Deri ve deri eklerinin embriyolojik gelişimi

Öz

Embriyonik gelişimin üçüncü haftasında gastrulasyon ile üç germ tabakasından ektoderm, mezoderm ve endoderm oluşmaktadır. Nöral tüp oluşumuyla, yüzeyde kalan ektoderm, yüzey ektodermi şeklinde, epidermisin ve deri eklerinin epidermal türevleri olan kıl folikülleri, ter ve yağ bezleri, meme bezleri, tırnak oluşumundan sorumludur. Nöral tüpün kapanması ile birlikte oluşan krista nöralis hücreleri epidermise de göç etmekte, deri ve kıl yapılarında pigmentasyonu sağlayan melanositleri oluşturmaktadırlar. Merkel hücrelerinin embriyolojik kökeni ile ilgili olarak bazı araştırmacılar nöral krest kökenli olduğunu ileri sürerken, bazıları epidermal keratinositlerin differansiyasyonundan kaynaklandığını bildirmektedirler. Vücudun başlıca kompleks bir sistemi şeklinde çalışan deri ve ekleri embriyolojik gelişiminin ortaya konduğu bu derlemede literatür bilgileri değerlendirilmiştir.

Anahtar Kelimeler

• Deri, deri ekleri, embriyoloji

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