Giant-Cell Tumor of Bone with Pulmonary Metastases:Treatment by Combination of Chemotherapy and Whole-Lung Radiotherapy. Case Report

Year 2007, Volume: 12 Issue: 4, 306 - 310, 01.08.2007

Cenk Özkan Aydıner Kalacı Serdar Özbarlas

Abstract

Giant cell tumors can exhibit malignant behaviour and metastasize in 1% to 9% of patients. Patients with lung metastases from giant cell tumors are treated by surgical resection with very good survival rates. Chemotherapy and radiotherapy have been reserved primarily for patients with unresectable and symptomatic lung metastases. From the authors' literature search, no patients were treated with whole-lung radiotherapy and combined chemotherapy without surgical resection. In this report, we present 8.5 years follow up of a patient with giant cell tumor of bone with pulmonary metastases treated by combination of chemotherapy with whole-lung radiotherapy without surgical resection for lung metastases. ©2007, Fırat University, Medical Faculty

Keywords

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Akciğer Metastazlı, Kemiğin Dev Hücreli Tümörü: Kemoterapi ve Tüm Akciğer Radyoterapi Tedavi Kombinasyonu. Olgu Sunumu

Abstract

Dev hücreli tümör %1'den %9'a değişen oranlarda malign davranış ve metastaz sergileyebilir. Dev hücreli tümör akciğer metastazlı hastalar cerrahi reseksiyonla çok yüksek oranda tedavi edilir. Kemoterapi ve ışın tedavisi öncelikle semptomatik akciğer metastazlı ve cerrahi olarak rezeke edilemeyen hastalara saklanmalıdır. Cerrahi rezeksiyon yapılmaksızın tüm akciğer ışın tedavisiyle birlikte kemoterapiyle tedavi edilen hastaya literatürde rastlamadık. Bu olgu sunumunda, akciğer metastazı için cerrahi eksizyon yapılmaksızın kemoterapiyle birlikte tüm akciğere ışın tedavisi uygulanan dev hücreli tümör akciğer metastazlı hastanın 8.5 yıllık takibini sunduk. ©2007, Fırat Üniversitesi, Tıp Fakültesi

Keywords

Dev hücreli tümör, Işın tedavisi, Kemoterapi, Tümör metastazı

References

• Feigenberg SJ, Marcus RB Jr, Zlotecki RA, Scarborough MT, Enneking WF. Whole-lung radiotherapy for giant cell tumors of bone with pulmonary metastases. Clin Orthop 2002; 401: 202- 208.
• Sung HW, Kuo DP, Shu WP, Chai YB, Liu CC, Li SM. Giant- cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg Am 1982; 64: 755-761.
• Jewell JH, Bush LF. Benign giant cell tumor of bone with a solitary pulmonary metastasis. J Bone Joint Surg Am 1964; 46: 848-852.
• Kay RM, Eckardt JJ, Seeger LL, Mirra JM, Hak DJ. Pulmonary metastasis of benign giant cell tumor of bone. Six histologically confirmed cases, including one of spontaneous regression. Clin Orthop 1994; 302: 219-230.
• Tubbs WS, Brown LR, Beabout JW, Rock MG, Unni KK. Benign giant-cell tumor of bone with pulmonary metastases: clinical findings and radiologic appearance of metastases in 13 cases. AJR Am J Roentgenol 1992; 158: 331-334.
• Rock MG, Pritchard DJ, Unni KK. Metastases from histologically benign giant-cell tumor of bone. J Bone Joint Surg Am 1984; 66: 269-274.
• Osaka S, Toriyama M, Taira K, Sano S, Saotome K. Analysis of giant cell tumor of bone with pulmonary metastases. Clin Orthop 1997; 335: 253-261.
• Siebenrock KA, Unni KK, Rock MG. Giant-cell tumour of bone metastasising to the lungs. A long-term follow-up. J Bone Joint Surg Br 1998; 80: 43-47.
• Goldenberg RR, Campbell CJ, Bonfiglio M. Giant-cell tumor of bone. An analysis of two hundred and eighteen cases. J Bone Joint Surg Am 1970; 52: 619-664.
• Stargardter FL, Cooperman LR. Giant-cell tumor of sacrum with multiple pulmonary metastases and long term survival. Br J Radiol 1971; 44: 976-979.
• Bertoni F, Present D, Enneking WF. Giant-cell tumor of bone with pulmonary metastases. J Bone Joint Surg Am 1985; 67: 890- 900.
• Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am 1987; 69: 106-114.
• Maloney WJ, Vaughan LM, Jones HH, Ross J, Nagel DA. Benign metastasizing giant-cell tumor of bone. Report of three cases and review of the literature. Clin Orthop 1989; 243: 208- 215.
• Cheng JC, Johnston JO. Giant cell tumor of bone. Prognosis and treatment of pulmonary metastases. Clin Orthop 1997; 338: 205- 214.
• Enneking WF. Lesions of uncertain origin originating in bone. In: Enneking WF (ed) Musculoskeletal Tumor Surgery. Vol 2. New York: Churchill Livingstone, 1983: 1435-1467.
• Bertoni F, Present D, Sudanese A, Baldini N, Bacchini P, Campanacci M. Giant-cell tumor of bone with pulmonary metastases. Six case reports and a review of the literature. Clin Orthop 1988; 237: 275-285.
• Jaffe HL. Giant-cell tumor of bone. Its pathologic delimitation and inherent clinical implication. Ann R Coll Surg 1953; 13: 343- 355 (Abstract).
• Kabul Tarihi: 21.02.2007