Tamoksifen tedavisi gören meme kanserli Irak’lı hastalarda serum adenozin deaminaz aktivitesi

Abstract

Breast cancer (BC) is a type of cancer originating from breast tissue, Tamoxifen is the usual endocrine therapy for breast cancer in premenopausal women, and also in post-menopausal women. Adenosine deaminase (ADA) is an enzyme involved in purine metabolism, and also increased in most cancers. It is aimed to assess the status of ADA in women with BC on tamoxifen therapy in this study. The present study is a cross-sectional study (2010/2011) done at Al-Kadhumia Teaching Hospital. The procedure includes measurement of ADA in sera of women with BC who were estrogen positive (whether on tamoxifen treatment or not). This measurement was done using ELISA Kit for Adenosine Deaminase (ADA) E91390Hu. A total of 160 patients with BC were involved in this study, they were classified as newly diagnosed premenopausal women with BC G1: (n=40); newly diagnosed postmenopausal women with BC G2: (n=40); Premenopausal women with BC on tamoxifen therapy G3: (n=40); Postmenopausal women with BC on tamoxifen therapy G4: (n=40). A matching group of eighty apparently healthy women who were included as controls (n=80), who were classified as Premenopausal women G5: (n=40); Postmenopausal women with G6: (n=40). Serum ADA was significantly reduced in women with BC receiving tamoxifen therapy when compared with newly diagnosed patients with BC (p < 0.001) and even with controls (p < 0.05). In conclusion, patients with BC have high level of serum ADA compared with controls; however, the level of ADA was significantly reduced upon tamoxifen treatment. The above results were supported by the significant alteration in levels of s. ADA indicating high rate of malignant cell-turn-over resulting in high rate of purine catabolism which is limited by tamoxifine adminstration.

Keywords

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Serum adenosine deaminase activity in Iraqi patients with breast cancer on tamoxifen therapy

Abstract

Meme kanseri meme dokusundan kaynaklanan bir kanser tipidir. Tamoksifen hem postmenapozal hem de premenapozal kadınlardaki meme kanserleri için kullanılan yaygın bir endokrin terapisidir. Adenozin deaminaz(ADA) purin metabolizmasında yer alır ve aynı zamanda çoğu kanserde artmıştır. Bu çalışmada tamoksifen terapisi alan meme kanserli hastalardaki ADA durumunu değerlendirilmesi amaçlanmıştır. Mevcut çalışma kesitsel bir çalışma olup 2010-2011 yılları arasında Al-Kadhuma Eğitim Hastanesi’nde yapılmıştır. Bu prosedür östrojen pozitif (tamoksifen tedavisi alan veya almayan) olan meme kanserli hastaların serumlarındaki ADA ölçümünü içermektedir. Bu ölçüm ELISA Kit for Adenosine Deaminase (ADA) E91390Hu kullanılarak yapılmıştır. Toplam 160 hasta çalışmaya dahil edilmiş olup bunlar yeni teşhis edilmiş premenopozal kadınlar BC G1: (n=40); yeni teşhis edilmiş postmenopozal kadınlar BC G2: (n=40); tamoksifen terapisindeki meme kanserli premenopozal kadınlar G3: (n=40); tamoksifen terapisindeki meme kanserli postmenopozal kadınlar G4: (n=40) olarak sınıflandırılmışlardır. Karşılaştırma grubu olarak 80 sağlıklı kadın, kontrol grubu olarak (n=80) çalışmaya dahil edilmiş olup premenopozal kadınlar G5: (n=40); postmenopozal kadınlar G6: (n=40) olarak sınıflandırılmışlardır. Yeni teşhis edilmiş meme kanserli kadınlarla karşılaştırıldığında, serum ADA seviyesi tamoksifen alan hastalarda önemli ölçüde düşmüştü (p

Keywords

• Adenozin deaminaz, meme kanseri, tamoksifen

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