Deksmedetomidin ve fentanil propofol enjeksiyon ağrısını gideriyor

Year 2009, Volume: 15 Issue: 3, 17 - 22, 01.04.2009

Ayşe Mızrak Senem Koruk Rauf Gül Süleyman Ganidağlı Şemsettin Bozgeyik Ünsal Öner

Abstract

We performed this study to compare the effects of intravenous dexmedetomidine and fentanyl on propofof injection pain. We conducted a prospective, randomized and double blind study of 120 adult unpremedicated patients (18-65 years of age) scheduled to undergo elective surgery under general anesthesia. The patients were allocated randomly into three groups (n=40): fentanyl (F), dexmedetomidine (D), and Control (C). Ten ml of the study solution was injected over 10 seconds. One minute after the administration of fentanyl (1 ug/ kg) or dexmedetomidine (0,15 ug/ kg) or placebo, propofol 2,5 mg/ kg was Infused at a rate of 20 ml/ min. Injection pain was assessed using a four - point verbal rating scale. The incidence of propofol-associated injection pain were 65% (26) for group C, 27% (16) for group F, and 25% (10) for group D. The incidence of pain were less in the"fentanyl, and especially in the dexmedetomidine groups than control group (p< 0.05). Severe pain in groups were D

Keywords

Dexmedetomidine, Fentanyl, Propofol, Injections, Anesthesia, Intravenous, Premedication, Pain, Hemodynamics, Analgesics

Deksmedetomidin and fentanyl attenuatethe propofol injection pain

Abstract

Bu çalışmayı, venöz yol ile verilen deksmedetomidin ve fentanilin propofol enjeksiyon ağrısı üzerine olan etkisini karşılaştırmak üzere gerçekleştirdik. Genel anestezi altında elektif cerrahi geçirecek olan, premedikasyon yapılmamış (18-65 yaş), yetişkin hasta ile bir prospektif, randomize ve çift kör çalışma planladık. Hastalar gelişigüzel 3 gruba ayrıldı (n=40)- Fentanil (F), deksmedetomidin (D) ve Kontrol (C). 10 mililitrelik çalışma solüsyonu sabit 10 saniye içinde enjekte edildi. Fentanil (1 ug/ kg) ya da deksmedetomidin (0.15 ug/ kg) ya da plasebo verildikten 60 saniye sonra propofol 2,5 mg/kg 20 ml/ dakika hızla infuze edildi Enjeksiyon ağrısı four-point sözel skalası kullanılarak değerlendirildi Propofol ilişkili enjeksiyon ağrısının oranları grup C için. %65 (26), F grubu için: %27 (16) ve grup D için %25 (10) idi. Ağrı oranı fentanil ve özellikle de deksmedetomidin grubunda kontrol grubuna göre daha azdı (p< 0.05). Gruplardakı şiddetli ağrı, D

Keywords

Deksmedetodimin, Fentanil, Propofol, Enjeksiyonlar, Anestezi, ven içi, Premedikasyon, Ağrı, Hemodinamikler, Analjezikler

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