Craniofacial Mucormycosis: A Case Report

Abstract

Craniofacial-rhinocerebral mucormycosis is a rare and life-threatening invasive fungal infection which results in high mortality. It is most often found in patients with hematologic malignancy, diabetic ketoacidosis, organ transplantation, HIV disease, drug abuse and haemodialysis. Rhinocerebral mucormycosis is the most common form. The patient was admitted to our hospital because of relapsed leukemia. He was treated with salvage chemotherapy with G-CSF support and also treated with antibiotherapy including antifungal agent due to neutropenic fever. He developed a necrotic lesions at nares, hard palate and skin. Craniofacial mucormycosis was diagnosed with physical and histopathologic findings. Although the patient was given an antifungal therapy he didn't improve and died. This case was reported to emphasize the mucormycosis which results in high mortality.

Keywords

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Kraniofasiyal Mukormikoz: Bir Olgu Sunumu

Öz

Kraniofasiyal-rinoserebral mukormikoz yüksek mortaliteye sahip, nadir görülen invaziv bir fungal infeksiyondur. Sıklıkla hamatolojik malignitelerde, diyabetik ketoasidozda, organ transplantasyonlarında, HIV infeksiyonunda, ilaç bağımlılarında ve hemodiyaliz hastalarında görülür. Rinoserebral formu en sık görülen formudur. Hasta relaps akut lösemi tanısıyla tedavi amaçlı yatırıldı. Büyüme faktör(G-CSF) destekli kurtarma kemoterapisi uygulanan hastaya nötropenik ateş nedeniyle antifungal tedavi dahil antibiyotik tedavisi başlandı. İzlemde burunda, sert damakta ve ciltte nekrotik lezyonlar gelişti. Fizik muayene ve histolojik bulgular ile kraniofasiyal mukormikoz olarak teşhis edildi. Ancak antifungal tedaviye rağmen gittikçe kötüleşti ve kaybedildi. Bu olgu yüksek mortaliteyle seyreden mukormikoz infeksiyonlarını vurgulamak için sunuldu.

Anahtar Kelimeler

• Mukor, mukormikoz, lösemi, kraniofasiyal

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