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The Value of Color Duplex Sonography in the Discrimination of Benign and Malign Breast Masses

Year 2005, Volume: 10 Issue: 2, 68 - 71, 01.04.2005

Abstract

Objectives: In our study, we aimed to investigate the value of color duplex sonography (CDUS) in the discrimination of benign and malign breast masses. Materials and Methods: A total of 53 patients aged 26-69 years who had breast masses in their mammography and/or ultrasound, were enrolled in the study. The presence of vascularity within the mass, localization of the vascular structures and the type of flow were determined with CDUS. In the patients who had flow, resistive index (RI) and pulsatility index (PI) values were measured. Histopathologic results of the masses were obtained with biopsies or operation results. Results: In 28 of 31 patients (90.3%) who were suggested to have malign breast masses in their mammography and/or ultrasonography and subsequently supported histopathologically, vascularity was provided from the mass in the CDUS. The range of RI and PI values varied between 0.57 and 1.00 (mean value of RI: 0.74) and between 0.90 and 3.17 (mean value of PI: 1.48) respectively. In 11 of 22 (50%) breast masses which were found to be benign histologically, flow was present within these masses. RI values were between 0.50 and 0.86 (mean value of RI: 0.65), PI values were between 0.67 and 2.43 (mean value of PI: 1.10). Conclusion: Arterial flow within the mass was detected in more patients with malign breast masses compared to the patients with benign masses. Significant difference was found between RI and PI values of the two groups. RI and PI values were increased in the malign group. ©2005, Fırat Üniversitesi, Tıp Fakültesi

References

  • Cosgrove D, Bamber JC, Davey JB, McKinna JA. Color Doppler signals from breast tumors. Work in progress. Radiology 1990; 176: 175-180.
  • Weidner N, Semple JP, Welch WR, Folkman J. Tumor angioneogenesis and metastases: correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8.
  • Dickson RB, Lippman ME. Molecular determinants of growth, angioneogenesis and metastases in breast cancer. Semin Oncol 1993; 19: 286-298.
  • Folkman J, Klagsburn M. Angiogenetic factors. Science 1987; 235: 442-447.
  • Bergonzi M, Calliada F, Passamonti C. et. al. II contribut del colour Doppler nella valutazione ecografica dei noduli mammari. Radiol Med 1990,79:178-81.
  • Taylor KJ, Ramos I, Carter D, Morse SS, Snower D, Fortune K. Correlation of Doppler US tumor signals with neovascular morphologic features. Radiology 1998; 166: 54-62.
  • Engin G. Meme lezyonlarının tanısında ultrasonografi ve renkli Doppler ultrasonografi. Türk Radyoloji Dergisi 1998; 33: 103- 112.
  • Dock W, Grabenwoger F, Metz V, Eibenberger K, Farres MT. Tumor vascularization: assessment with duplex sonography. Radiology 1991; 181: 241-244.
  • Wilkens TH, Burke BJ, Cancelada DA, Jatoi I. Evaluation of palpable breast masses with color Doppler sonography and gray scale imaging. J Ultrasound Med 1998; 17: 109-115.
  • Schelling M, Gnirs J, Braun M, et al. Optimized differential diagnosis of breast lesions by combined B-mode and color Doppler sonography. Ultrasound Obstet Gynecol 1997; 10: 48- 53.
  • Cole-Beuglet C, Soriano RZ, Kurtz AB, Goldberg BB. Ultrasound analysis of 104 primary breast carcinomas classified according to histopathologic type. Radiology 1983; 147: 191-6.
  • Britton PD, Coulden RA. The use of duplex Doppler ultrasound in the diagnosis of breast cancer. Clin Radiol 1990; 42: 399-401.
  • Dixon JM, Walsh J, Peterson D, Chetty U. Color Doppler Ultrasonography studies of benign and malignant breast lesions. Br J Surg 1992; 79: 259-260.
  • Cosgrove DO, Kedar RP, Bamber JC et al. Breast diseases: color Doppler US in differantial diagnosis. Radiology 1993; 189: 99- 104.
  • Guiseppetti GM, Baldassarre S, Marconi E. Color doppler sonography. Eur J Radiol 1998; 27: 254-258.
  • Konishi Y, Hamada M, Shimada K et al. Doppler spectral analysis of the intratumoral waveform in breast disease. Imaging 1993; 60 (suppl 2):18.
  • Sohn C, Stolz W, Grischke EM, Wallwiener D, Bastert G, von Fournier D. Doppler ultrasound study of breast tumors using color Doppler ultrasound, duplex ultrasound and the CW Doppler ultrasound. Zentralbl Gynakol 1992, 114: 249-253.
  • Peters-Engl C, MedlM, Leodolter S. The use of color-coded and spectral Doppler ultrasound in the differantion of benign and malign breast lesions. Br J Cancer 1995; 71: 137-139.
  • Chao TC, Lo YF, Chen SC, Chen MF. Color doppler ultrasound in benign and malignant breast tumors. Breast Cancer Res Treat 1999; 57: 193-199 .
  • Madjar H, Sauerbrei W, Prompeler HJ et al. Color doppler and duplex flow analysis for classification of breast lesions. Gynecol Oncol 1997; 64: 392-403.
  • Youssefzadeh S, Eibenberger K, Helbich T, Jakesz R, Wolf G. Use of resistive index for diagnosis of breast tumors. Clin Radiol 1996; 51: 418-420.
  • Algül A, Balcı P, Seçil M, Canda T. Meme kitlelerinde kontrastlı power Doppler ve renkli Doppler US: tanısal etkinlikleri ve ayırıcı tanıya katkıları. Tani Girisim Radyol 2003; 9: 199-206.
  • Kabul Tarihi: 07.04.2005

Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri

Year 2005, Volume: 10 Issue: 2, 68 - 71, 01.04.2005

Abstract

Amaç: Çalışmamızda, renkli dupleks ultrasonografinin (RDUS) benign ve malign meme kitlelerinin ayırımındaki yerini incelemeyi amaçladık. Gereç ve Yöntem: Mammografilerinde ve/veya ultrasonografilerinde meme kitlesi saptanan, yaşları 26 ile 69 arasında değişen toplam 53 olgu çalışmaya alındı. RDUS ile kitle içerisindeki vaskülarite varlığı, vasküler yapıların lokalizasyonu ve akım türü belirlendi. Arteriyal akım saptanan olgularda, rezistif indeks (RI) ve pulsatilite indeks (PI) değerleri ölçüldü. Kitlelerin histopatolojik sonuçları aspirasyon-eksizyonel biyopsilerle veya operasyon sonuçlarıyla elde edildi. Bulgular: Mammografi ve/veya ultrasonografi bulgularına göre malign meme kitlesi olduğu düşünülen ve histopatolojisi ile desteklenen 31 olgunun 28'inde (%90.3) RDUS'da kitleden vasküler akım alındı. RI değerleri 0.57 ile 1.00 arasındaydı (ortalama RI: 0.74). PI değerleri 0.90 ile 3.17 arasındaydı (ortalama PI: 1.48). Histopatolojisi benign olarak tespit edilen 22 meme kitlesinin 11'inde (% 50) akım mevcuttu. RI değerleri 0.50 ile 0.86 (ortalama RI: 0.65), PI değerleri 0.67 ile 2.43 (ortalama PI: 1.10 ) arasındaydı. Sonuç: Malign meme kitlelerinde benignlere göre daha yüksek oranda arteriyal akım saptandı. Her iki grup arasındaki RI ve PI değerlerinde anlamlı fark tespit edildi. RI ve PI değerleri malign grupta artmıştı. ©2005, Fırat Üniversitesi, Tıp Fakültesi

References

  • Cosgrove D, Bamber JC, Davey JB, McKinna JA. Color Doppler signals from breast tumors. Work in progress. Radiology 1990; 176: 175-180.
  • Weidner N, Semple JP, Welch WR, Folkman J. Tumor angioneogenesis and metastases: correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8.
  • Dickson RB, Lippman ME. Molecular determinants of growth, angioneogenesis and metastases in breast cancer. Semin Oncol 1993; 19: 286-298.
  • Folkman J, Klagsburn M. Angiogenetic factors. Science 1987; 235: 442-447.
  • Bergonzi M, Calliada F, Passamonti C. et. al. II contribut del colour Doppler nella valutazione ecografica dei noduli mammari. Radiol Med 1990,79:178-81.
  • Taylor KJ, Ramos I, Carter D, Morse SS, Snower D, Fortune K. Correlation of Doppler US tumor signals with neovascular morphologic features. Radiology 1998; 166: 54-62.
  • Engin G. Meme lezyonlarının tanısında ultrasonografi ve renkli Doppler ultrasonografi. Türk Radyoloji Dergisi 1998; 33: 103- 112.
  • Dock W, Grabenwoger F, Metz V, Eibenberger K, Farres MT. Tumor vascularization: assessment with duplex sonography. Radiology 1991; 181: 241-244.
  • Wilkens TH, Burke BJ, Cancelada DA, Jatoi I. Evaluation of palpable breast masses with color Doppler sonography and gray scale imaging. J Ultrasound Med 1998; 17: 109-115.
  • Schelling M, Gnirs J, Braun M, et al. Optimized differential diagnosis of breast lesions by combined B-mode and color Doppler sonography. Ultrasound Obstet Gynecol 1997; 10: 48- 53.
  • Cole-Beuglet C, Soriano RZ, Kurtz AB, Goldberg BB. Ultrasound analysis of 104 primary breast carcinomas classified according to histopathologic type. Radiology 1983; 147: 191-6.
  • Britton PD, Coulden RA. The use of duplex Doppler ultrasound in the diagnosis of breast cancer. Clin Radiol 1990; 42: 399-401.
  • Dixon JM, Walsh J, Peterson D, Chetty U. Color Doppler Ultrasonography studies of benign and malignant breast lesions. Br J Surg 1992; 79: 259-260.
  • Cosgrove DO, Kedar RP, Bamber JC et al. Breast diseases: color Doppler US in differantial diagnosis. Radiology 1993; 189: 99- 104.
  • Guiseppetti GM, Baldassarre S, Marconi E. Color doppler sonography. Eur J Radiol 1998; 27: 254-258.
  • Konishi Y, Hamada M, Shimada K et al. Doppler spectral analysis of the intratumoral waveform in breast disease. Imaging 1993; 60 (suppl 2):18.
  • Sohn C, Stolz W, Grischke EM, Wallwiener D, Bastert G, von Fournier D. Doppler ultrasound study of breast tumors using color Doppler ultrasound, duplex ultrasound and the CW Doppler ultrasound. Zentralbl Gynakol 1992, 114: 249-253.
  • Peters-Engl C, MedlM, Leodolter S. The use of color-coded and spectral Doppler ultrasound in the differantion of benign and malign breast lesions. Br J Cancer 1995; 71: 137-139.
  • Chao TC, Lo YF, Chen SC, Chen MF. Color doppler ultrasound in benign and malignant breast tumors. Breast Cancer Res Treat 1999; 57: 193-199 .
  • Madjar H, Sauerbrei W, Prompeler HJ et al. Color doppler and duplex flow analysis for classification of breast lesions. Gynecol Oncol 1997; 64: 392-403.
  • Youssefzadeh S, Eibenberger K, Helbich T, Jakesz R, Wolf G. Use of resistive index for diagnosis of breast tumors. Clin Radiol 1996; 51: 418-420.
  • Algül A, Balcı P, Seçil M, Canda T. Meme kitlelerinde kontrastlı power Doppler ve renkli Doppler US: tanısal etkinlikleri ve ayırıcı tanıya katkıları. Tani Girisim Radyol 2003; 9: 199-206.
  • Kabul Tarihi: 07.04.2005
There are 23 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ayşe Murat This is me

Anıl Arslan This is me

Erkin Oğur This is me

Publication Date April 1, 2005
Published in Issue Year 2005 Volume: 10 Issue: 2

Cite

APA Murat, A., Arslan, A., & Oğur, E. (2005). Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri. Fırat Tıp Dergisi, 10(2), 68-71.
AMA Murat A, Arslan A, Oğur E. Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri. Fırat Tıp Dergisi. April 2005;10(2):68-71.
Chicago Murat, Ayşe, Anıl Arslan, and Erkin Oğur. “Benign Ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri”. Fırat Tıp Dergisi 10, no. 2 (April 2005): 68-71.
EndNote Murat A, Arslan A, Oğur E (April 1, 2005) Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri. Fırat Tıp Dergisi 10 2 68–71.
IEEE A. Murat, A. Arslan, and E. Oğur, “Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri”, Fırat Tıp Dergisi, vol. 10, no. 2, pp. 68–71, 2005.
ISNAD Murat, Ayşe et al. “Benign Ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri”. Fırat Tıp Dergisi 10/2 (April 2005), 68-71.
JAMA Murat A, Arslan A, Oğur E. Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri. Fırat Tıp Dergisi. 2005;10:68–71.
MLA Murat, Ayşe et al. “Benign Ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri”. Fırat Tıp Dergisi, vol. 10, no. 2, 2005, pp. 68-71.
Vancouver Murat A, Arslan A, Oğur E. Benign ve Malign Meme Kitlelerinin Ayırımında Renkli Dupleks Ultrasonografinin Yeri. Fırat Tıp Dergisi. 2005;10(2):68-71.