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Ethyleneglycol Intoxication in a Patient Drunk Antifreeze: A Case Report

Year 2012, Volume: 17 Issue: 3, 182 - 184, 01.06.2012

İsmail Demirel Levent Avcı Güneri Atalan Aykut Urfalıoğlu Gonca Çağlar Toprak

Abstract

Ethyleneglycol (EG) poisoning is a very rare type of intoxication in our country. EG belongs to the group of dihydric alcohol, a colourless, odourless, sweet tasting fluid. Intake of EG, either accidentally or suicide attempt, is characterised by severe metabolic acidosis, depression of central nervous system and acute renal failure. We reported here a case with severe metabolic acidosis, coma and acute renal failure due to suicidal intake of EG.

Keywords

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References

  • Linden CH, Lovejoy FH. Poisoning and drug overdosage. In: Fauci A, Braunwald E, Isselbacher K, Wilson J, Martin J (eds). Harrison's Principles of Internal Medicine. 14th ed. New York: The McGraw- Hill Companies, 1998; 2534-35.
  • Robertson WO. Common poisoning. In: Wyngaarden JB, Smith LH, Bennett JC (eds). Cecil Textbook of Medicine. 19th ed., Philadelphia: W. B. Saunders Company, 1992; 113.
  • Schauben J. Methanol and ethylene glycol toxicity. US Pharmacist 1998; 23: 22-3.
  • Barceloux DG, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol 1999; 37: 537-60.
  • Davis DP, Bramwell KJ, Hamilton RS, Williams SR. Ethylene glycol poisoning: case report of a record-high level and a review. J Emerg Med 1997; 15: 653-67.
  • Zimina LN, Budarina IS, Nazarenko AF. Morphologic changes in the liver and kidney in ethyleneglycol poisoning. Arkh Patol 1977; 39: 51-8.
  • Khan SR, Glenton PA, Byer KJ. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline. Kidney Int 2006; 70: 914-23.
  • Kaiser N, Reiger I, Foidl E, Berek K, Baumgartl P. Ethyleneglicol intoxication in a dipsomaniac patient. Nephrol Dial Transplant 1997; 12: 1753-4.
  • Gallyas F, Jaray J, Csata S. Acute renal failure following ethyleneglycol poisoning. Report of three successfully treated cases. Acta Chir Acad Sci Hung 1971; 12: 225-8.
  • Jabobsen D, McMartin KE. Antidotes for methanol and ethylene glycol poisoning. J Toxicol 1997; 35: 127-43.
  • Hall TL. Fomepizole in the treatment of ethylene glycol poisoning. CJEM 2002; 49: 130-7.
  • Frommer JP, Ayus JC. Acute ethylene glycol intoxication. Am J Nephrol 1982; 2: 1-5.

Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu

Year 2012, Volume: 17 Issue: 3, 182 - 184, 01.06.2012

İsmail Demirel Levent Avcı Güneri Atalan Aykut Urfalıoğlu Gonca Çağlar Toprak

Abstract

Etilenglikol (EG) zehirlenmesi ülkemizde çok nadir rastlanan zehirlenmelerdendir. EG, dihidrik alkoller grubundan, renksiz, kokusuz, tatlı ve suda çözünen bir maddedir. Kaza yada suisid amaçlı olarak alınması sonucu, şiddetli metabolik asidoz, santral sinir sistemi depresyonu ve akut böbrek yetmezliği ile giden zehirlenme tablosu ortaya çıkar. Suisid amaçlı antifriz içtikten sonra EG zehirlenmesine bağlı olarak ağır metabolik asidoz, koma ve akut böbrek yetmezliği tablosu gelişmiş bir olguyu sunduk.

Keywords

Etilenglikol zehirlenmesi Metabolik asidoz Akut böbrek yetmezliği

References

  • Linden CH, Lovejoy FH. Poisoning and drug overdosage. In: Fauci A, Braunwald E, Isselbacher K, Wilson J, Martin J (eds). Harrison's Principles of Internal Medicine. 14th ed. New York: The McGraw- Hill Companies, 1998; 2534-35.
  • Robertson WO. Common poisoning. In: Wyngaarden JB, Smith LH, Bennett JC (eds). Cecil Textbook of Medicine. 19th ed., Philadelphia: W. B. Saunders Company, 1992; 113.
  • Schauben J. Methanol and ethylene glycol toxicity. US Pharmacist 1998; 23: 22-3.
  • Barceloux DG, Krenzelok EP, Olson K, Watson W. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. J Toxicol Clin Toxicol 1999; 37: 537-60.
  • Davis DP, Bramwell KJ, Hamilton RS, Williams SR. Ethylene glycol poisoning: case report of a record-high level and a review. J Emerg Med 1997; 15: 653-67.
  • Zimina LN, Budarina IS, Nazarenko AF. Morphologic changes in the liver and kidney in ethyleneglycol poisoning. Arkh Patol 1977; 39: 51-8.
  • Khan SR, Glenton PA, Byer KJ. Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline. Kidney Int 2006; 70: 914-23.
  • Kaiser N, Reiger I, Foidl E, Berek K, Baumgartl P. Ethyleneglicol intoxication in a dipsomaniac patient. Nephrol Dial Transplant 1997; 12: 1753-4.
  • Gallyas F, Jaray J, Csata S. Acute renal failure following ethyleneglycol poisoning. Report of three successfully treated cases. Acta Chir Acad Sci Hung 1971; 12: 225-8.
  • Jabobsen D, McMartin KE. Antidotes for methanol and ethylene glycol poisoning. J Toxicol 1997; 35: 127-43.
  • Hall TL. Fomepizole in the treatment of ethylene glycol poisoning. CJEM 2002; 49: 130-7.
  • Frommer JP, Ayus JC. Acute ethylene glycol intoxication. Am J Nephrol 1982; 2: 1-5.
There are 12 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

İsmail Demirel This is me

Levent Avcı This is me

Güneri Atalan This is me

Aykut Urfalıoğlu This is me

Gonca Çağlar Toprak This is me

Publication Date June 1, 2012
Published in Issue Year 2012 Volume: 17 Issue: 3

Cite

APA Demirel, İ., Avcı, L., Atalan, G., Urfalıoğlu, A., et al. (2012). Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu. Fırat Tıp Dergisi, 17(3), 182-184.
AMA Demirel İ, Avcı L, Atalan G, Urfalıoğlu A, Toprak GÇ. Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu. Fırat Tıp Dergisi. June 2012;17(3):182-184.
Chicago Demirel, İsmail, Levent Avcı, Güneri Atalan, Aykut Urfalıoğlu, and Gonca Çağlar Toprak. “Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu”. Fırat Tıp Dergisi 17, no. 3 (June 2012): 182-84.
EndNote Demirel İ, Avcı L, Atalan G, Urfalıoğlu A, Toprak GÇ (June 1, 2012) Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu. Fırat Tıp Dergisi 17 3 182–184.
IEEE İ. Demirel, L. Avcı, G. Atalan, A. Urfalıoğlu, and G. Ç. Toprak, “Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu”, Fırat Tıp Dergisi, vol. 17, no. 3, pp. 182–184, 2012.
ISNAD Demirel, İsmail et al. “Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu”. Fırat Tıp Dergisi 17/3 (June 2012), 182-184.
JAMA Demirel İ, Avcı L, Atalan G, Urfalıoğlu A, Toprak GÇ. Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu. Fırat Tıp Dergisi. 2012;17:182–184.
MLA Demirel, İsmail et al. “Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu”. Fırat Tıp Dergisi, vol. 17, no. 3, 2012, pp. 182-4.
Vancouver Demirel İ, Avcı L, Atalan G, Urfalıoğlu A, Toprak GÇ. Antifriz İçen Bir Hastada Etilenglikol Zehirlenmesi: Olgu Sunumu. Fırat Tıp Dergisi. 2012;17(3):182-4.