Granular cell tumor of the Urinary bladder: Case Report

Year 2010, Volume: 15 Issue: 4, 207 - 209, 01.08.2010

Dalia Hammoud Mazen Shaheen Lisa Le Chimezie Amanambu

Abstract

Granular cell tumors (GCT) are extremely rare lesions of the urinary bladder with only 12 cases have been reported in the literature. Although usually benign, these lesions are commonly confused for malignant tumors since they may present as solid tumors with ill defined margins and ulcerating surface and hence could be confused with transitional, squamous cell carcinoma or sarcoma in the urinary bladder. Only two cases of malignant granular cell tumor of the urinary bladder were reported. A careful pathologic assessment for establishing the appropriate diagnosis is required and the treatment is either a conservative or aggressive surgical treatment for benign or localized malignant GCT of the urinary bladder, respectively. We report the case of a forty six year old patient who had benign GCT of the urinary bladder.

Keywords

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İdrar Kesesinin Granüler hücreli tümörü: Olgu Sunumu

Abstract

Granüler hücreli tümörler (GHT) literatürde sadece 12 adet olgu sunumu ile belirtilmiş olan idrar kesesinin oldukça nadir görülen lezyonlarıdır. Genellikle iyi huylu olmalarına rağmen bu tümörler kötü huylu tümörler ile karışabilir. Çünkü bu lezyonlar idrar kesesinde sarkom veya transizyonel skuamöz hücreli kanseri ile karışabildiklerinden dolayı yüzeyleri ülserleşmiş ve sınırları düzensiz solid tümörler olarak görülebilir. İdrar yollarının kötü huylu granüler hücreli tümörü sadece iki olguda bildirilmiştir. Uygun tanıyı koyabilmek için dikkatli bir patolojik değerlendirme gereklidir. İyi huylu tümörlerin tedavisi semptomatik koruyucu tedavi iken, kötü huylu tümörlerin tedavisi cerrahidir. İdrar kesesinde iyi huylu granüler hücreli tümörü olan kırk altı yaşındaki bir hastayı olgu sunumu olarak bildiriyoruz.

Keywords

Granüler hücreli tümör, idrar kesesi, S100 proteini, immünohistokimya

References

• Victoria LV, Hoffman HT, Robinson RA. Granular cell tumor of the larynx. J Laryngol Otol. 1998; 112: 373-376.
• Abrikossof A. Ueber Myome ausgehened von der quergestreiften willkuerlichen Muskulatur. Virchows Arch (Patho Anat). 1926; 260: 215-217.
• Mouradian JA, Coleman JW, McGovern JH et al. Granular cell tumor (Myoblastoma) of the bladder. J Urol. 1974; 112: 343345.
• Sobel HJ, Schwarz R, Marquet R. Light and electron microscope study of the origin of granular cell myoblastoma. J Pathol. 1973; 109: 101-111.
• Fanburg-Smith JC, Meis-Kindblom JM, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. Jul 1998; 22; 779-794.
• Ravich A, Stout AP, Ravich RA. Malignant granular cell myoblastoma involving the urinary bladder. Ann Surg. 1945; 121: 361-363.
• Abbas F, Memon A, Siddiqui T, et al. World J Surg Oncol. 2007 Mar 13; 5: 33.
• LeBoit PE, Barr RJ, Burall S, et al. Primitive polypoid granular cell tumor and other cutaneous granular cell neoplasms of apparent non neural origin. Am J Surg Pathol. 1991; 15: 48-58.
• Scheithauer BW, Woodruff JM, Erlandson RA. Benign granular cell tumors and malignant granular cell tumors. In: Tumors of the Peripheral Nervous System, Atlas of Tumor Pathology. 3rd ed. Washington, DC: Armed Forces Institute of Pathology; 1997:248; 259: 358-365.
• Bellezza G, Colella R, Sidoni A, et al. Immunohistochemical expression of Galectin-3 and HBME-1 in granular cell tumors: a new finding. Histol Histopathol. Sep 2008; 23: 1127-1130.
• Moscovic EA, Azar HA. Multiple granular cell tumors. Case report with electron microscopic observations and review of the literature. Cancer. 1967; 20: 2032-2047.
• Seo IS, Azzarelli B, Warner TF, et al. Multiple visceral and cutaneous granular cell tumors. Ultrastructural and immunocytochemical evidence of Schwann cell origin. Cancer. 1984; 53: 2104-2110.
• Ordonez NG. Granularcell tumor: a review and update. Adv Anat Pathol 1999; 6: 186-203.
• Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1988; 22: 779-794.
• Rosai, editor. Ackerman's, Surgical pathology. Philadelphia, Mosby; 2004. Soft tissues chapter; pp. 2237-2371.
• Enzinger and Weiss's Soft Tissue Tumors. Philadelphia, Mosby; 2001. Benign tumors of peripheral nerves chapter; pp. 11111207.