Merkel hücreli karsinom

Banu Taşkın

Merkel hücreli karsinom

Öz

ABSTRACT

Merkel-cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin. Incidence rates of MCC have increased in past decades. MCC presents as a firm red to livid tumor with a smooth, shiny surface. Satellite metastases can occur quite early but ulcerations are very rare. Light microscopy and immunohistochemical examination are used in the diagnosis of the tumor. Large local excision and sentinel lymph node biopsy is recommended for the treatment. Adjuvant radiotherapy reduces regional recurrence rates.

ÖZET

Merkel hücreli karsinom (MKH) nadir görülen, agresif seyirli, nöroendokrin bir deri tümörüdür. İnsidansı son dekatlarda artış göstermektedir. MHK sert, eritemli-viyolase, parlak yüzeyli nodül şeklinde ortaya çıkmaktadır. Kısa sürede satellit metastaz geliştirir ancak ülserasyon nadiren eşlik eder. Tanıda ışık mikroskopisi ve immunohistokimyasal incelemeler kullanılır. Tedavide geniş lokal eksizyon yapılması ve sentinel lenf nodu biyopsisi önerilmektedir. Adjuvan radyoterapi bölgesel rekürrens oranlarını azaltmaktadır.

Anahtar Kelimeler

skin cancer,diagnosis,surgical management,adjuvant radiotherapy,Merkel hücreli karsinom

References

1. Toker, C. Trabecular carcinoma of the skin. Arch. Dermatol 1972; 105, 107-10.
2. Allen PJ, Bowne WB, Jaques DP, et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol 2005; 23: 2300-9.
3. Girschik J, Thorn K, Beer TW, et al. Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival. Br J Dermatol 2011; 165: 1051-7.
4. Lebbe C, Becker JC, Grob JJ, et al. Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline. Eur J Cancer 2015; 51: 2396-403.
5. Heath M, Jaimes N, Lemos B, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol 2008; 58: 375-81.
6. Medina-Franco H, Urist MM, Fiveash J, et al. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol 2001; 8: 204-8.
7. Kuwamoto S. Recent advances in the biology of Merkel cell carcinoma. Hum Pathol 2011; 42: 1063-77.
8. Lemos BD, Storer BE, Iyer JG, et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 2010; 63: 751-61.

Details

Primary Language

Turkish

Subjects

-

Journal Section

Review

Authors

Banu Taşkın ^* This is me
İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, DERİ VE ZÜHREVİ HASTALIKLAR ANABİLİM DALI
Türkiye

Publication Date

December 24, 2017

Submission Date

November 20, 2017

Acceptance Date

December 24, 2017

Published in Issue

Year 2017 Volume: 2 Number: 3

IZ

https://izlik.org/JA38GW45MN

Cite

RIS / Bibtex

APA

Taşkın, B. (2017). Merkel hücreli karsinom. Güncel Dermatoloji Dergisi, 2(3), 69-71. https://izlik.org/JA38GW45MN

AMA

1.Taşkın B. Merkel hücreli karsinom. GDD. 2017;2(3):69-71. https://izlik.org/JA38GW45MN

Chicago

Taşkın, Banu. 2017. “Merkel Hücreli Karsinom”. Güncel Dermatoloji Dergisi 2 (3): 69-71. https://izlik.org/JA38GW45MN.

EndNote

Taşkın B (December 1, 2017) Merkel hücreli karsinom. Güncel Dermatoloji Dergisi 2 3 69–71.

IEEE

[1]B. Taşkın, “Merkel hücreli karsinom”, GDD, vol. 2, no. 3, pp. 69–71, Dec. 2017, [Online]. Available: https://izlik.org/JA38GW45MN

ISNAD

Taşkın, Banu. “Merkel Hücreli Karsinom”. Güncel Dermatoloji Dergisi 2/3 (December 1, 2017): 69-71. https://izlik.org/JA38GW45MN.

JAMA

1.Taşkın B. Merkel hücreli karsinom. GDD. 2017;2:69–71.

MLA

Taşkın, Banu. “Merkel Hücreli Karsinom”. Güncel Dermatoloji Dergisi, vol. 2, no. 3, Dec. 2017, pp. 69-71, https://izlik.org/JA38GW45MN.

Vancouver

1.Banu Taşkın. Merkel hücreli karsinom. GDD [Internet]. 2017 Dec. 1;2(3):69-71. Available from: https://izlik.org/JA38GW45MN