Skin microbiome manipulation via activated charcoal strips for relieving erythema among dogs with cutaneous disease phenotypes of different origins

Abstract

Several bacteria could selectively use substrates among a combination of different carbon sources. Activated carbons exhibit a position for essential medicines and are involved in battling gastrointestinal and dermatological issues by removing toxins from the skin. Herein, in this research, we hypothesized that activated carbon nose pore strips could have helped diminish erythema scores, which is a concern for owners at initial dermatological referral. For this purpose, 116 pure or cross-bred owned dogs, from several different breeds, age and of both sexes, were deemed available for enrollment in 3 different groups. For a tentative diagnosis of atopic dermatitis (n=57, group I), cutaneous adverse food reaction (n=40, group II) and demodicosis (n=19, group III); epidermal corneometric analytes (skin pH and hydration), in vitro Ig E detection, dermatoscopy, bioresonance, breath nitric oxide test (low grade systemic inflammation), skin cytology along with visual analogue scale erythema severity score were deemed available. Erythema scoring was graded as 0 to 3. Skin microbiome manipulation by use of Activated charcoal (A-ch) nose strips was based on previously defined methodology by the same researcher group. A-ch Nose Pore Strips were placed onto the lesional skin, moistened, for at least 10 minutes. This allowed probable withdrawal of pathogens (removal), which were then A-ch strips removed. Day 10 measurements for the Visual analogue scale erythema severity score (VAS-ESS) revealed a difference between group II and others (p<0.001). Moreover, intra-group comparison exhibited significant decreases (p<0.001) were validated for groups 1, 2, and 3 between day 0 and 10 values. Mean VAS-ESS were 2.88 vs. 1.05, 2.62 vs. 1.20, and 2.58 vs. 0.95, before and after treatment for groups I, II, and III, respectively.

Keywords

• Activated carbon
• atopic dermatitis
• canine dermatology
• demodicosis
• erythema score
• microbiome modulation

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