Changes in Lipid Parameters with Added Omega-3 Fatty Acids on Hmg-CoA Reductase Inhibitors in Combined Hyperlipidaemia

Abstract

Objective: Long chain fatty acids especially omega-3 (OM3) fatty acids are very important for protection of cardiac health and fighting against myocardial infarction. We evaluated the effects of OM3 fatty acids added on HMG-CoA reductase inhibitors in patients with combined hyperlipideamia. Materials and Methods: Fifty five patients with coronary artery disease who have combined hyperlipidaemia and thought to be treated with HMG-CoA reductase inhibitors were included. Patients were divided in two groups; atorvastatin 20 mg/day was given to Group A (mean age: 49±5 yrs, n:27, 11 female) and atorvastatin 20mg/day+OM3 fatty acids 3gr/day were given to Group B (mean age: 51±9 yrs, n:28; 13 female) for four weeks. At the end of this period; levels of total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and triglyceride (TG) were measured once more and results were compared. Results: Basal clinical characteristics of the groups were similar (p>0.05). During the follow-up period in group A we saw a significant decrease in TC (28%, p:0.02), LDL (35%, p:0.001), TG (%28, p:0.01) and an insignificant increase in HDL (%5, p:0.067). Patients in group B had 39% decrease in TC (p:0.001), 40% decrease in LDL (p:0.001), 41% decrease in TG (p:0.001) and they had a 19% increase in HDL (p:0.02). By adding OM3; reduction rate in TC and TG levels in group B were significantly higher than the results in Group A (p

Keywords

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Omega-3 Yağ Asitlerinin Hmg-KoA Redüktaz İnhibitörlerine İlave Edilmesiyle Lipid Parametrelerinde Gözlenen Değişiklikler

Öz

Amaç: Ölümcül miyokart enfarktüsüne karşı, kalp sağlığının sürdürülmesi ve korunmasında uzun zincirli, özellikle de omega-3 gibi yağ asitlerinin önemli rol üstlendikleri bildirilmektedir. Çalışmamızda hiperlipidemi nedeniyle HMG-KoA redüktaz inhibitörü başlanan hastalara omega-3 yağ asitlerinin ilave edilmesiyle lipid profilindeki değişiklikler araştırıldı Gereç ve Yöntemler: Çalışmaya, hiperlipidemi nedeniyle HMG-KoA redüktaz inhibitörü başlanması planlanan toplam 55 vaka alındı. Daha sonra 4 hafta süreyle hastaların bir bölümüne (Grup A, yaş ortalaması (YO):49±5 yıl; n:27, 11 kadın) atorvastatin 20 mg/gün, diğer bir bölümüne ise (Grup B, YO:51±9 yıl, n:28, 13 kadın) atorvastatin 20 mg/gün+omega-3 yağ asidi 3gr/gün verildi. Bu sürecin sonunda ise, tüm hastaların total kolesterol (TK), LDL kolesterol, HDL kolesterol (HDL) ve trigliserid (TG) gibi lipid parametreleri tekrar incelenerek gruplar arasında fark olup olmadığı araştırıldı. Bulgular: Grupların bazal klinik özellikleri benzerdi.(P>0,05). Takip süresince; Grup A'daki hastaların TK'de %28 (P:0,02), LDL'de %35 (p:0,001), TG'de %28 (p:0,01) düşme ve HDL'de %5 (p:0,067) artma saptandı. Grup B'deki hastaların TK'de %39 (p:0,001), LDL'de %40 (p.0,001), TG'de %41 (p:0,001) düşme ve HDL'de %19 (p:0,02) artma gözlendi. Tedavi sonrası özellikle Grup-B'de gözlenen TK'de ve TG'de düşme oranı grup A'dan belirgin olarak daha yüksekti (p

Anahtar Kelimeler

• Hiperlipidemi, omega-3 yağ asitleri, HMG-KoA redüktaz inhibitörleri

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14. Kabul Tarihi: 11.04.2009