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Prolonged jaundice in newborn babies

Year 2009, Volume: 15 Issue: 2, 49 - 55, 01.03.2009

Ercan Sivaslı

Abstract

Up to 50% of all nevvborns may develop jaundice. If serum bilirubin level is above 2 mg/dl in adults and 6 mg/dl in newborns, jaundice is visible. Prolonged neonatal jaundice is definite that high serum bilirubin (>10 mg/dl) that persists beyond 14 days of life in a matür infant or 21 days of life in a prematur infant. There may be either direct bilirubin or indirect bilirubin is high in prolonged jaundice. Prolonged jaundice can be a sign of serious underlying liver disease if direct bilirubin is high. Therefore, causes and treatments of prolonged jaundice in newborn will be reviewed in this collection.

Keywords

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References

  • l.Watchko JF, Maisels MJ. Neonatal jaundice. Semin Neonatal. 2002;7:101-103
  • 2.Wong RJ, DeSandre GH, Sibley E, Stevenson DK. Neonatal jaundice and liver disease. In: Fanaroff AA, Martin R3 (eds). Neonatal-Perinatal Medicine Disease of the Fetus and Infant. 2006;8(l):1419-1466
  • 3.Porter ML, Dennis BL. Hyperbilirubinemia in the matür newborn. Ame Fmly Phys. 2002;65:599-606
  • 4.Hannam S, McDonnell M, Rennie JM. Investigation of prolonged nenatal jaundice. Acta Paediatr. 2000;89:694-697
  • 5.Mishra S, Agarwal R, Deorari AK, Paul VK. Jaundice in the newboms. Indian J Pediatr. 2008;75:157-163
  • 6.McKiernan PJ. Neonatal cholestasis. Semin Neonatol. 2002:7; 153-157
  • 7-McKiernan PJ, Baker AJ, Kelly DA. The frequency and outcome of biliary atresia in the UK and Ireland. Lancet. 2000;355:25-29
  • 8.Newman AJ, Gross S. Hyperbilirubinemia in breast- fed infants. Pediatrics. 1963;32:995-1001
  • 9.Lawrence M. Gartner, MD. Breastfeeding and Jaundice. J Perinatol. 2001;21:25-29
  • 10.Gartner LM. Neonatal jaundice. Pediatr Rev. 1994;15:422
  • ll.Sarici SU, Saldir M. Genetic factors in neonatal hyperbilirubinemia and kernicterus. Turk J Pediatr. 2007;49:245-249
  • 12-Gourley GR, Li Z, Kreamer BL, Kosorok MR. A controlled, randomized, double-blind trial of prophylaxis against jaundice among breastfed newborns. Pediatrics. 2005;116:385-39.1
  • 13.Yiğit S, Ciliv G, Aygün C, Erdem G. Breast milk beta-glucuronidase levels in hyperbilirubinemia. Turk J Pediatr. 2001;43:118-20
  • 14.İnce Z, Çoban A, Peker I, Can G. Breast milk -glucuronidase and prolonged jaundice in the neonate. Acta Paediatr. 1995;84:237-239
  • 15.Erdem G, Öztürk R, Ciliv G, Özmert E, Tuncer M. Is beta-glucuronidase a contributory factor in early indirect hyperbilirubinemia. Acta Paediatr. 1997;86:120
  • 16.Maruo Y, Nishizawa K, Sato H, Sawa H, Shİmada M. Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene. Pediatrics 2000;106:59
  • 17.Frank 3E. Diagnosis and Management of G6PD Deficiency. Am Fam Physician. 2005;72:1277-1282
  • 18-Francisco J. Garcia and Alan L. Nager. Jaundice as an Early Diagnostic Sign of Urinary Tract Infection in Infancy. Pediatrics. 2002; 109)846-851
  • 19.Pashapour N, Nikibahksh AA, Golmohammadlou S. Urinary tract infection in matiir neonates with prolonged jaundice. Urol J. 2007;4:91-94
  • 2O.Bilgen H, Ozek E, UnverT, Biyikli N, Alpay H, Cebeci D. Urinary tract infection and hyperbilirubinemia. Turk J Pediatr. 2006;48:51-55
  • 21.Takeuchi K, Kobayashi Y, Tamaki S, Ishihara T, Maruo Y, Araki J, et al. Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects. J Gastroenterol Hepatol. 2004; 19:1023-1028
  • 22.Ferraris A, D'Amato G, Nobili V, Torres B, Marcellini M, Dallapiccola B. Combined test for UGT1A1-3279T-->G and A(TA)nTAA polymorphisms best predicts Gilbert's syndrome in Italian pediatric patients. Genet Test. 2006;10:121-125
  • 23.Watchko JF, Daood MJ, Biniwale M. Understanding neonatal hyperbilirubinaemia in the era of genomics. Semin Neonatol. 2002;7:143-152
  • 24.Tuygun N, Tıraş Ü, Şıklar Z, Erdeve Ö, Tanyer G, Dallar Y. Yenidoğan uzamış sarılığının etyolojik yönden değerlendirilmesi ve anne sütü sarılığı. Türk Pediatri Arşivi. 2002;23:138-143
  • 25.Kale G, Coşkun Y, Yurdakök M. Pediatride Tanı ve Tedavi Hacettepe Uygulamaları. Ankara, Güneş Kitabevi, 2009;925-928

Yeni doğan bebeklerde uzamış sarılık

Year 2009, Volume: 15 Issue: 2, 49 - 55, 01.03.2009

Ercan Sivaslı

Abstract

Yenidoğan bebeklerin yaklaşık %50'sinde sarılık gelişmektedir. Serum bilirubin düzeyi erişkinlerde 2 mg/dl'nin, yenidoğanlarda 6 mg/dl'nin üzerinde ise sarılık gözle görülebilir hale gelmektedir. Matür bebeklerde 14 günü, prematur bebeklerde ise 21 günü geçen 10 mg/dl üzerinde olan bir hiperbilirubinemi varlığı uzamış sarılık olarak tanımlanır. Uzamış sarılıkta hem direkt, hemde indirekt bılirübin yükselmiş olabilir. Özellikle direkt bilirubin yüksekliği olan uzamış sarılık ciddi karaciğer hastalıklarının belirtisi olabilir. Bu nedenle, bu derlemede, yenidoğan döneminde görülen uzamış sarılık nedenleri ve tedavisi gözden geçirilecektir.

Keywords

Yenidoðan Hiperbilirubinemi Uzamýþ Sarýlýk

References

  • l.Watchko JF, Maisels MJ. Neonatal jaundice. Semin Neonatal. 2002;7:101-103
  • 2.Wong RJ, DeSandre GH, Sibley E, Stevenson DK. Neonatal jaundice and liver disease. In: Fanaroff AA, Martin R3 (eds). Neonatal-Perinatal Medicine Disease of the Fetus and Infant. 2006;8(l):1419-1466
  • 3.Porter ML, Dennis BL. Hyperbilirubinemia in the matür newborn. Ame Fmly Phys. 2002;65:599-606
  • 4.Hannam S, McDonnell M, Rennie JM. Investigation of prolonged nenatal jaundice. Acta Paediatr. 2000;89:694-697
  • 5.Mishra S, Agarwal R, Deorari AK, Paul VK. Jaundice in the newboms. Indian J Pediatr. 2008;75:157-163
  • 6.McKiernan PJ. Neonatal cholestasis. Semin Neonatol. 2002:7; 153-157
  • 7-McKiernan PJ, Baker AJ, Kelly DA. The frequency and outcome of biliary atresia in the UK and Ireland. Lancet. 2000;355:25-29
  • 8.Newman AJ, Gross S. Hyperbilirubinemia in breast- fed infants. Pediatrics. 1963;32:995-1001
  • 9.Lawrence M. Gartner, MD. Breastfeeding and Jaundice. J Perinatol. 2001;21:25-29
  • 10.Gartner LM. Neonatal jaundice. Pediatr Rev. 1994;15:422
  • ll.Sarici SU, Saldir M. Genetic factors in neonatal hyperbilirubinemia and kernicterus. Turk J Pediatr. 2007;49:245-249
  • 12-Gourley GR, Li Z, Kreamer BL, Kosorok MR. A controlled, randomized, double-blind trial of prophylaxis against jaundice among breastfed newborns. Pediatrics. 2005;116:385-39.1
  • 13.Yiğit S, Ciliv G, Aygün C, Erdem G. Breast milk beta-glucuronidase levels in hyperbilirubinemia. Turk J Pediatr. 2001;43:118-20
  • 14.İnce Z, Çoban A, Peker I, Can G. Breast milk -glucuronidase and prolonged jaundice in the neonate. Acta Paediatr. 1995;84:237-239
  • 15.Erdem G, Öztürk R, Ciliv G, Özmert E, Tuncer M. Is beta-glucuronidase a contributory factor in early indirect hyperbilirubinemia. Acta Paediatr. 1997;86:120
  • 16.Maruo Y, Nishizawa K, Sato H, Sawa H, Shİmada M. Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene. Pediatrics 2000;106:59
  • 17.Frank 3E. Diagnosis and Management of G6PD Deficiency. Am Fam Physician. 2005;72:1277-1282
  • 18-Francisco J. Garcia and Alan L. Nager. Jaundice as an Early Diagnostic Sign of Urinary Tract Infection in Infancy. Pediatrics. 2002; 109)846-851
  • 19.Pashapour N, Nikibahksh AA, Golmohammadlou S. Urinary tract infection in matiir neonates with prolonged jaundice. Urol J. 2007;4:91-94
  • 2O.Bilgen H, Ozek E, UnverT, Biyikli N, Alpay H, Cebeci D. Urinary tract infection and hyperbilirubinemia. Turk J Pediatr. 2006;48:51-55
  • 21.Takeuchi K, Kobayashi Y, Tamaki S, Ishihara T, Maruo Y, Araki J, et al. Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects. J Gastroenterol Hepatol. 2004; 19:1023-1028
  • 22.Ferraris A, D'Amato G, Nobili V, Torres B, Marcellini M, Dallapiccola B. Combined test for UGT1A1-3279T-->G and A(TA)nTAA polymorphisms best predicts Gilbert's syndrome in Italian pediatric patients. Genet Test. 2006;10:121-125
  • 23.Watchko JF, Daood MJ, Biniwale M. Understanding neonatal hyperbilirubinaemia in the era of genomics. Semin Neonatol. 2002;7:143-152
  • 24.Tuygun N, Tıraş Ü, Şıklar Z, Erdeve Ö, Tanyer G, Dallar Y. Yenidoğan uzamış sarılığının etyolojik yönden değerlendirilmesi ve anne sütü sarılığı. Türk Pediatri Arşivi. 2002;23:138-143
  • 25.Kale G, Coşkun Y, Yurdakök M. Pediatride Tanı ve Tedavi Hacettepe Uygulamaları. Ankara, Güneş Kitabevi, 2009;925-928
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ercan Sivaslı This is me

Publication Date March 1, 2009
Published in Issue Year 2009 Volume: 15 Issue: 2

Cite

APA Sivaslı, E. (2009). Yeni doğan bebeklerde uzamış sarılık. Gaziantep Medical Journal, 15(2), 49-55.
AMA Sivaslı E. Yeni doğan bebeklerde uzamış sarılık. Gaziantep Medical Journal. March 2009;15(2):49-55.
Chicago Sivaslı, Ercan. “Yeni doğan Bebeklerde uzamış sarılık”. Gaziantep Medical Journal 15, no. 2 (March 2009): 49-55.
EndNote Sivaslı E (March 1, 2009) Yeni doğan bebeklerde uzamış sarılık. Gaziantep Medical Journal 15 2 49–55.
IEEE E. Sivaslı, “Yeni doğan bebeklerde uzamış sarılık”, Gaziantep Medical Journal, vol. 15, no. 2, pp. 49–55, 2009.
ISNAD Sivaslı, Ercan. “Yeni doğan Bebeklerde uzamış sarılık”. Gaziantep Medical Journal 15/2 (March 2009), 49-55.
JAMA Sivaslı E. Yeni doğan bebeklerde uzamış sarılık. Gaziantep Medical Journal. 2009;15:49–55.
MLA Sivaslı, Ercan. “Yeni doğan Bebeklerde uzamış sarılık”. Gaziantep Medical Journal, vol. 15, no. 2, 2009, pp. 49-55.
Vancouver Sivaslı E. Yeni doğan bebeklerde uzamış sarılık. Gaziantep Medical Journal. 2009;15(2):49-55.