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The Effect Of Hemoglobin Variant On HbA1c Measurement

Year 2011, Volume: 16 Issue: 2, 97 - 99, 01.04.2011

Berrak Güven Murat Can Zeynep Eskici

Abstract

HbA1c test is used in diagnosis and monitoring of diabetes mellitus. In this case report, a patient was presented that had discordance between clinical status and HbA1c result. Further investigations showed asymptomatic hemoglobin variant was caused this discordance.

Keywords

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References

  • American Diabetes Association Clinical Practice Recommendation. Tests of glycemia in diabetes. Diabetes Care 2003; 26: 106–108.
  • American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2010; 33: 11-61.
  • Sacks DB. Carbohydrates. In: Burtis CA, Ashwood ER, Bruns D.E (Editors).Tietz textbook of clinical chemistry and molecular diagnostics, 4rd ed. Philadelphia: WB Saunders, 2006: 879-884.
  • Little RR, and Roberts W L, A Review of variant hemoglobins interfering with hemoglobin A1c measurement. J Diabetes Sci Technol 2009; 3: 446- 451.
  • Onat A, Hergenç G, Uyarel H, Can G, Ozhan H. Prevalence, incidence, predictors and outcome of type 2 diabetes in Turkey. Anadolu Kardiyol Derg 2006; 6: 314-321.
  • Cürük MA, Zeren F, Genç A ve ark. Prenatal diagnosis of sickle cell anemia and beta-thalassemia in southern Turkey. Hemoglobin 2008; 32: 525-530.
  • Sacks DB. Hemoglobin variants and hemoglobin A1c analysis: problem solved? Clin Chem 2003; 49: 1245– 1247.
  • Tran DV, Lyon AW, Higgins TN, et al. Use of serial patient hemoglobin A1c differences to determine long- term imprecision of immunoassay and high- performance liquid chromatography analyzers. J Diabetes Sci Technol 2009; 3: 424-428.
  • Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ. Hemoglobin variants and determination of glycated hemoglobin (HbA1c). Diabetes Metab Res Rev 2001; 17: 94–98.
  • Bry L, Chen PC, Sacks DB. Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin Clin Chem 2001; 47: 153–163.
  • Camargo JL, Gross JL. Conditions associated with very low values of glycohaemoglobin measured by an HPLC method. J Clin Pathol 2004; 57: 346-349.
  • Chu CH, Lam HC, Lee JK, et al. Common hemoglobin variants in southern Taiwan and their effect on the determination of HbA1c by ion-exchange high- performance liquid chromatography. J Chin Med Assoc 2009; 72: 362-367.
  • Gönderilme Tarihi: 29.07.2010

Hemoglobin Varyantının HbA1c Ölçümüne Etkisi

Year 2011, Volume: 16 Issue: 2, 97 - 99, 01.04.2011

Berrak Güven Murat Can Zeynep Eskici

Abstract

HbA1c testi diabetes mellitusun tanısı ve takibinde kullanılmaktadır. Bu olgu sunumunda, klinik ile uyumsuz HbA1c sonucuna sahip bir hasta sunulmuştur. İleri araştırmalar asemptomatik hemoglobin varyantının bu uyumsuzluğa neden olduğunu göstermiştir.

Keywords

-

References

  • American Diabetes Association Clinical Practice Recommendation. Tests of glycemia in diabetes. Diabetes Care 2003; 26: 106–108.
  • American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2010; 33: 11-61.
  • Sacks DB. Carbohydrates. In: Burtis CA, Ashwood ER, Bruns D.E (Editors).Tietz textbook of clinical chemistry and molecular diagnostics, 4rd ed. Philadelphia: WB Saunders, 2006: 879-884.
  • Little RR, and Roberts W L, A Review of variant hemoglobins interfering with hemoglobin A1c measurement. J Diabetes Sci Technol 2009; 3: 446- 451.
  • Onat A, Hergenç G, Uyarel H, Can G, Ozhan H. Prevalence, incidence, predictors and outcome of type 2 diabetes in Turkey. Anadolu Kardiyol Derg 2006; 6: 314-321.
  • Cürük MA, Zeren F, Genç A ve ark. Prenatal diagnosis of sickle cell anemia and beta-thalassemia in southern Turkey. Hemoglobin 2008; 32: 525-530.
  • Sacks DB. Hemoglobin variants and hemoglobin A1c analysis: problem solved? Clin Chem 2003; 49: 1245– 1247.
  • Tran DV, Lyon AW, Higgins TN, et al. Use of serial patient hemoglobin A1c differences to determine long- term imprecision of immunoassay and high- performance liquid chromatography analyzers. J Diabetes Sci Technol 2009; 3: 424-428.
  • Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ. Hemoglobin variants and determination of glycated hemoglobin (HbA1c). Diabetes Metab Res Rev 2001; 17: 94–98.
  • Bry L, Chen PC, Sacks DB. Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin Clin Chem 2001; 47: 153–163.
  • Camargo JL, Gross JL. Conditions associated with very low values of glycohaemoglobin measured by an HPLC method. J Clin Pathol 2004; 57: 346-349.
  • Chu CH, Lam HC, Lee JK, et al. Common hemoglobin variants in southern Taiwan and their effect on the determination of HbA1c by ion-exchange high- performance liquid chromatography. J Chin Med Assoc 2009; 72: 362-367.
  • Gönderilme Tarihi: 29.07.2010
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Berrak Güven This is me

Murat Can This is me

Zeynep Eskici This is me

Publication Date April 1, 2011
Published in Issue Year 2011 Volume: 16 Issue: 2

Cite

APA Güven, B., Can, M., & Eskici, Z. (2011). Hemoglobin Varyantının HbA1c Ölçümüne Etkisi. Fırat Tıp Dergisi, 16(2), 97-99.
AMA Güven B, Can M, Eskici Z. Hemoglobin Varyantının HbA1c Ölçümüne Etkisi. Fırat Tıp Dergisi. April 2011;16(2):97-99.
Chicago Güven, Berrak, Murat Can, and Zeynep Eskici. “Hemoglobin Varyantının HbA1c Ölçümüne Etkisi”. Fırat Tıp Dergisi 16, no. 2 (April 2011): 97-99.
EndNote Güven B, Can M, Eskici Z (April 1, 2011) Hemoglobin Varyantının HbA1c Ölçümüne Etkisi. Fırat Tıp Dergisi 16 2 97–99.
IEEE B. Güven, M. Can, and Z. Eskici, “Hemoglobin Varyantının HbA1c Ölçümüne Etkisi”, Fırat Tıp Dergisi, vol. 16, no. 2, pp. 97–99, 2011.
ISNAD Güven, Berrak et al. “Hemoglobin Varyantının HbA1c Ölçümüne Etkisi”. Fırat Tıp Dergisi 16/2 (April 2011), 97-99.
JAMA Güven B, Can M, Eskici Z. Hemoglobin Varyantının HbA1c Ölçümüne Etkisi. Fırat Tıp Dergisi. 2011;16:97–99.
MLA Güven, Berrak et al. “Hemoglobin Varyantının HbA1c Ölçümüne Etkisi”. Fırat Tıp Dergisi, vol. 16, no. 2, 2011, pp. 97-99.
Vancouver Güven B, Can M, Eskici Z. Hemoglobin Varyantının HbA1c Ölçümüne Etkisi. Fırat Tıp Dergisi. 2011;16(2):97-9.