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Our initial experiences related to gamma probe use in completion thyroidectomy

Year 2011, Volume: 17 Issue: 2, 87 - 91, 01.03.2011

Abstract

In this study twenty two differentiated thyroid carcinoma (DTC) case performed completion thyroidectomy between June 2008 and October 2010 in Gaziantep University Medical Faculty Hospital were examined prospectively and surgical results of gamma probe were observed. Patients who had less then total thyroidectomy in their first operations with DTC pathology reports, went through gamma probe supported completion thyroidectomy, gamma probe efficiency was examined. In preoperative period, mean TSH value was identified as 1.48 mIU/l. 0.1mCi liquid I-131 was given to the patients after minimum 2 hours of starvation period one day before the day of surgery. All the areas where there was a signal over the background values were resected out from thyroid channel. While mean background radiation value was 24.04 cps (2-49) and mean basal radiation value of thyroid lodge was 753.09 cps (29-5156), after resection mean radiation value of thyroid lodge was measured as 13.4 cps (1-47). Postoperative TSH blood level before suppression therapy was measured as 52.86 mIU/l average. In post operative period all patients' (100%) thyroglobulin levels decreased. In the operations supported by gamma probe, we did not observe any increase in complication rates compared to literature. These results suggest that completion total thyroidectomy with gamma probe makes post operative treatment and follow up easier by providing more efficient surgical resection, and also completion thyroidectomy with gamma probe is the most efficient method in avoiding recurrences.

References

  • 1. Hurng, Song-Wu J, Young MD, Clark OH, in.: İşgör A, Tiroid Hastalıkları ve Cerrahisi, 1. baskı, İstanbul, Avrupa Tıp Kitapçılık, 2000:367-81.
  • 2. Tezelman S, Borucu I, Senyurek Giles Y, Tunca F, Terzioglu T. The change in surgical practice from subtotal to near-total or total thyroidectomy in the treatment of patients with benign multinodular goiter. World J Surg 2009;33(3):400-5.
  • 3. Mittendorf EA, McHenry CR. Thyroidectomy for selected patients with thyrotoxicosis. Arch Otolaryngol Head Neck Surg 2001;127(1):61-5.
  • 4. Mishra A, Agarwal A, Agarwal G, Mishra SK. Total thyroidectomy for benign thyroid disorders in an endemic region. World J Surg 2001;25(3):307-10.
  • 5. Lefevre JH, Tresallet C, Leenhardt L, Jublanc C, Chigot JP, Menegaux F. Reoperative surgery for thyroid disease. Langenbecks Arch Surg 2007;392(6):685-91.
  • 6. Erbil Y, Barbaros U, Deveci U, Kaya H, Bozbora A, Ozbey N, et al. Gamma probe-guided surgery for revision thyroidectomy: in comparison with conventional technique. J Endocrinol Invest 2005;28(7):583-8.
  • 7. Bender O, Karyagar S, Levent Balci F, Yuney E, Kamali S, Ozpacaci T, et al. Gamma probe (99m)Tc-pertechnetate assisted completion thyroidectomy vs conventional thyroidectomy in differentiated thyroid carcinoma. Hell J Nucl Med 2009;12(2):138-41.
  • 8. Aras G, Gültekin SS, Küçük NO, Demirer S, Tuğ T. Intraoperative gamma probe guidance with 99mTcpertechnetate in the completion thyroidectomy. Ann Nucl Med 2009;23(5):421-6.
  • 9. Salvatori M, Ardito G, Pelizzo MR, Mariani G, Gross M, AlNahhas A, et al. Treatment of local and regional recurrences of differentiated thyroid cancer by radio-guided surgery with iodine-131. Nucl Med Rev Cent East Eur 2006;9(2):119-24.
  • 10. Van Tol KM, Jager PL, De Vries EG, Piers DA, Boezen HM, Sluiter WJ, et al. Outcome in patients with differentiated thyroid cancer with negative diagnostic whole-body scanning and detectable stimulated thyroglobulin. Eur J Endocrinol 2003;148(6):589-96.
  • 11. Alex JC, Krag DN, Harlow SP, Meijer S, Loggie BW, Kuhn J, et al. Localization of regional lymph node in melanomas of the head and neck. Arch Otolaryngol Head Neck Surg 1998;124(2):135-40.
  • 12. Giles Y, Boztepe H, Terzioğlu T, Tezelman S. The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goiter. Arch Surg 2004;139:179-82.
  • 13. Grant CS, Hay ID, Gough IR, Bergstralh EJ, Goellner JR, McConahey WM. Local recurrence in papillary thyroid carcinoma: is extent of surgical resection important? Surgery 1988;104(6):954-6
  • 14. Reeve TS, Delbridge L, Brady P, Crummer P, Smyth C. Secondary thyroidectomy: a twenty-year experience. World J Surg 1988;12(4):449-53.
  • 15. Levin KE, Clark AH, Duh QY, Demeure M, Siperstein AE, Clark OH. Reoperative thyroid surgery. Surgery 1992;111(6):604-9.
  • 16. Pezzullo L, Delrio P, Losito NS, Caracò C, Mozzillo N. Post operation complications after completion thyroidectomy for differentiated thyroid cancer. Eur J Surg Oncol 1997;23(3):215-8.
  • 17. De Jong SA, Demeter JG, Lawrence AM, Paloyan E. Necessity and safety of completion thyroidectomy for differentiated thyroid carcinoma. Surgery 1992;112(4):734-7

Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz

Year 2011, Volume: 17 Issue: 2, 87 - 91, 01.03.2011

Abstract

Gaziantep Üniversitesi Tıp Fakültesi Hastanesinde Haziran 2008 - Ekim 2010 tarihleri arasında tamamlayıcı tiroidektomi uygulanan 22 diferansiyel tiroid karsinomu olan olgu prospektif olarak incelenmiş, gamma prob ile yapılan cerrahi tedavinin sonuçları ele alınmıştır. İlk operasyonlarında subtotal veya totale yakın tiroidektomi uygulanmış, patoloji sonuçları iyi diferansiyel tiro id karsinomu gelen hastalara gamma prob destekli tamamlayıcı tiroidektomi uygulanmış, gamma probun etkinliği ortaya konulmaya çalışılmıştır. Preoperatif dönemde hastaların ortalama TSH değeri 1.48 mIU/l olarak tespit edildi. Ameliyattan 24 saat önce minimum 2 saat a çlık periyodundan sonra hastalara oral yolla 0.1 mCi sıvı I-131 verildi. Tiroid yatağından arka plan değeri üzerinde sinyal alınan tüm alanlar rezeke edildi. Operasyon başlangıcında arka plan ışıma değeri ortalama 24.04 cps (2-49), tiroid lojundan alınan bazal ışıma değeri ortalama 753.09 cps (29-5156) iken rezeksiyon sonrası lojdaki ışıma değerleri ortalama 13.4 cps (1-47) olarak ölçüldü. Postoperatif TSH kan seviyesi supresyon tedavisine başlanmadan önce ortalama 52.86 mIU/l olarak tespit edildi. Postoperatif dönemde tüm hastalarda (%100) tiroglobulin (Tg) seviyesi düştü. Gamma prob eşliğinde yapılan tamamlayıcı tiroidektominin daha etkin bir cerrahi rezeksiyon sağlayarak postoperatif tedavi ve takipleri kolaylaştırdığı, rekürrenslerin önlenmesinde en etkin yöntem olduğu görüşündeyiz.

References

  • 1. Hurng, Song-Wu J, Young MD, Clark OH, in.: İşgör A, Tiroid Hastalıkları ve Cerrahisi, 1. baskı, İstanbul, Avrupa Tıp Kitapçılık, 2000:367-81.
  • 2. Tezelman S, Borucu I, Senyurek Giles Y, Tunca F, Terzioglu T. The change in surgical practice from subtotal to near-total or total thyroidectomy in the treatment of patients with benign multinodular goiter. World J Surg 2009;33(3):400-5.
  • 3. Mittendorf EA, McHenry CR. Thyroidectomy for selected patients with thyrotoxicosis. Arch Otolaryngol Head Neck Surg 2001;127(1):61-5.
  • 4. Mishra A, Agarwal A, Agarwal G, Mishra SK. Total thyroidectomy for benign thyroid disorders in an endemic region. World J Surg 2001;25(3):307-10.
  • 5. Lefevre JH, Tresallet C, Leenhardt L, Jublanc C, Chigot JP, Menegaux F. Reoperative surgery for thyroid disease. Langenbecks Arch Surg 2007;392(6):685-91.
  • 6. Erbil Y, Barbaros U, Deveci U, Kaya H, Bozbora A, Ozbey N, et al. Gamma probe-guided surgery for revision thyroidectomy: in comparison with conventional technique. J Endocrinol Invest 2005;28(7):583-8.
  • 7. Bender O, Karyagar S, Levent Balci F, Yuney E, Kamali S, Ozpacaci T, et al. Gamma probe (99m)Tc-pertechnetate assisted completion thyroidectomy vs conventional thyroidectomy in differentiated thyroid carcinoma. Hell J Nucl Med 2009;12(2):138-41.
  • 8. Aras G, Gültekin SS, Küçük NO, Demirer S, Tuğ T. Intraoperative gamma probe guidance with 99mTcpertechnetate in the completion thyroidectomy. Ann Nucl Med 2009;23(5):421-6.
  • 9. Salvatori M, Ardito G, Pelizzo MR, Mariani G, Gross M, AlNahhas A, et al. Treatment of local and regional recurrences of differentiated thyroid cancer by radio-guided surgery with iodine-131. Nucl Med Rev Cent East Eur 2006;9(2):119-24.
  • 10. Van Tol KM, Jager PL, De Vries EG, Piers DA, Boezen HM, Sluiter WJ, et al. Outcome in patients with differentiated thyroid cancer with negative diagnostic whole-body scanning and detectable stimulated thyroglobulin. Eur J Endocrinol 2003;148(6):589-96.
  • 11. Alex JC, Krag DN, Harlow SP, Meijer S, Loggie BW, Kuhn J, et al. Localization of regional lymph node in melanomas of the head and neck. Arch Otolaryngol Head Neck Surg 1998;124(2):135-40.
  • 12. Giles Y, Boztepe H, Terzioğlu T, Tezelman S. The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goiter. Arch Surg 2004;139:179-82.
  • 13. Grant CS, Hay ID, Gough IR, Bergstralh EJ, Goellner JR, McConahey WM. Local recurrence in papillary thyroid carcinoma: is extent of surgical resection important? Surgery 1988;104(6):954-6
  • 14. Reeve TS, Delbridge L, Brady P, Crummer P, Smyth C. Secondary thyroidectomy: a twenty-year experience. World J Surg 1988;12(4):449-53.
  • 15. Levin KE, Clark AH, Duh QY, Demeure M, Siperstein AE, Clark OH. Reoperative thyroid surgery. Surgery 1992;111(6):604-9.
  • 16. Pezzullo L, Delrio P, Losito NS, Caracò C, Mozzillo N. Post operation complications after completion thyroidectomy for differentiated thyroid cancer. Eur J Surg Oncol 1997;23(3):215-8.
  • 17. De Jong SA, Demeter JG, Lawrence AM, Paloyan E. Necessity and safety of completion thyroidectomy for differentiated thyroid carcinoma. Surgery 1992;112(4):734-7
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Umut Elboğa This is me

Ebuzer Kalender This is me

Avni Gökalp This is me

Suna Erkılıç This is me

Göktürk Maralcan This is me

Y. Zeki Çelen This is me

Mustafa Yılmaz This is me

Hasan Deniz Demir This is me

Hüseyin Karaoğlan This is me

Publication Date March 1, 2011
Published in Issue Year 2011 Volume: 17 Issue: 2

Cite

APA Elboğa, U., Kalender, E., Gökalp, A., Erkılıç, S., et al. (2011). Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz. Gaziantep Medical Journal, 17(2), 87-91.
AMA Elboğa U, Kalender E, Gökalp A, Erkılıç S, Maralcan G, Çelen YZ, Yılmaz M, Demir HD, Karaoğlan H. Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz. Gaziantep Medical Journal. March 2011;17(2):87-91.
Chicago Elboğa, Umut, Ebuzer Kalender, Avni Gökalp, Suna Erkılıç, Göktürk Maralcan, Y. Zeki Çelen, Mustafa Yılmaz, Hasan Deniz Demir, and Hüseyin Karaoğlan. “Tamamlayıcı Tiroidektomide Gamma Prob kullanımıyla Ilgili başlangıç Deneyimlerimiz”. Gaziantep Medical Journal 17, no. 2 (March 2011): 87-91.
EndNote Elboğa U, Kalender E, Gökalp A, Erkılıç S, Maralcan G, Çelen YZ, Yılmaz M, Demir HD, Karaoğlan H (March 1, 2011) Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz. Gaziantep Medical Journal 17 2 87–91.
IEEE U. Elboğa, E. Kalender, A. Gökalp, S. Erkılıç, G. Maralcan, Y. Z. Çelen, M. Yılmaz, H. D. Demir, and H. Karaoğlan, “Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz”, Gaziantep Medical Journal, vol. 17, no. 2, pp. 87–91, 2011.
ISNAD Elboğa, Umut et al. “Tamamlayıcı Tiroidektomide Gamma Prob kullanımıyla Ilgili başlangıç Deneyimlerimiz”. Gaziantep Medical Journal 17/2 (March 2011), 87-91.
JAMA Elboğa U, Kalender E, Gökalp A, Erkılıç S, Maralcan G, Çelen YZ, Yılmaz M, Demir HD, Karaoğlan H. Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz. Gaziantep Medical Journal. 2011;17:87–91.
MLA Elboğa, Umut et al. “Tamamlayıcı Tiroidektomide Gamma Prob kullanımıyla Ilgili başlangıç Deneyimlerimiz”. Gaziantep Medical Journal, vol. 17, no. 2, 2011, pp. 87-91.
Vancouver Elboğa U, Kalender E, Gökalp A, Erkılıç S, Maralcan G, Çelen YZ, Yılmaz M, Demir HD, Karaoğlan H. Tamamlayıcı tiroidektomide gamma prob kullanımıyla ilgili başlangıç deneyimlerimiz. Gaziantep Medical Journal. 2011;17(2):87-91.