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Vitamin K and osteoporosis

Year 2011, Volume: 17 Issue: 1, 1 - 7, 01.02.2011

Abstract

Vitamin K is involved in blood coagulation and in bone metabolism via the carboxylation of glutamate residues in (hepatic) blood coagulation factors and (osteoblastic) bone proteins. Although undercarboxylation of blood coagulation factors is very rare, undercarboxylated osteocalcin (bone Gla-protein) is frequently found in subject with osteoporosis. Osteoporosis, a systemic disease characterized by a low bone mass, is a major public health problem. It is a devastating disorder with significant physical, psychosocial, and financial problems because of the high incidence of fragility fractures, especially hip and vertebral fracture. The high incidence of osteoporotic fractures leads to considerable mortality, morbidity, reduced mobility and decreased quality of life. Hence one of the most important approaches to therapy is prevention. Supplementation of osteoporotic subjects with extra vitamin K causes the markers for bone formation to increase. In parallel, a decrease of the markers for bone resorption is frequently seen, Because of vitamin K can be decreased the risk of developing osteoporosis and its complications can be minimized. In this review summarizes with a theoretical knowledge about vitamin K and osteoporosis plus current reports regarding a possible role of vitamin K insufficiency in the pathogenesis of osteoporosis.

References

  • 1. New AS. Bone health: the role of micronutrients. Br Med Bull 1999;55(3):619-33
  • 2. Plaza SM, Lamson DW. Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev 2005;10(1):24-35
  • 3. Monographs. Vitamin K2. Altern Med Rev 2009;14(3):284-93
  • 4. Vermeer C, Knapen MHJ, Schurgers LJ. Vitamin K and metabolic bone disease. Clin Pathol 1998;51:424-6
  • 5. Drevon CA, Henriksen HB, Sanderud M, Gundersen TE, Blomhoff R. Biological effects of vitamin K and concentration of vitamin K in Norwegian food. Tidsskr Nor Laegeforen 2004;124(24):3261-2
  • 6. McCormick RK. Osteoporosis: Integrating biomarkers and other diagnostic correlates into the management of bone fragility
  • Altern Med Rev 2007;12(2):113-45
  • 7. Ahmed S, Kishikawa N, Nakashima K, Kuroda N
  • Determination of vitamin K homologues by high-performance liquid chromatography with on-line photoreactor and peroxyoxalate chemiluminescence detection. Anal Chim Acta 2007;22:148-54
  • 8. Elçi A. Postmenapozal kadınlarda serum total osteokalsin ve gama karboksi glutamat kalıntısı taşımayan osteokalsin oranı ile kemik mineral dansitesi ölçümünün karşılaştırılması. Uzmanlık Tezi, İstanbul, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, 2004
  • 9. Tekin Y, Bozdemir AE, Barutçuoğlu B. Osteoporoz tanısında kullanılan biyokimyasal göstergeler. Türk Klinik Biyokimya Derg 2005;3(2):73-83
  • 10. Hara K, Akiyama Y, Nakamura T, Murota S, Morita I. The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone 1995;16(2):179-84
  • 11. Kameda T, Miyazawa K, Mori Y, Yuasa T, Shiokawa M, Nakamaru Y et al. Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem Biophys Res Commun 1996;220(3):515-9
  • 12. Weber P. Management of osteoporosis: Is there a role for vitamin K? Int J Vitam Nutr Res 1997;67(5):350-6
  • 13. Suzuki A, Sekiguchi S, Asano S, Itoh M. Pharmacological topics of bone metabolism: Recent advances in pharmacological management of osteoporosis. J Pharmacol Sci 2008;106:530-5
  • 14. Hosoi T. Clinical implications of undercarboxylated osteocalcin
  • Clin Calcium 2009;19(12):1815-21
  • 15. Saito M. Effect of vitamin K on bone material properties. Clin Calcium 2009;19(12):1797-804
  • 16. Uçan Ö. Taşçı S, Ovayolu N. Osteoporozda risk faktörleri ve korunmanın önemi. Fırat Sağlık Hizmetleri Derg 2007;2(6):73- 86
  • 17. Duman AE, Güven GS, Gürlek A. Erkek osteoporozu
  • Hacettepe Tıp Derg 2005;36:175-83
  • 18. Lee MS, Pittler MH, Shin BC, Ernst E. Tai chi for osteoporosis: a systematic review. Osteoporos Int 2008;19(2):139-46
  • 19. Ertungealp E, Seyisoglu H, Erel CT, Senturk LM, Gezer A
  • Changes in bone mineral density with age, menopausal status and body mass index in Turkish women. Climacteric 1999;2(1):45-51
  • 20. Johnell O. The socioeconomic burden of fractures: Today and in the 21st century. Am J Med 1997;18(103):20-5
  • 21. Olson RE. Osteoporosis and vitamin K intake. Am J Clin Nutr 2000;71(5):1031-2
  • 22. Luo LZ, Xu L. Vitamin K and osteoporosis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003;25(3):346-9
  • 23. Yamaguchi M. Regulary mechanism of food factors in bone metabolism and prevention of osteoporosis. Yakugaku Zasshi 2006;126(1):1117-37
  • 24. Akiyama Y, Hara K, Ohkawa I, Tajima T. Effects of menatetrenone on bone loss induced by ovariectomy in rats. Jpn J Pharmacol 1993;62(2):145-53
  • 25. Kobayashi M, Hara K, Akiyama Y. Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats. Jpn J Pharmacol 2002;88(1):55-61
  • 26. Sun L, Tamaki H, Ohta Y, Katsuyama Y, Ishimaru T, Chinen I
  • Inhibition of osteoporosis induced by protein deficient (PD) food intake by active vitamin D3 and vitamin K2 in rats. Biosci Biotechnol Biochem 2004;68(6):1385-7
  • 27. Iwamato J, Takeda T, Sato Y. Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis
  • Nutr Rev 2006;64(12):509-17
  • 28. Knapen MHJ, Hamulyák K, Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone gla protein) and urinary calcium excretion. Ann Intern Med 1989;111:1001-5
  • 29. Szulc P, Chapuy MC, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 1993;91:1769-74
  • 30. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr 1999;69:74-9
  • 31. Weber P. The role of vitamins in the prevention of osteoporosis-a brief status report. Int J Vitam Nutr Res 1999;69(3):194-7
  • 32. Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O'Fallon WM, Castro MR, et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 1999;159(15):1750-6
  • 33. Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in adults. JAMA 2002;287:3116-26
  • 34. Iwamato J, Takeda T, Ichimura S. Combined treatment with vitamin K2 and biphosphonate in postmenaposal woman with osteoporosis. Yonsei Med J 2003;44(5):751-6
  • 35. Ryan-Harshman M, Aldoori W. Bone health, New role for vitamin K? Can Fam Physician 2004;50:993-7
  • 36. Iwamoto J, Takeda T, Sato Y. Prevention and treatment of corticosteroid-induced osteoporosis. Yonsei Med J 2005;46(4):456-63
  • 37. Knapen MHJ, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 2007;18:963-72
  • 38. Sugiyama T, Takaki T, Saito T, Taguchi T. Vitamin K therapy for cortical bone fragility caused by reduced mechanical loading in a child with hemiplegia. J Musculoskelet Neuronal Interact 2007;7(3):219-23
  • 39. Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, et al. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): A randomized controlled trial
  • PLoS Med 2008;5(12):1461-72
  • 40. Booth SL, Dallal G, Shea MK, Gundberg C, Peterson JW, Dawson-Hughes B. Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab 2008;93(4):1217-23
  • 41. Binkley N, Harke J, Krueger D, Engelke J, Vallarta-Ast N, Gemar D, et al. Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. J Bone Miner Res 2009;24(6):983-91
  • 42. Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, et al. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. J Nutr Sci Vitaminol (Tokyo) 2009;55(1):15-21
  • 43. Holzer G, Grasse AV, Zehetmayer S, Bencur P, Bieglmayer C, Mannhalter C. Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study. Transl Res 2010;156(1):37-44
  • 44. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 2000;71:1201-8
  • 45. Iwamoto J. Anti-fracture efficacy of vitamin K. Clin Calcium 2009;19(12):1805-14.

K vitamini ve osteoporoz

Year 2011, Volume: 17 Issue: 1, 1 - 7, 01.02.2011

Abstract

K vitamini kan koagülasyon faktörleri (hepatik) ve kemik proteinlerindeki (osteoblastik) glutamat artıklarının karboksilasyonu yoluyla, kan koagülasyonu ve kemik metabolizmasında yer alır. Kan koagülasyon faktörlerinin karboksillenmemiş formu çok az görülse de, karboksillenmemiş ostekalsin (kemik Gla-proteini) osteoporozlu olgularda sıklıkla görülmektedir. Osteoporoz düşük kemik kütlesi ile karekterize olan önemli bir halk sağlığı sorunudur. Özellikle kalça ve omurgada yüksek oranda frajil kırıklara sebep olduğundan, önemli fiziksel, psikososyal ve ekonomik problemlere yol açan zor bir hastalıktır. Osteoporotik kırıkların bu yüksek oranı önemli ölçüde mortalite, morbidite, hareket kısıtlaması ve hayat kalitesinin düşmesine yol açar. Bundan dolayı tedaviye en önemli yaklaşım hastalıktan korunmadır. K vitamini destek tedavisi verilen osteoporozlu kişilerde, sıklıkla kemik yapım belirteçlerinde artış, bunun paralelinde kemik yıkım belirteçlerinde azalma görülmüştür. Bu sebepten K vitamini osteoporoz ge lişme riskini azaltabileceği ve komplikasyonlarını minumuma indirebileceği düşünülmektedir. Bu derlemede, K vitamini ve osteoporoz hakkında teorik bilgi ile birlikte osteoporozun patogenezinde K vitamini yetersizliğinin olası rolü hakkında son veriler sunulmuştur.

References

  • 1. New AS. Bone health: the role of micronutrients. Br Med Bull 1999;55(3):619-33
  • 2. Plaza SM, Lamson DW. Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev 2005;10(1):24-35
  • 3. Monographs. Vitamin K2. Altern Med Rev 2009;14(3):284-93
  • 4. Vermeer C, Knapen MHJ, Schurgers LJ. Vitamin K and metabolic bone disease. Clin Pathol 1998;51:424-6
  • 5. Drevon CA, Henriksen HB, Sanderud M, Gundersen TE, Blomhoff R. Biological effects of vitamin K and concentration of vitamin K in Norwegian food. Tidsskr Nor Laegeforen 2004;124(24):3261-2
  • 6. McCormick RK. Osteoporosis: Integrating biomarkers and other diagnostic correlates into the management of bone fragility
  • Altern Med Rev 2007;12(2):113-45
  • 7. Ahmed S, Kishikawa N, Nakashima K, Kuroda N
  • Determination of vitamin K homologues by high-performance liquid chromatography with on-line photoreactor and peroxyoxalate chemiluminescence detection. Anal Chim Acta 2007;22:148-54
  • 8. Elçi A. Postmenapozal kadınlarda serum total osteokalsin ve gama karboksi glutamat kalıntısı taşımayan osteokalsin oranı ile kemik mineral dansitesi ölçümünün karşılaştırılması. Uzmanlık Tezi, İstanbul, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, 2004
  • 9. Tekin Y, Bozdemir AE, Barutçuoğlu B. Osteoporoz tanısında kullanılan biyokimyasal göstergeler. Türk Klinik Biyokimya Derg 2005;3(2):73-83
  • 10. Hara K, Akiyama Y, Nakamura T, Murota S, Morita I. The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone 1995;16(2):179-84
  • 11. Kameda T, Miyazawa K, Mori Y, Yuasa T, Shiokawa M, Nakamaru Y et al. Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem Biophys Res Commun 1996;220(3):515-9
  • 12. Weber P. Management of osteoporosis: Is there a role for vitamin K? Int J Vitam Nutr Res 1997;67(5):350-6
  • 13. Suzuki A, Sekiguchi S, Asano S, Itoh M. Pharmacological topics of bone metabolism: Recent advances in pharmacological management of osteoporosis. J Pharmacol Sci 2008;106:530-5
  • 14. Hosoi T. Clinical implications of undercarboxylated osteocalcin
  • Clin Calcium 2009;19(12):1815-21
  • 15. Saito M. Effect of vitamin K on bone material properties. Clin Calcium 2009;19(12):1797-804
  • 16. Uçan Ö. Taşçı S, Ovayolu N. Osteoporozda risk faktörleri ve korunmanın önemi. Fırat Sağlık Hizmetleri Derg 2007;2(6):73- 86
  • 17. Duman AE, Güven GS, Gürlek A. Erkek osteoporozu
  • Hacettepe Tıp Derg 2005;36:175-83
  • 18. Lee MS, Pittler MH, Shin BC, Ernst E. Tai chi for osteoporosis: a systematic review. Osteoporos Int 2008;19(2):139-46
  • 19. Ertungealp E, Seyisoglu H, Erel CT, Senturk LM, Gezer A
  • Changes in bone mineral density with age, menopausal status and body mass index in Turkish women. Climacteric 1999;2(1):45-51
  • 20. Johnell O. The socioeconomic burden of fractures: Today and in the 21st century. Am J Med 1997;18(103):20-5
  • 21. Olson RE. Osteoporosis and vitamin K intake. Am J Clin Nutr 2000;71(5):1031-2
  • 22. Luo LZ, Xu L. Vitamin K and osteoporosis. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003;25(3):346-9
  • 23. Yamaguchi M. Regulary mechanism of food factors in bone metabolism and prevention of osteoporosis. Yakugaku Zasshi 2006;126(1):1117-37
  • 24. Akiyama Y, Hara K, Ohkawa I, Tajima T. Effects of menatetrenone on bone loss induced by ovariectomy in rats. Jpn J Pharmacol 1993;62(2):145-53
  • 25. Kobayashi M, Hara K, Akiyama Y. Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats. Jpn J Pharmacol 2002;88(1):55-61
  • 26. Sun L, Tamaki H, Ohta Y, Katsuyama Y, Ishimaru T, Chinen I
  • Inhibition of osteoporosis induced by protein deficient (PD) food intake by active vitamin D3 and vitamin K2 in rats. Biosci Biotechnol Biochem 2004;68(6):1385-7
  • 27. Iwamato J, Takeda T, Sato Y. Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis
  • Nutr Rev 2006;64(12):509-17
  • 28. Knapen MHJ, Hamulyák K, Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone gla protein) and urinary calcium excretion. Ann Intern Med 1989;111:1001-5
  • 29. Szulc P, Chapuy MC, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 1993;91:1769-74
  • 30. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr 1999;69:74-9
  • 31. Weber P. The role of vitamins in the prevention of osteoporosis-a brief status report. Int J Vitam Nutr Res 1999;69(3):194-7
  • 32. Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O'Fallon WM, Castro MR, et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 1999;159(15):1750-6
  • 33. Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in adults. JAMA 2002;287:3116-26
  • 34. Iwamato J, Takeda T, Ichimura S. Combined treatment with vitamin K2 and biphosphonate in postmenaposal woman with osteoporosis. Yonsei Med J 2003;44(5):751-6
  • 35. Ryan-Harshman M, Aldoori W. Bone health, New role for vitamin K? Can Fam Physician 2004;50:993-7
  • 36. Iwamoto J, Takeda T, Sato Y. Prevention and treatment of corticosteroid-induced osteoporosis. Yonsei Med J 2005;46(4):456-63
  • 37. Knapen MHJ, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 2007;18:963-72
  • 38. Sugiyama T, Takaki T, Saito T, Taguchi T. Vitamin K therapy for cortical bone fragility caused by reduced mechanical loading in a child with hemiplegia. J Musculoskelet Neuronal Interact 2007;7(3):219-23
  • 39. Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, et al. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): A randomized controlled trial
  • PLoS Med 2008;5(12):1461-72
  • 40. Booth SL, Dallal G, Shea MK, Gundberg C, Peterson JW, Dawson-Hughes B. Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab 2008;93(4):1217-23
  • 41. Binkley N, Harke J, Krueger D, Engelke J, Vallarta-Ast N, Gemar D, et al. Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. J Bone Miner Res 2009;24(6):983-91
  • 42. Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, et al. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. J Nutr Sci Vitaminol (Tokyo) 2009;55(1):15-21
  • 43. Holzer G, Grasse AV, Zehetmayer S, Bencur P, Bieglmayer C, Mannhalter C. Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study. Transl Res 2010;156(1):37-44
  • 44. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 2000;71:1201-8
  • 45. Iwamoto J. Anti-fracture efficacy of vitamin K. Clin Calcium 2009;19(12):1805-14.
There are 53 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Siber Emine Namıduru This is me

Mehmet Tarakçıoğlu This is me

Publication Date February 1, 2011
Published in Issue Year 2011 Volume: 17 Issue: 1

Cite

APA Namıduru, S. E., & Tarakçıoğlu, M. (2011). K vitamini ve osteoporoz. Gaziantep Medical Journal, 17(1), 1-7.
AMA Namıduru SE, Tarakçıoğlu M. K vitamini ve osteoporoz. Gaziantep Medical Journal. February 2011;17(1):1-7.
Chicago Namıduru, Siber Emine, and Mehmet Tarakçıoğlu. “K Vitamini Ve Osteoporoz”. Gaziantep Medical Journal 17, no. 1 (February 2011): 1-7.
EndNote Namıduru SE, Tarakçıoğlu M (February 1, 2011) K vitamini ve osteoporoz. Gaziantep Medical Journal 17 1 1–7.
IEEE S. E. Namıduru and M. Tarakçıoğlu, “K vitamini ve osteoporoz”, Gaziantep Medical Journal, vol. 17, no. 1, pp. 1–7, 2011.
ISNAD Namıduru, Siber Emine - Tarakçıoğlu, Mehmet. “K Vitamini Ve Osteoporoz”. Gaziantep Medical Journal 17/1 (February 2011), 1-7.
JAMA Namıduru SE, Tarakçıoğlu M. K vitamini ve osteoporoz. Gaziantep Medical Journal. 2011;17:1–7.
MLA Namıduru, Siber Emine and Mehmet Tarakçıoğlu. “K Vitamini Ve Osteoporoz”. Gaziantep Medical Journal, vol. 17, no. 1, 2011, pp. 1-7.
Vancouver Namıduru SE, Tarakçıoğlu M. K vitamini ve osteoporoz. Gaziantep Medical Journal. 2011;17(1):1-7.