The Efficiency of Omega-3 Fatty Acid (Fish Oil) in Hyperlipidemia Treatment

Abstract

Objectives: Such atherosclerosis-based diseases like coronary artery disease, myocardial infarction, and stroke are leading causes of morbidity and mortality. Hyperlipidemia is among the major risk factors for atherosclerotic diseases and results in accelerated atherosclerosis. Omega-3 fatty acids were reported to favorable effects on lipid profile, inflammation and blood pressure and to reduce rates of mortality associated with cardiovascular diseases. In this study we aimed to examine the effect of omega-3 fatty acid on lipid profile by comparing it with atorvastatin. Materials and Methods: The study registered 41 hyperlipidemic patients. The patients were randomized to two groups: the first group (n=20) was treated with 3 x 500 mg fish oil and the second group (n=21) with 20 mg/day atorvastatin. Serum lipid levels were examined and compared at the beginning of the treatment and in the third month. Results: It was observed that fish oil reduced total cholesterol by 19.2%, LDL by 21.2% and triglyceride by 21.2%, while atorvastatin treatment led to a decrease of 29.8% in total cholesterol, 26.8% in LDL and 25.9% in triglyceride. There was no statistically significant difference between the decreases in serum lipid levels of the groups. Although atorvastatin treatment did not change HDL levels, fish oil treatment brought about an increase in HDL levels. Blood pressures significantly decreased as a result of the treatment in both groups, but the increase in the fish oil group was more pronounced. Conclusion: Fish oil decreases total cholesterol, LDL and particularly triglyceride, levels, while increasing HDL levels. ©2006, Fırat Üniversitesi, Tıp Fakültesi

Keywords

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Hiperlipidemi Tedavisinde Omega-3 Yağ Asitinin (Balık Yağı) Etkinliği

Abstract

Amaç: Koroner arter hastalığı, miyokard infarktüsü, inme gibi ateroskleroz temelli hastalıklar önde gelen morbidite ve mortalite sebepleridir. Hiperlipidemi aterosklerotik hastalıkların majör risk faktörlerindendir ve hızlanmış ateroskleroz ile sonuçlanmaktadır. Omega-3 yağ asitlerinin lipit profili, inflamasyon, kan basıncı üzerine olumlu etkilerinin olduğu ve kardiovasküler hastalıklara bağlı mortalite oranlarını azalttığı rapor edilmiştir. Bu çalışmada omega-3 yağ asidinin lipit profili üzerine etkisini atorvastatin ile karşılaştırarak araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 41 hiperlipidemik hasta alındı. Hastalar randomize olarak iki gruba ayrıldı, birinci grup; 3x500 mg balık yağı (n=20), ikinci grup; 20 mg/gün atorvastatin (n=21) ile tedavi edildi. Çalışma 3 ay sürdü. Tedavinin başlangıcında ve üçüncü aylarında serum lipit düzeylerine bakıldı ve karşılaştırıldı. Bulgular: 3 aylık tedavi sonrasında balık yağı ile total kolesterolde %19,2, LDL-kolesterolde %21,2, trigliseridde %28,7, atorvastatin tedavisi ile total kolesterolde %29,8, LDL-kolesterolde %26,8 ve trigliseridde %25,9 gerileme saptanmış olup her iki tedavinin etkisi bakımından istatistiksel fark bulunamadı. Atorvastatin HDL düzeylerini etkilemezken balık yağı tedavisi ile HDL düzeyinin arttığı gözlendi. Her iki grubun tedavi sonucunda balık yağı grubunda daha fazla olmak üzere kan basınçları anlamlı olarak geriledi. Sonuç: Omega-3 yağ asidi, trigliserid başta olmak üzere total kolesterol, LDL düzeylerini azaltmakta HDL düzeylerini de artırmaktadır. ©2006, Fırat Üniversitesi, Tıp Fakültesi

Keywords

• Hiperlipidemi, balık yağı, atorvastatin

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35. Kabul Tarihi: 23.11.2005