A Inflammatory Breast Carcinoma (Carcinoma Erysipeloides) Case

Abstract

Carcinoma erysipeloides is a rare cutaneouse metastasis, which develops in connection with the malignancies, and it is also known as inflammatory metastatic carcinoma. The development rate of carcinoma eysipeloides in cutaneous metastasis is reported as 3.8%-5.2%. It mostly develops in connection with the breast carcinoma. However, there are some cases caused by carcinoma in malign melanoma, lungs, thyroid, prostate, larynx and gastric adenocarcinoma. A 38-year old female patient, who was diagnosis as invasive ductal carcinoma and undergone a right modified radical mastectomy and took cyclophosphamide, adrimycin and fluorouracil chemotherapy, applied to our policlinic with the complaint of erythema on the operation area and tumescence on the right arm. In the histopathologic examination of the biopsy material taken from the lesions, it was determined that such areas were invasive with the tumor cells of the superficial and deep dermal lenfatics and she was diagnosed as carcinoma erysipeloides. It was continued to the current chemotherapeutical treatment of the patient, but no clinical recovery was achieved.©2008, Firat University, Medical Faculty.

Keywords

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Bir İnflamatuvar Meme Karsinom (Karsinoma Erizipeloides) Olgusu

Öz

Karsinoma erizipeloides (KE), inflamatuvar metastatik karsinom olarak da bilinen, malignensilere bağlı olarak gelisen, nadir görülen bir kutanöz metastazdır. Kutanöz metastazlar içinde karsinoma erizipeloides gelişme oranı %3.8-%5.2 olarak bildirilmiştir. Genellikle meme karsinomlarına bağlı olarak gelişir. Ancak malign melanom, akciğer, tiroid, prostat, larinks ve gastrik adenokarsinomlarının neden olduğu vakalar da mevcuttur. İnvaziv duktal karsinom tanısıyla sağ modifiye radikal mastektomi yapılan, siklofosfamid, adriamisin ve fluorourasil kemoterapisi alan 38 yaşında bayan hasta, operasyon bölgesinde kızarıklık ve sağ kolda şişlik şikayeti ile polikliniğimize başvurdu. Lezyonlardan alınan biyopsi materyalinin histopatolojik incelenmesinde yüzeyel ve derin dermal lenfatiklerin tümör hücreleri ile invaze olduğu görülerek karsinoma erizipeloides tanısı konuldu. Hastanın mevcut kemoterapisine devam edildi ancak klinik düzelme sağlanamadı.©2008, Fırat Üniversitesi, Tıp Fakültesi

Anahtar Kelimeler

• Karsinoma, Karsinoma Erizipeloides, İntraduktal, Meme

References

1. Yu KJ, Lee HE, Ho HC, Lee JC, Chang WC, Hong HS, Yang CH. Carcinoma erysipelatoides from squamous cell carcinoma of unknown origin. International Journal of Clinical Practice. 2005; 59: 1104-1106.
2. Mackie RM. Soft-Tissue Tumors. Champion RH, Burton JL. Burns DA Breathnach SM. eds. Textbook of Dermatology 6th ed. Blachwell science ltd. USA. 2347-2372.
3. Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma: A retrospective study of 7316 cancer patients. J Am Acad Dermatol. 1990; 22: 19-26.
4. Spencer PS, helm TN. Skin metastases in cancer patients. Cutis. 1987; 39: 119-121.
5. Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995;33:161.
6. McLean DI, Haynes HA. Cutaneous manifestation of internal malignant disease. Dermatology in General Medicine'de. Ed. Freedberg IM, Eisen AZ, Wolf K, Austen KF, Goldsmith LA, Fitzpatrick TB. 5'inci baskı. New York, McGraw Hill, 1999; 2106- 2120.
7. White JW. Geriatrics. Evaluating cancer metastatic to the skin. 1985; 40: 67-73.
8. Finkel LJ, Griffiths CE. Inflammatory breast carcinoma (carcinoma erysipeloides): an easily overlooked diagnosis. Br J Dermatol. 1993; 129: 324-326.

9. Nambi R, Tharakaram S. Carcinoma erysipeloides as a presenting feature of breast carcinoma. Int J Dermatol. 1999; 38: 367-368.
10. Cox SE, Cruz PD. A spectrum of inflammatory metastasis to skin via lymphatics:Tree cases of carcinoma erysipeloides. J Am Acad Dermatol 1994; 30: 304-307.
11. Hinrichs R, Kirchberg K, Dissemond J, Hoppe JD, Brenneisen P, Krieg T, Scharffetter-Kochanek K. Carcinoma erysipeloides of the facial skin in a patient with metastatic breast cancer. Br J Dermatol. 1999; 141: 940-941.
12. Lever LR, Holt PJ. Carcinoma erysipeloides. Br J Dermatol. 1991; 124: 279-282.
13. Homler HJ, Goetz CS, Weisenburger DD. Lymphangitic cutaneous metastases from lung cancer mimicking cellulitis. Carcinoma erysipeloides. West J Med. 1986; 144: 610-612.
14. Ikeda Y, Niimi M, Takami H, Kodaira S. Successfully treated carcinoma erysipeloides from gastric cancer. Ann Oncol. 2003; 14: 1328-1329.
15. Yamamura Y, Kodera Y, Kito T. Gastric cancer with carcinoma erysipeloides caused by spontaneous thoracic duct rupture: report of a case. Surg Today. 1997; 27: 166-168.
16. Hamamoto Y, Nagai K, Ichimiya M, Yamamoto K, Kinoshita E, Muto M. Regressive effect of intralesional injection of a moderate dose of recombinant interleukin-2 on carcinoma erysipeloides from gastric carcinoma. Clin Exp Dermatol. 2001; 26: 42-44.
17. Lee SY, Chang SE, Bae GY, Choi JH, Sung KJ, Moon KC, Koh JK. Carcinoma erysipeloides associated with anaplastic thyroid carcinoma. Clinical and Experimental Dermatology. 2001; 26: 671-673.
18. Anadolu R, Anadolu Y. ve ark. ıki olgu nedeniyle karsinoma erizipeloides. XIII. Prof. Dr. A. Lütfü Tat Simpozyumu Posterler kitabı. Ed. Gürgey E. Ankara, Nurol mat.1997; 326-329.
19. Özkan Ş, Bozkurt E. ve ark. Erysipelas melanomatosum. XVI. Ulusal Dermatoloji Kongresi Kitapçığı. Antalya, 1996; 183.
20. Çalka Ö, Metin A, Özen S, Karaayvaz M. Karsinoma Erizipelatoides. Deri Hastalıkları ve Frengi Arşivi. 2002; 1: 64-67.
21. Bottonni U, Innocentzi D, Mannooranparampil TJ. Inflammatory cutaneous metastasis from laryngeal carcinoma. Eur J Dermatol. 2001; 11: 124-126.
22. Kabul Tarihi:13.06.2007