Kemiğin dev hücreli tümörü taklit eden primer hiperparatiroidizme bağlı brown tümörü

Öz

Primer hiperparatiroidizm (PHP) parathormon seviyelerinin yüksekliği ile karakterize endokrin bir hastalıktır. Hiperparatiroidizm komplikasyonlarından biri olan Brown tümörü, osteoklastik aktivite sonucu ortaya çıkar ve iskelet sisteminde lezyonlar, patolojik kırık ve ağrıya sebep olabilir. Brown tümörü hem histopatolojik hem de radyolojik incelemelerde primer kemik tümörü, anevrizmal kemik kisti veya kemiğin dev hücreli tümörü ile karışabilir. Bu sunumda metastatik kemik tümöründen şüphelenilen ancak primer hiperparatroidi tanısı alan 50 yaşında bayan hastanın sunumu yapılmaktadır. Brown tümörleri benign karakterli lezyonlardır ama malign kemik hastalıklarını taklit edebilirler. Hastalığın ayırıcı tanısında klinik, histopatolojik ve radyolojik bulguların birlikte değerlendirilmelidir.

Anahtar Kelimeler

• Hiperparatiroidizm,Brown tümörü

Brown tumor caused by primary hyperparathyroidism mimicking giant cell tumor of bone

Öz

Primary hyperparathyroidism (PHP) is an endocrine disorder characterized by the elevation of parathormone levels. Brown tumor, one of the complications of hyperparathyroidism, is the result of osteoclastic activity resulting in lesions, pathological fractures and pain in the skeletal system. Brown tumor can be confused with primary bone tumor, aneurysmal bone cyst or giant cell tumor of bone in both histopathological and radiological examinations. In this presentation, a 50-year-old female patient with a suspicion of metastatic bone tumor but diagnosed with primary hyperparathyroidism is presented. Brown tumors are benign lesions, but they can mimic malign bone diseases. Clinical, histopathologic and radiological findings should be evaluated together in differential diagnosis of the disease.

Anahtar Kelimeler

• Hyperparathyroidism,Brown tumor

Kaynakça

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