. We hope that our data's will be a guide for further researches.

Keywords

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Yukarı Fırat Bölgesinde Multipl Skleroz Tanısı İle İzlenen Hastaların Klinik ve Demografik Özellikleri

Öz

Amaç: Multipl skleroz genç yetişkinlerde travmadan sonra özürlülüğe sebep olan hastalıkların başında gelir. Bu çalışmada 1997-2007 yılları arasında yukarı Fırat bölgesinde MS'lu hastaların demografik ve klinik özelliklerini inceledik. Ayrıca her hasta için nörolojik takip amaçlı EDSS (expanded disability status scale) skorlamasını değerlendirdik. Gereç ve Yöntem: Nöroloji Bölümünce takip edilen 297 multipl skleroz hastasından, gözden geçirilmiş McDonald tanı kriterlerine göre kesin MS tanısı almış 121 hasta çalışmaya alındı. Demografik veriler ve vaka bilgileri hastane veri tabanından alındı. Bulgular: Hastaların %30.6'sı erkek ve %69.4' ü kadındı. Ortalama başlangıç yaşı 30.41 ± 9.4 idi. Ortalama hastalık süresi 8.00 ± 5.9 yıldı. Başlangıç semptomları hastaların %32'sinde motor, %24'ünde sensoriyel, %15.7'sinde optik nörit, %21.5'inde beyinsapı-serebeller bulgular ve %6.6'sında diğer bulgular izlendi. Hastalığın seyri %54.5 RRMS, %28 SPMS, %12.3 PPMS ve %4.9 BMS olarak tanımlandı. Ailesel MS sıklığı %11.5 olarak kaydedildi. Sonuç: Bu çalışmada elde ettiğimiz bulgular literatürde bildirilen diğer çalışma bulgularıyla karşılaştırılmıştır. Çalışmadaki hasta sayısı yeterli olmamakla birlikte, bölgemizdeki MS hastalarına ait ilk epidemiyolojik veriler olması nedeniyle değerlidir. Verilerimizin başka çalışmalar için yol gösterici olacağını umuyoruz.

Anahtar Kelimeler

• Multipl skleroz, genişletilmiş özürlülük durum skalası (EDSS), epidemiyoloji

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28. Gönderilme Tarihi: 23.10.2010