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Correlation Between Findings of Cranial Tomography and the Levels of Cerebrospinal Fluid's Nerve Growth Factor in Hydrocephalic Infants

Year 2013, Volume: 18 Issue: 3, 146 - 150, 01.06.2013

Fatih Serhat Erol Mehmet Birol Öztürk Bekir Akgün Metin Kaplan Hakan Çakın Necip İlhan Selami Serhatlıoğlu

Abstract

Objective: To investigate the correlation between the NGF levels in the CSF and brain tomography indexes in preoperative and postoperative evaluations of hydrocephalic infants undergoing ventriculoperitoneal shunt. Material and Method: A total of 27 patients were included. CSF samples were obtained in the during the operation and on the 3rd and 30th postoperative days, and CT evaluations were performed. Results: No correlation was found between the NGF levels in CSF and CCT indexes using the Spearman correlation. The increases of NGF levels on the 3rd postoperative day were significantly higher than those of the peroperative levels (p

Keywords

Cerebrospinal fluid Computerized cranial tomography Hydrocephalus Nerve growth factor.

References

  • Mataro M, Poca MA, Sahuquillo J, et al. Cognitive changes after cerebrospinal fluid shunting in young adults with spina bifida and assumed arrested hydrocephalus. J Neurol Neurosurg Psychiatry 2000; 68: 615-21.
  • Yang JT, Chang C, Hsu H, et al. Increase in CSF NGF concentration is positively correlated with poor prognosis of postoperative hydrocephalic patients. Clin Biochem 1999; 32: 673-7
  • LeMay M, Hochberg FH. Ventricular differences between hydrostatic hydrocephalus and hydrocephalus ex vacuo by CT. Neuroradiol 1979; 17: 191-95.
  • Erol FS, Yakar H, Artas H, et al. Investigating a correlation between the results of transcranial Doppler and the level of nerve growth factor in cerebrospinal fluid of hydrocephalic infants: clinical study. Pediatr Neurosurg 2009; 45: 192-7.
  • Mashayekhi F, Salehi Z. Expression of nerve growth factor in cerebrospinal fluid of congenital hydrocephalic and normal children. Eur J Neurol 2005; 12: 632-37.
  • Sofroniew MV, Howe CL, Mobley WC. Nerve growth factors signalling, neuroprotection and neural repair. An Rev Neurosci 2001; 24: 1217-81.
  • Suzaki I, Hara T, Tanaka C, et al. Elevated nerve growth factor levels in cerebrospinal fluid associated with progressive cortical atrophy. Neuropediatr 1997; 28: 268-71.
  • Lu B, Yokoyama M, Dreyfus CF, et al. NGF gene expression in actively growing brain glia. J Neurosci 1991; 11: 318-26.
  • Kulkarni AV, Drake JM, Armstrong DC, et al. Imaging correlates of successful endoscopic third ventriculostomy. J Neurosurg 2000; 92: 915-19.
  • Schwartz TH, Ho B, Prestigiacomo CJ, et al. Ventricular volume following third ventriculostomy. J Neurosurg 1999; 91: 20-5.
  • Meier U, Mutze S. Does the ventricle size change after shunt operation of normal–pressure hydrocephalus? Acta Neurochir Suppl 2005; 95: 257-59.
  • Eide PK. Quantitative analysis of continuous intracranial pressure recordings in symptomatic patients with extracranial shunts. J Neurol Neurosurg Psychiatry 2003; 74: 231-37.
  • Fouyas IP, Casey AT, Thompson D, et al. Use of intracranial pressure monitoring in the management of childhood hydrocephalus and shunt-related problems. Neurosurg 1996; 38: 726
  • Liechty EA, Gilmor RL, Bryson CQ, et al. Outcome of highrisk neonates with ventriculomegaly. Dev Med Child Neurol 1983; 252: 162-68.
  • Low JA, Galbraith RS, Sauerbrei EE, et al. Motor and cognitive development of infants with intraventricular hemorrhage, ventriculomegaly or periventricular parenchimal lesions. Am J Obstet Gynecol 1986; 155: 750-56.

Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki

Year 2013, Volume: 18 Issue: 3, 146 - 150, 01.06.2013

Fatih Serhat Erol Mehmet Birol Öztürk Bekir Akgün Metin Kaplan Hakan Çakın Necip İlhan Selami Serhatlıoğlu

Abstract

Amaç: Ventriküloperitoneal şant uygulanan hidrosefalili bebeklerin ameliyat öncesi ve sonrası değerlendirilmelerinde Beyin Omurilik Sıvısı Sinir Büyüme Faktörü (BOS NGF) düzeyleri ve beyin tomografisi endeksleri arasındaki ilişkiyi araştırmak. Gereç ve Yöntem: Toplam 27 hasta dahil edildi. BT incelemeleri yapıldı ve BOS örnekleri ameliyat sırasında ve ameliyat sonrası 3. ve 30. günlerde alındı. Bulgular: Spearman korelasyonu ile Bilgisayarlı beyin tomografisi (BBT) endekslerinde ve BOS NGF düzeyleri arasında korelasyon bulunamadı. Ameliyat sonrası 3. gün, NGF düzeyi ameliyat öncesi düzeylerine göre anlamlı olarak yüksek bulundu ( p

Keywords

Beyin omurilik sıvısı Bilgisayarlı beyin tomografisi Hidrosefali Sinir büyüme faktörü.

References

  • Mataro M, Poca MA, Sahuquillo J, et al. Cognitive changes after cerebrospinal fluid shunting in young adults with spina bifida and assumed arrested hydrocephalus. J Neurol Neurosurg Psychiatry 2000; 68: 615-21.
  • Yang JT, Chang C, Hsu H, et al. Increase in CSF NGF concentration is positively correlated with poor prognosis of postoperative hydrocephalic patients. Clin Biochem 1999; 32: 673-7
  • LeMay M, Hochberg FH. Ventricular differences between hydrostatic hydrocephalus and hydrocephalus ex vacuo by CT. Neuroradiol 1979; 17: 191-95.
  • Erol FS, Yakar H, Artas H, et al. Investigating a correlation between the results of transcranial Doppler and the level of nerve growth factor in cerebrospinal fluid of hydrocephalic infants: clinical study. Pediatr Neurosurg 2009; 45: 192-7.
  • Mashayekhi F, Salehi Z. Expression of nerve growth factor in cerebrospinal fluid of congenital hydrocephalic and normal children. Eur J Neurol 2005; 12: 632-37.
  • Sofroniew MV, Howe CL, Mobley WC. Nerve growth factors signalling, neuroprotection and neural repair. An Rev Neurosci 2001; 24: 1217-81.
  • Suzaki I, Hara T, Tanaka C, et al. Elevated nerve growth factor levels in cerebrospinal fluid associated with progressive cortical atrophy. Neuropediatr 1997; 28: 268-71.
  • Lu B, Yokoyama M, Dreyfus CF, et al. NGF gene expression in actively growing brain glia. J Neurosci 1991; 11: 318-26.
  • Kulkarni AV, Drake JM, Armstrong DC, et al. Imaging correlates of successful endoscopic third ventriculostomy. J Neurosurg 2000; 92: 915-19.
  • Schwartz TH, Ho B, Prestigiacomo CJ, et al. Ventricular volume following third ventriculostomy. J Neurosurg 1999; 91: 20-5.
  • Meier U, Mutze S. Does the ventricle size change after shunt operation of normal–pressure hydrocephalus? Acta Neurochir Suppl 2005; 95: 257-59.
  • Eide PK. Quantitative analysis of continuous intracranial pressure recordings in symptomatic patients with extracranial shunts. J Neurol Neurosurg Psychiatry 2003; 74: 231-37.
  • Fouyas IP, Casey AT, Thompson D, et al. Use of intracranial pressure monitoring in the management of childhood hydrocephalus and shunt-related problems. Neurosurg 1996; 38: 726
  • Liechty EA, Gilmor RL, Bryson CQ, et al. Outcome of highrisk neonates with ventriculomegaly. Dev Med Child Neurol 1983; 252: 162-68.
  • Low JA, Galbraith RS, Sauerbrei EE, et al. Motor and cognitive development of infants with intraventricular hemorrhage, ventriculomegaly or periventricular parenchimal lesions. Am J Obstet Gynecol 1986; 155: 750-56.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Fatih Serhat Erol This is me

Mehmet Birol Öztürk This is me

Bekir Akgün This is me

Metin Kaplan This is me

Hakan Çakın This is me

Necip İlhan This is me

Selami Serhatlıoğlu This is me

Publication Date June 1, 2013
Published in Issue Year 2013 Volume: 18 Issue: 3

Cite

APA Erol, F. S., Öztürk, M. B., Akgün, B., Kaplan, M., et al. (2013). Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki. Fırat Tıp Dergisi, 18(3), 146-150.
AMA Erol FS, Öztürk MB, Akgün B, Kaplan M, Çakın H, İlhan N, Serhatlıoğlu S. Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki. Fırat Tıp Dergisi. June 2013;18(3):146-150.
Chicago Erol, Fatih Serhat, Mehmet Birol Öztürk, Bekir Akgün, Metin Kaplan, Hakan Çakın, Necip İlhan, and Selami Serhatlıoğlu. “Hidrosefalik İnfantlarda Kranial Tomografi Bulguları Ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki”. Fırat Tıp Dergisi 18, no. 3 (June 2013): 146-50.
EndNote Erol FS, Öztürk MB, Akgün B, Kaplan M, Çakın H, İlhan N, Serhatlıoğlu S (June 1, 2013) Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki. Fırat Tıp Dergisi 18 3 146–150.
IEEE F. S. Erol, M. B. Öztürk, B. Akgün, M. Kaplan, H. Çakın, N. İlhan, and S. Serhatlıoğlu, “Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki”, Fırat Tıp Dergisi, vol. 18, no. 3, pp. 146–150, 2013.
ISNAD Erol, Fatih Serhat et al. “Hidrosefalik İnfantlarda Kranial Tomografi Bulguları Ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki”. Fırat Tıp Dergisi 18/3 (June 2013), 146-150.
JAMA Erol FS, Öztürk MB, Akgün B, Kaplan M, Çakın H, İlhan N, Serhatlıoğlu S. Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki. Fırat Tıp Dergisi. 2013;18:146–150.
MLA Erol, Fatih Serhat et al. “Hidrosefalik İnfantlarda Kranial Tomografi Bulguları Ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki”. Fırat Tıp Dergisi, vol. 18, no. 3, 2013, pp. 146-50.
Vancouver Erol FS, Öztürk MB, Akgün B, Kaplan M, Çakın H, İlhan N, Serhatlıoğlu S. Hidrosefalik İnfantlarda Kranial Tomografi Bulguları ve Beyin Omurilik Sıvısı Sinir Büyüme Faktörü Arasındaki İlişki. Fırat Tıp Dergisi. 2013;18(3):146-50.