Relationship Between Trace Element and Oxidative Damage in Patients with Beta-Thalassemia Minor

Abstract

Objective: The aim of the present study was to determine levels of reducted glutathione, activities of catalase and superoxide dismutase, levels of malondialdehyde, concentrations of zinc, copper and iron in patients with beta-thalassemia minor (BTM) compared with healthy subjects, and to evaluate the relationships among these parameters. Materials and Methods: The patients consisted of 35 patients with BTM. The control group consisted of 40 healthy subjects. SOD, CAT, GSH and MDA were measured by biochemical methods. Zn, Cu and Fe levels were determined by flame atomic absorption spectrophotometer. Results: SOD and CAT activities, GSH levels, levels of Fe and Zn, hematocrit, hemoglobin and erythrocyte count in the beta-thalassemia minor subjects were found lower than those in control group (p

Keywords

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Beta Talasemi Minörlü Hastalarda Eser Element ve Oksidatif Hasar İlişkisi

Öz

Amaç: Çalışmanın amacı beta talasemi minörlü (BTM) hasta ve sağlıklı kontrol gruplarında eritrosit redükte glutatyon düzeylerinin, katalaz ve süperoksid dismutaz aktivitelerinin, plazma ve eritrosit malondialdehid düzeylerinin, serum çinko, bakır ve demir konsantrasyonlarının ölçümü, bu parametrelerin birbirleri ile olan ilişkileri her iki grupta karşılaştırmaktır. Gereç ve Yöntem: BTM olan 35 kişilik hasta grubu ile 40 kişilik normal sağlıklı bireyden oluşan kontrol grubunda eritrosit SOD, CAT aktiviteleri, GSH, MDA ve plazma MDA düzeyleri biyokimyasal yöntemlerle ölçüldü. Serum Fe, Cu ve Zn alev atomik absorpsiyon spektrofotometresi ile ölçüldü. Bulgular: Eritrosit SOD ve CAT aktiviteleri, GSH, serum Fe ve Zn düzeyleri, hematokrit, hemoglobin ve eritrosit sayısı hasta grubunda kontrol grubuna göre anlamlı olarak düşük bulundu (p

Anahtar Kelimeler

• Beta talasemi minör, süperoksid dismutaz, katalaz, redükte glutatyon, malondialdehid, çinko, demir, bakır

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29. Kabul Tarihi:11.11.2008