Identification of potential hub genes as biomarkers for breast, ovarian, and endometrial cancers

Year 2024, , 74 - 82, 30.04.2024

Sema Atasever

https://doi.org/10.51753/flsrt.1405816

Abstract

Breast cancer (BC) and gynecological cancers have emerged as significant threats to women’s health and are known to be among the primary causes of cancer-related fatalities in women. Innovative treatments and early detection may significantly cut mortality rates for these diseases. In this study, potential hub genes were thoroughly evaluated in the contexts of BC, ovarian cancer (OC), and endometrial cancer (EC). Initially, a total of 374 overlapping differentially expressed genes (DEGs) were identified within the microarray datasets. The STRING database and Cytoscape software analyzed protein-protein interaction (PPI) network structure, whereas FunRich found hub genes. The five hub genes that were ultimately discovered are PTEN, SMAD2, FASN, CYCS, and KRAS. As a result, these genes may serve as potential biomarkers for the aforementioned diseases. Importantly, this study offers valuable insights into all three diseases based on recent molecular advancements. However, further investigation is required to precisely measure these biomarkers’ effectiveness.

Keywords

Breast cancer, DEGs, endometrial cancer, enriched pathway, hub gene, ovarian cancer, potential biomarker

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