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A general overview to physiological and morphological changes and developments

Year 2009, Volume: 15 Issue: 2, 56 - 65, 01.03.2009

Abstract

Presbycusis (age-related hearing loss) is one of the principal communicative and chronic medical disorders of our aged population. Preventative and curative biomedical interventions provide us with an understanding of the basis of this neural and molecular sensory deficit. The cochlear nucleus (CN) receives the outputs of the auditory portion of the inner ear, and sends these outputs to the centres where critical sound and perception analyses are conducted in parallel processing pathways of brainstem. This location plays a key role to process the sound. This location is an important place to investigate the structural and functional changes related to aging occuring in cochlear nucleus. Our goal is to reveal the neurophysiologic bases of functional changes which occur in mammalian CN related to aging.

References

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Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış

Year 2009, Volume: 15 Issue: 2, 56 - 65, 01.03.2009

Abstract

Presbikuzi (yaşlanmaya bağlı olarak işitme gücünün azalması); yaşlanmış insanlarımızın başta gelen iletişimsel ve kronik tıbbi bozukluğudur. Önleyici ve iyileştirici biyomedikal girişimler sadece, bu duyu kaybının sinirsel ve moleküler temelini anlamamızı sağlar. Koklear nukleus (KN); iç kulağın, işitme duyusuna ait kısmının çıktılarını alır ve beyin sapındaki paralel işleme yollarında kritik ses analizi ve algılama yapılan merkezlere aktarır. Sesin işleme tabi tutulması için bu bölge, anahtar bir rol oynar. Bu bölge yaşlanmaya bağlı olarak KN'de meydana gelen yapısal ve fonksiyonel değişiklikleri incelemek için önemli bir yerdir. Amacımız, memeli KN'sinde yaşlanmaya bağlı olarak meydana gelen fonksiyonel değişikliklerin nörofizyolojik temellerini ortaya koymaktır.

References

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  • 2.Syka J. Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning. Physiol Rev. 2002;82:601-636
  • 3.Thomas A, Herbst KG Social and psychological implications of acquired deafness for adults of employment age. Br J Audiol. 1980;14:76-85
  • 4.Weinstein BE, Ventry IM. Hearing impairment and social isolation in the elderly. J Speech Hear Res. 1982;25:593-599
  • 5.Mulrow CD, Aguilar C, Endicott JE, Tuley MR, Velez R, Charlip WS, et al. Quality-of-life changes and hearing impairment: a randomized trial. Ann Intern Med. 1990;113:188-194
  • 6.Gordon-Salant S, Fitzgibbons PJ. Temporal factors and speech recognition performance in young and elderly listeners. J Speech Hear Res. 1993;36:1276-1285
  • 7.Frisina DR, Frisina RD. Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res. 1997; 106:95-104
  • 8.Caspary DM, Schatteman TA, Hughes LF. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. The J Neurosci. 2005;25(47): 10952-10959
  • 9.Frisina RD, Walton JP. Age-related structural and functional changes in the cochlear nucleus. Hear Res. 2006;216-217:216-223
  • lO.Schuknecht H. Pathology of the ear. Cambridge, MA, Harward University Press, 1974;388-403
  • ll.Schuknecht HF. Pathology of presbycusis. In, Goldstein JC, Kashima, HK and Koopman CF (eds), Geriatric Otorhinolaryngology. Inc., Toronto and Philadelphia, BD Decker, 1989;40-44
  • 12.Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol. 1993;102:l-16
  • 13.Liu XZ, Yan D. Ageing and hearing loss. J Pathol. 2007;21:188-197
  • 14.Arnesen AR. Presbycusis - loss of neurons in the human cochlear nuclei. J Laryngol Otol. 1982;96:503-511
  • 15.Welsh LW, Welsh JJ, Healy MP. Central presbycusis. The Laryngol. 1985;95:128-136
  • 16.Willott JF, Bross LS, McFadden SL Morphology of the dorsal cochlear nucleus in C57BL/6J and CBA/J mice across the life span. J Comp Neurol. 1992;32:666-678
  • 17.Hawkins JE, Miller JM, Rouse RC, Davis JA, Rarey K. Inner ear histopathology in aging rhesus monkeys (Maçaca mulatta). In, Davis RT and Leathers CW (eds) Behavior and Pathology of Aging in Rhesus Monkeys. Alan R. Liss, Inc., New York. 1985; 137-154
  • 18.Dayal VS, Bhattacharyya TK. Comparative study of age-related cochlear hair cell loss. Ann Otol Rhinol Laryngol. 1986;95:510-513
  • 19.Henry KR, Chole RA. Genotypic differences in behavioral, physiological and anatomical expressions of age-related hearing loss in the laboratory mouse. Audiology. 1980; 19:369-383
  • 2O.Keithley EM,Feldman ML. Hair cell counts in an age-graded series of rat cochleas. Hear Res. 1982;8:249-262
  • 21.Bhattacharyya TK, Dayal VS. Age-related cochlear hair cell loss in the chinchilla. Ann Otol Rhinol Laryngol. 1985;94:75-80
  • 22.Bonne BA, Gruner MM, Harding GW. Morphological correlates of aging in the chinchilla cochlea. Hear Res. 1990;48:79-92
  • 23.Bhattacharyya TK, Dayal VS. Influence of age on hair cell loss in the rabbit cochlea. Hear Res. 1989;40:179-184
  • 24.Coleman JW. Hair cell loss as a function of age in the normal cochlea of the guniea pig. Acta Otolaryngol. 1976;82:33-40
  • 25.Shimada A, Ebisu M, Morita T, Takeuchi T, Umemura T. Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs. J Vet Med Sci. 1998;60(l):41-48
  • 26.Dubno JR, Dirks DD, Morgan DE. Effects of age and mild hearing loss on speech recognition in noise. J Acoust Soc Am. 1984;76:87-96
  • 27.Moore BC, Peters RW, Glasberg BR. Detection of temporal gaps in sinusoids by elderly subjects with and without hearing loss. J Acoust Soc Am. 1992;92:1923-1932
  • 28.Fitzgibbons PJ, Gordon-Salant S. Age effects on measures of auditory duration discrimination. J Speech Hear Res. 1994;37:662-670
  • 29.Schneider BA, Pichora-Fuller MK, Kowalchuk D, Lamb M. Gap detection and the precedence effect in young and old adults. J Acoust Soc Am. 1994;95:980-991
  • 30-Snell KB. Age-related changes in temporal gap detection. J Acöust Soc Am. 1997;101:2214-2220
  • 31.Strouse A, Ashmead DH, Ohde RN, Grantham DW. Temporal processing in the aging auditory system. J Acoust Soc Am. 1998; 104:2385-2399
  • 32.Tremblay KL, Piskosz M, Souza P. Aging alters the neural representation of speech cues. Neuro Report. 2002; 13:1865-1870
  • 33.Tremblay KL, Piskosz M, Souza P. Effects of age and age-related hearing loss on the neural representation of speech cues. Clin Neurophysiol. 2003;114:1332-1343
  • 34.Ostroff JM, McDonald KL, Schneider BA, Alain C. Aging and the processing of sound duration in human auditory cortex. Hear Res. 2003; 181:1-7
  • 35.Caspary DM, Raza A, Lawhorn Armour BA, Pippin J, Arneric SP. Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis. J Neurosci. 1990;10:2363-2372
  • 36.Caspary DM, Backoff PM, Finlayson PG, Palombi PS. Inhibitory inputs modulate discharge rate within frequency receptive fields of anteroventral cochlear nucleus. J Neurophysiol. 1994;72:2124-2133
  • 37.Caspary DM, Milbrandt JC, Helfert RH. Central auditory aging: GABA changes in the inferior colliculus. Exp Gerontol. 1995;30:349-360
  • 38.Schmolesky MT, Wang Y, Pu M, Leventhal AG. Degradation of stimulus selectivity of visual cortical cells in senescent rhesus monkeys. Nat Neurosci. 2000;3:384-390
  • 39.Caspary DM, Salvi PJ, Helfert RH, Brozoski TJ, Bauer CA. Neuropharmacology of noise induced hearing loss in brainstem auditory structures. In: Noise induced hearing loss: mechanisms of damage and means of prevention. Henderson D, Prasher D, Kopke R, Salvi RJ, Hamernik R. (eds), London: NRN. 2001;169-186
  • 40.Mendelson JR, Ricketts C. Age-related temporal processing speed deterioration in auditory cortex. Hear Res. 2001; 158:84-94
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There are 103 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Mehmet Boşnak This is me

Ayhan Eralp This is me

Publication Date March 1, 2009
Published in Issue Year 2009 Volume: 15 Issue: 2

Cite

APA Boşnak, M., & Eralp, A. (2009). Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal, 15(2), 56-65.
AMA Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. March 2009;15(2):56-65.
Chicago Boşnak, Mehmet, and Ayhan Eralp. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal 15, no. 2 (March 2009): 56-65.
EndNote Boşnak M, Eralp A (March 1, 2009) Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal 15 2 56–65.
IEEE M. Boşnak and A. Eralp, “Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış”, Gaziantep Medical Journal, vol. 15, no. 2, pp. 56–65, 2009.
ISNAD Boşnak, Mehmet - Eralp, Ayhan. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal 15/2 (March 2009), 56-65.
JAMA Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. 2009;15:56–65.
MLA Boşnak, Mehmet and Ayhan Eralp. “Fizyolojik Ve Morfolojik değişmeler Ve gelişmelere Genel Bir bakış”. Gaziantep Medical Journal, vol. 15, no. 2, 2009, pp. 56-65.
Vancouver Boşnak M, Eralp A. Fizyolojik ve morfolojik değişmeler ve gelişmelere genel bir bakış. Gaziantep Medical Journal. 2009;15(2):56-65.