Heterotopic bone formation in colorectal carcinoma: A case report

Year 2012, Volume: 18 Issue: 3, 180 - 182, 01.04.2012

Recep Bedir Hasan Güçer Remzi Adnan Akdoğan Ahmet Fikret Yücel

Abstract

Heterotopic bone formation (osseous metaplasia) is rarely seen in the gastrointestinal tract. It usually occurs in the colorectum in association with benign or malignant epithelial tumors, and most often with mucinous adenocarcinoma. The rectum is the most common location of ossification in the gastrointestinal tract. The pathogenesis of the heterotopic ossification is unknown, but it is probably the result of metaplasia of fibroblasts. We present a case of heterotopic bone formation in a primary rectal adenocarcinoma which was observed in a 73-year-old man.

Keywords

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Kolorektal karsinomda heterotopik kemik oluşumu: Olgu sunumu

Abstract

Heterotopik kemik oluşumu (kemik metaplazisi) gastrointestinal sistemde nadir olarak görülür. Genellikle kolorektal benign veya malign epitelyal tümörler ve sıklıkla müsinöz adenokarsinom ile birliktelik gösterir. Gastrointestinal sistemde rektum en sık tutulan bölgedir. Kemik metaplazisinin patogenezi bilinmemekte fakat fibroblastların metaplazisi sonucu oluştuğu düşünülmektedir. Yetmiş üç yaşında erkek hastada gözlenen primer kolorektal adenokarsinomda heterotopik kemik oluşumu irdelenmiştir.

Keywords

Adenokarsinom, kemik metaplazisi, kolon

References

• 1. Alper M, Akyürek N, Patiroğlu TE, Yüksel O, Belenli O. Heterotopic bone formation in two cases of colon carcinoma. Scand J Gastroenterol 2000;35(5):556-8
• 2. Haque S, Eisen RN, West AB. Heterotopic bone formation in the gastrointestinal tract. Arch Pathol Lab Med 1996;120(7):666-70
• 3. Ansari MQ, Sachs IL, Max E, Alpert LC. Heterotopic bone formation in rectal carcinoma. Case report and literature review. Dig Dis Sci 1992;37(10):1624-9
• 4. Pai SA, Bhasin SD, Krishnamurthy SC. Heterotopic ossification in colorectal adenocarcinoma. Indian J Pathol Microbiol 1993;36(3):304-7. (Erratum in Indian J Pathol Microbiol 1994;37(1):38
• 5. Dukes CE. Ossification in rectal cancer. Proc R Soc Med 1939;32(11):1489-94
• 6. Sampsel JW, Callaway F. Gastric carcinoid with ossification. Am J Surg 1972;124(1):108-11
• 7. Juvara I, Borcescu U. Heterotopic ossification of an appendicular mucocele. Br Med J 1948;1(4558):931-3
• 8. Apostolidis NS, Legakis NC, Gregoriadis GC, Androulakakis PA, Romanos AN. Heterotopic bone formation in abdominal operation scars. Report of six cases with review of the literature. Am J Surg 1981;142(5):555-9
• 9. Groisman GM, Benkov KJ, Adsay V, Dische MR. Osseous metaplasia in benign colorectal polyps. Arch Pathol Lab Med 1994;118(1):64-5
• 10. Oono Y, Fu KL, Nakamura H, Iriguchi Y, Oda J, Mizutani M, et al. Bone formation in a rectal inflammatory polyp. World J Gastrointest Endosc 2010;2(3):104-6
• 11. Randall JC, Morris DC, Tomita T, Anderson HC. Heterotopic ossification: a case report and immunohistochemical observations. Hum Pathol 1989;20(1):86-8
• 12. Anderson HC, Merker PC, Foch J. Formation of tumors containing bone after intramuscular injection of transformed human amnion cells (FL) into cortisone-treated mice. Am J Pathol 1964;44(3):507-19
• 13. Badmos KB, Seade LS, Faraj AA. Heterotopic ossification in a colorectal carcinoma. J Coll Physicians Surg Pak 2011;21(10):626-7
• 14. Jeong YJ, Lee MR, Kim JC, Hwang PH, Moon WS, Chung MJ. Carcinosarcoma of the rectosigmoid colon in a 13-year-old girl. Pathol Int 2008;58(7):445-50.