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Sigara bırakmanın plazma leptin düzeylerine etkisi

Year 2009, Volume: 15 Issue: 2, 1 - 4, 01.03.2009

Abstract

Cessation of smoking often induces hyperphagia and weight gain associated with decreased energy expenditure. Plasma leptin levels and adipose tissue mRNA correlate with mass of adipose tissue, and represent important signals for registration of total body energy status. In this study 19 smokers (13 male, 6 female) referring to the smoking cessation clinic were randomly assigned to control group (n:6), nicotine patch group (n:6), nicotine patch+fluoxetine group (n:7). Plasma leptin levels and, body mass indices (BMI) were determined before and 3, 6 weeks after cessation of smoking. A significant increase in BMI (p: 0,01) and in plasma leptin (p: 0.02) were observed in the 3rd and 6th weeks compared to basal levels. The univariate analysis of variance which explained 66.6% variance (p: 0.007) in body weight between 0 and 3 weeks, has indicated nicotine patch+ fluoxetine therapy, the difference in leptin levels, and difference in exhaled carbon monoxide levels as the significant contributors. The difference in body weight, study groups, and age at time of starting smoking were the significant contributors to 55.4% variance (p: 0.027) in leptin levels between 0 and 3 weeks. Plasma leptin increased together with body weight and nicotine patch+fluoxetine theraphy vs. controls. Plasma leptin concentrations have increased after cessation of cigarette smoking in vivo. Fluoxetine has an enhancing effect on leptin alongside inhibiting weight gain. We conclude that fluoxetine treatment might independently increase leptin levels.

References

  • 1. Klein LC, Corwin EJ, Ceballos RM. Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence. Addict Behav. 2004;29:921-927
  • 2. Levine MD, Perkins KA, Marcus MD. The characteristics of women smokers concerned about post cessation weight gain. Addict Behav. 2001;26:749-756
  • 3. Williamson DF, Madans J, Anda RF, Kleinman JC, Giovino GA, Byers T. Smoking cessation and severity of weight gain in a national cohort. N Eng J Med
  • 1991;324:739-745
  • 4. Klesges RC, Klesges LM. The relationship between body mass and cigarette smoking using a biochemical index of smoking exposure. Int J Obesity. 1993;17:585-591
  • 5. Hodge AM, Westerman RA, de Courten MP, Collier GR, Zimmet PZ, Alberti KGMM. Is leptin sensitivity the link between smoking cessation and weight gain? Int J Obes Relat Metab Disord. 1997;21:50-53
  • 6. Gamaro GD, Prediger ME , Lopes J, Bassani MG, Dalmaz C. Fluoxetine alters feeding behavior and leptin levels in chronically-stressed rats. Pharmacol Biochem Behav. 2008;90:312-317
  • 7.Donahue RP, Zimmet P, Bean JA, Decourten M, DeCarlo Donahue RA, Collier G, et al. Cigarette smoking, alcohol use, and physical activity in relation to serum leptin levels in a multiethnic population: The Miami Community. Health Study. Ann Epidemiol. 1999;9:108-13
  • 8. Reseland JE, Mundal HH, Hollung K, Haugen F, Zahid N, Anderssen SA, et al. Cigarette smoking may reduce plasma leptin concentration via catecholamines.Prostaglandins Leukot Essent Fatty Acids. 2005;73:43-9
  • 9. Yamada J, Sugimoto Y, Ujikawa M. The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice. Eur J Pharmacol. 1999;383:49-51
  • 10. Esel E, Özsoy S, Tutuş A, Sofuoğlu S, Kartalcı S, Bayram F, et al. Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:565-70

Plasma leptin concentrations after cessatlon of cigarette smoking

Year 2009, Volume: 15 Issue: 2, 1 - 4, 01.03.2009

Abstract

Sigara bırakılması hiperfaji ve enerji tüketiminde azalma ile ilişkili , olarak genellikle kilo artışına yol açmaktadır. Plazma leptinve doku mRNA düzeyleri yağ dokusu kütlesi ile korelasyon gösterir ve vücut toplam enerji düzeyinin habercisi olarak kabul edilir. Bu çalışmada sigara bırakma kliniğine başvuran 19 tiryaki (13 E/6 K) rastgele, kontrol grubu (n:6),'nikotin bandı (n:6) ve nikotin bandı+fluoksetin (n:7) tedavi grupları olarak siriıflaridirıldı. Plâzma leptin düzeyleri ve vücut kitle indeksi (VKİ) sigara bırakılmasından önce, bırakılmasından-3.ve , 6 hafta sonra değerlendirildi. Başlangıç değerlerine göre 3. ve 6. haftalarda leptin düzeyleri (p 0.02) ve VKİ'de (p 0.01) anlamlı bir artış saptandı. Başlangıç ve 3. hafta VKİ arasındaki farka etkili değişkenlerin %66.6'sını açıklayan (p:0.007) genel düzlemsel analize göre nikotin bandı+ fluoksetin tedavisi, leptin düzeyleri ve ekshale edilen CO düzeyleri etkili faktörler olarak saptandı.Başlangıç ve 3. hafta leptin düzeylerindeki değişkenliğin %55.4'ünü (p: 0.027) açıklayan modele göre plazma leptin düzeyleri artışı vücut ağırlığı artışı ve nikotin bandı+fluoksetin tedavisi ile ilişkili bulunmuştur. Sigara bırakılmasını takiben plazma leptin konsantrasyonları artmıştır. Fluoksetin kilo artışını engellerken, leptin düzeylerini artırıcı yönde etki göstermiştir. Sonuçlarımız Fluoksetinin leptin düzeylerine etkisinin kilo değişiminden bağımsız olduğu düşündürmektedir.

References

  • 1. Klein LC, Corwin EJ, Ceballos RM. Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence. Addict Behav. 2004;29:921-927
  • 2. Levine MD, Perkins KA, Marcus MD. The characteristics of women smokers concerned about post cessation weight gain. Addict Behav. 2001;26:749-756
  • 3. Williamson DF, Madans J, Anda RF, Kleinman JC, Giovino GA, Byers T. Smoking cessation and severity of weight gain in a national cohort. N Eng J Med
  • 1991;324:739-745
  • 4. Klesges RC, Klesges LM. The relationship between body mass and cigarette smoking using a biochemical index of smoking exposure. Int J Obesity. 1993;17:585-591
  • 5. Hodge AM, Westerman RA, de Courten MP, Collier GR, Zimmet PZ, Alberti KGMM. Is leptin sensitivity the link between smoking cessation and weight gain? Int J Obes Relat Metab Disord. 1997;21:50-53
  • 6. Gamaro GD, Prediger ME , Lopes J, Bassani MG, Dalmaz C. Fluoxetine alters feeding behavior and leptin levels in chronically-stressed rats. Pharmacol Biochem Behav. 2008;90:312-317
  • 7.Donahue RP, Zimmet P, Bean JA, Decourten M, DeCarlo Donahue RA, Collier G, et al. Cigarette smoking, alcohol use, and physical activity in relation to serum leptin levels in a multiethnic population: The Miami Community. Health Study. Ann Epidemiol. 1999;9:108-13
  • 8. Reseland JE, Mundal HH, Hollung K, Haugen F, Zahid N, Anderssen SA, et al. Cigarette smoking may reduce plasma leptin concentration via catecholamines.Prostaglandins Leukot Essent Fatty Acids. 2005;73:43-9
  • 9. Yamada J, Sugimoto Y, Ujikawa M. The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice. Eur J Pharmacol. 1999;383:49-51
  • 10. Esel E, Özsoy S, Tutuş A, Sofuoğlu S, Kartalcı S, Bayram F, et al. Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:565-70
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Binnur Erbağcı This is me

Nazan Bayram This is me

Rukiye Deveci This is me

Ayfer Topçu This is me

Publication Date March 1, 2009
Published in Issue Year 2009 Volume: 15 Issue: 2

Cite

APA Erbağcı, B., Bayram, N., Deveci, R., Topçu, A. (2009). Plasma leptin concentrations after cessatlon of cigarette smoking. Gaziantep Medical Journal, 15(2), 1-4.
AMA Erbağcı B, Bayram N, Deveci R, Topçu A. Plasma leptin concentrations after cessatlon of cigarette smoking. Gaziantep Medical Journal. March 2009;15(2):1-4.
Chicago Erbağcı, Binnur, Nazan Bayram, Rukiye Deveci, and Ayfer Topçu. “Plasma Leptin Concentrations After Cessatlon of Cigarette Smoking”. Gaziantep Medical Journal 15, no. 2 (March 2009): 1-4.
EndNote Erbağcı B, Bayram N, Deveci R, Topçu A (March 1, 2009) Plasma leptin concentrations after cessatlon of cigarette smoking. Gaziantep Medical Journal 15 2 1–4.
IEEE B. Erbağcı, N. Bayram, R. Deveci, and A. Topçu, “Plasma leptin concentrations after cessatlon of cigarette smoking”, Gaziantep Medical Journal, vol. 15, no. 2, pp. 1–4, 2009.
ISNAD Erbağcı, Binnur et al. “Plasma Leptin Concentrations After Cessatlon of Cigarette Smoking”. Gaziantep Medical Journal 15/2 (March 2009), 1-4.
JAMA Erbağcı B, Bayram N, Deveci R, Topçu A. Plasma leptin concentrations after cessatlon of cigarette smoking. Gaziantep Medical Journal. 2009;15:1–4.
MLA Erbağcı, Binnur et al. “Plasma Leptin Concentrations After Cessatlon of Cigarette Smoking”. Gaziantep Medical Journal, vol. 15, no. 2, 2009, pp. 1-4.
Vancouver Erbağcı B, Bayram N, Deveci R, Topçu A. Plasma leptin concentrations after cessatlon of cigarette smoking. Gaziantep Medical Journal. 2009;15(2):1-4.