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The Levels of Vitamine A in Laryngeal Carcinoma

Year 2005, Volume: 10 Issue: 2, 45 - 47, 01.04.2005

Abstract

Objectives: To investigate the level of vitamin A which cause the inhibition of the cell proliferation and induction of the cell differantation in the carcinoma of the larynx. Materials and Methods: This study included the 29 patients who had the carcinoma of the larynx. Mean age of the patients was 58,7±7,4. All of the patients were male and none of them were using vitamins. Levels of Vitamin A were evaluated in all patients. Findings were compared with control group that included 32 subjects. Results: Asignificant decrease was seen in the levels of vitamin A in patients with carcinoma of the larynx when compared with the levels of vitamin A in control group(p

References

  • Goodman DS: Vitamin A and Retinoids in Health and Disease. N Engl J Med 1984; 310: 1023-1031.
  • Watson RR, Leonard TK:Selenium and Vitamins A, E and C:Nutritients with Cancer revention Properties. Am Diet Assoc J 1986; 86: 505-510.
  • Sporn MB, Robents AB: The role of retinoids in differantation and carcinogenesis. Cancer Res 1983; 43: 3034-3040,.
  • Lippman SM, Kessler JF, Meyskens FL: Retinoids as preventive and therapeutic anticancer agents. Cancer tratment reports 1987; 71: 391-405.
  • Strickland,S. and Mahdavi, V., The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell, 1978; 15: 393- 403.
  • Lotan R., Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cell. Biochemica Biophysica Acta, 1980,605,33-91.
  • Ingeborg Klaassen, Boudewijn J.M. Braakhuis. Anticancer activity and mechanism of action of retinoids in oral and pharyngeal cancer. Oral Oncology 2002; 38: 532-542.
  • Gudas LJ, Sporn MB, Roberts AB. Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids. Biology, chemistry and medicine. 2nd ed. New York: 1994: 443-520.
  • Menkes MS, Comstock GW, Vuilleumier JP, Helsing JK, Rider AA, Brookmeyer R: Serum beta carotene, vitamins A and E, selenium and the risk of lung cancer. N. Engl J Med 1986; 315: 1250-1254.
  • Wynder EL, Bross IJ (1961) A Study of etiological factors in cancer of the esophagus. Cancer 14: 389-398.
  • Mayne ST, Risch HA, Dubrow R, et al (2001) Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 10: 1055-1062.
  • Richard M. Niles PhD. Recent advances in the use of Vitamin A (Retinoids) in the prevention and treatment of cancer. Nutrition 2000, 16: 1084-1090.
  • Wald N, Idle M, Boreham J, Bailey A. Low serum-vitamin A and subsequent risk of cancer. Preliminary results of a prospective study. Lancet 1980; II: 813-815.
  • Zheng W, Blot WJ, Diamond EL, et al. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Research 1993; 53: 795-798.
  • Fontham ET. Protective dietary factors and lung cancer. Int J Epidemiol 1990; 19: S32-0S42.
  • Klaassen I, Brakenhoff RH, Smeets SJ, Snow GB, Braakhuis BJ. Enhanced turnover of all-trans-retinoic acid and increased formation of polar metabolites in head and neck squamous cell carcinoma lines compared with normal oral keratinocytes. Clin Cancer Res 2001; 7: 1017-1025.
  • Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, et al. 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 1986; 315: 1501-1505.
  • Schepman KP, van der Meij EH, Smeele LE, van der Waal I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol 1998; 34: 270- 275.
  • Braakhuis BJM, TaborMPT, Leemans CR, Van der Waal I, Snow, GB, Brakenhoff Rh. Second primary tumors and field cancerization in oral and oropharyngeal cancer:molecular techniques provide new insights and definitions. Head Neck, 2001.
  • Haughey, B.H., Gates, G.A., Arfken, C.L. and Harvey,J. Meta- analysis of second malignant tumors in head and neck cancer: The case for an endoscopic screening protocol. Annals of Otology, Rhinology and Laryngology, 1992; 101: 105-112
  • Hong, W.K., Lippman, S.M, Itri, L.M., et al. Prevention of second primary tumors with isotrenoin in squamous-cell carcinoma of the head and neck. New England Journal of Medicine, 1990; 323: 795-801
  • Shi-Yong Sun, Reuben Lotan. Retinoids and their receptors in cancer development and chemoprevention. Critical Reviews in Oncology Hematology 41 (2002): 41-55.
  • Benner SE, Pajak TF, Lippman SM, Earley C, Hong WK. Prevention of second primary tumors with isotretinoin in patients with squamous cell carcinoma of the head and neck: long-term follow-up. J Natl Cancer Inst. 1994; 86: 140-141.
  • Hong WK, Itri LM. Retinoids and human and cancer. In: Sporn MB, Roberts SB, Goodman DS, editors. The retinoids. New York: Raven Press, 1994: 597-658.
  • Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996; 10: 940-945.
  • Drozdz M, Gierek T, Jendryczko Apiekarska J, Pilch J, Polanska D: Zinc, Vitamins A and E, and Retinol-Binding Protein in Sera or Patients with Cancer of the Larynx. Neoplasm 36; 1989: 357- 362.
  • Picker H, Bichler E: Nutritional and Immunological Investigations in Head and Neck Cancer Patients Before and After Therapy. Arch Otolaryngol 1985; 242: 149-153.
  • Kabul Tarihi:30.03.2005

Larenks Epidermoid Kanserinde Vitamin A Düzeyi

Year 2005, Volume: 10 Issue: 2, 45 - 47, 01.04.2005

Abstract

Amaç: Hücre proliferasyonunun inhibisyonu ve hücresel diferansiyasyon indüksiyonuna neden olan A Vitamini'nin larenks karsinomunda düzeyini araştırmak. Gereç ve Yöntem: Çalışmaya 29 larenks epidermoid karsinomlu hasta alındı. Yaş ortalaması 58,7±7,4 idi. Hastaların tümü erkek ve daha önceden vitamin kullanım hikayesi yoktu. Tüm hastaların A vitamini düzeyleri ölçüldü ve 32 kişilik kontrol grubu ile karşılaştırıldı. Bulgular: Hasta grubunun Vitamin A düzeyleri kontrol grubu ile karşılaştırıldığında hasta grubun Vitamin A düzeylerinde anlamlı düzeyde düşük olduğu (p

References

  • Goodman DS: Vitamin A and Retinoids in Health and Disease. N Engl J Med 1984; 310: 1023-1031.
  • Watson RR, Leonard TK:Selenium and Vitamins A, E and C:Nutritients with Cancer revention Properties. Am Diet Assoc J 1986; 86: 505-510.
  • Sporn MB, Robents AB: The role of retinoids in differantation and carcinogenesis. Cancer Res 1983; 43: 3034-3040,.
  • Lippman SM, Kessler JF, Meyskens FL: Retinoids as preventive and therapeutic anticancer agents. Cancer tratment reports 1987; 71: 391-405.
  • Strickland,S. and Mahdavi, V., The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell, 1978; 15: 393- 403.
  • Lotan R., Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cell. Biochemica Biophysica Acta, 1980,605,33-91.
  • Ingeborg Klaassen, Boudewijn J.M. Braakhuis. Anticancer activity and mechanism of action of retinoids in oral and pharyngeal cancer. Oral Oncology 2002; 38: 532-542.
  • Gudas LJ, Sporn MB, Roberts AB. Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids. Biology, chemistry and medicine. 2nd ed. New York: 1994: 443-520.
  • Menkes MS, Comstock GW, Vuilleumier JP, Helsing JK, Rider AA, Brookmeyer R: Serum beta carotene, vitamins A and E, selenium and the risk of lung cancer. N. Engl J Med 1986; 315: 1250-1254.
  • Wynder EL, Bross IJ (1961) A Study of etiological factors in cancer of the esophagus. Cancer 14: 389-398.
  • Mayne ST, Risch HA, Dubrow R, et al (2001) Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 10: 1055-1062.
  • Richard M. Niles PhD. Recent advances in the use of Vitamin A (Retinoids) in the prevention and treatment of cancer. Nutrition 2000, 16: 1084-1090.
  • Wald N, Idle M, Boreham J, Bailey A. Low serum-vitamin A and subsequent risk of cancer. Preliminary results of a prospective study. Lancet 1980; II: 813-815.
  • Zheng W, Blot WJ, Diamond EL, et al. Serum micronutrients and the subsequent risk of oral and pharyngeal cancer. Cancer Research 1993; 53: 795-798.
  • Fontham ET. Protective dietary factors and lung cancer. Int J Epidemiol 1990; 19: S32-0S42.
  • Klaassen I, Brakenhoff RH, Smeets SJ, Snow GB, Braakhuis BJ. Enhanced turnover of all-trans-retinoic acid and increased formation of polar metabolites in head and neck squamous cell carcinoma lines compared with normal oral keratinocytes. Clin Cancer Res 2001; 7: 1017-1025.
  • Hong WK, Endicott J, Itri LM, Doos W, Batsakis JG, Bell R, et al. 13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med 1986; 315: 1501-1505.
  • Schepman KP, van der Meij EH, Smeele LE, van der Waal I. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol 1998; 34: 270- 275.
  • Braakhuis BJM, TaborMPT, Leemans CR, Van der Waal I, Snow, GB, Brakenhoff Rh. Second primary tumors and field cancerization in oral and oropharyngeal cancer:molecular techniques provide new insights and definitions. Head Neck, 2001.
  • Haughey, B.H., Gates, G.A., Arfken, C.L. and Harvey,J. Meta- analysis of second malignant tumors in head and neck cancer: The case for an endoscopic screening protocol. Annals of Otology, Rhinology and Laryngology, 1992; 101: 105-112
  • Hong, W.K., Lippman, S.M, Itri, L.M., et al. Prevention of second primary tumors with isotrenoin in squamous-cell carcinoma of the head and neck. New England Journal of Medicine, 1990; 323: 795-801
  • Shi-Yong Sun, Reuben Lotan. Retinoids and their receptors in cancer development and chemoprevention. Critical Reviews in Oncology Hematology 41 (2002): 41-55.
  • Benner SE, Pajak TF, Lippman SM, Earley C, Hong WK. Prevention of second primary tumors with isotretinoin in patients with squamous cell carcinoma of the head and neck: long-term follow-up. J Natl Cancer Inst. 1994; 86: 140-141.
  • Hong WK, Itri LM. Retinoids and human and cancer. In: Sporn MB, Roberts SB, Goodman DS, editors. The retinoids. New York: Raven Press, 1994: 597-658.
  • Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996; 10: 940-945.
  • Drozdz M, Gierek T, Jendryczko Apiekarska J, Pilch J, Polanska D: Zinc, Vitamins A and E, and Retinol-Binding Protein in Sera or Patients with Cancer of the Larynx. Neoplasm 36; 1989: 357- 362.
  • Picker H, Bichler E: Nutritional and Immunological Investigations in Head and Neck Cancer Patients Before and After Therapy. Arch Otolaryngol 1985; 242: 149-153.
  • Kabul Tarihi:30.03.2005
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Üzeyir Gök This is me

Ayca Tazegül This is me

Publication Date April 1, 2005
Published in Issue Year 2005 Volume: 10 Issue: 2

Cite

APA Gök, Ü., & Tazegül, A. (2005). Larenks Epidermoid Kanserinde Vitamin A Düzeyi. Fırat Tıp Dergisi, 10(2), 45-47.
AMA Gök Ü, Tazegül A. Larenks Epidermoid Kanserinde Vitamin A Düzeyi. Fırat Tıp Dergisi. April 2005;10(2):45-47.
Chicago Gök, Üzeyir, and Ayca Tazegül. “Larenks Epidermoid Kanserinde Vitamin A Düzeyi”. Fırat Tıp Dergisi 10, no. 2 (April 2005): 45-47.
EndNote Gök Ü, Tazegül A (April 1, 2005) Larenks Epidermoid Kanserinde Vitamin A Düzeyi. Fırat Tıp Dergisi 10 2 45–47.
IEEE Ü. Gök and A. Tazegül, “Larenks Epidermoid Kanserinde Vitamin A Düzeyi”, Fırat Tıp Dergisi, vol. 10, no. 2, pp. 45–47, 2005.
ISNAD Gök, Üzeyir - Tazegül, Ayca. “Larenks Epidermoid Kanserinde Vitamin A Düzeyi”. Fırat Tıp Dergisi 10/2 (April 2005), 45-47.
JAMA Gök Ü, Tazegül A. Larenks Epidermoid Kanserinde Vitamin A Düzeyi. Fırat Tıp Dergisi. 2005;10:45–47.
MLA Gök, Üzeyir and Ayca Tazegül. “Larenks Epidermoid Kanserinde Vitamin A Düzeyi”. Fırat Tıp Dergisi, vol. 10, no. 2, 2005, pp. 45-47.
Vancouver Gök Ü, Tazegül A. Larenks Epidermoid Kanserinde Vitamin A Düzeyi. Fırat Tıp Dergisi. 2005;10(2):45-7.