Is subclinical hypothyroidism increasing exogen obesity in children?

Yıl 2015, Cilt: 5 Sayı: 1, 1 - 7, 04.03.2015

Ceyda Kırsaçlıoğlu , Zeynep Şıklar Yıldız Dallar

https://doi.org/10.16899/ctd.57224

Öz

Background: We aimed to evaluate thyroid functions and subclinical hypothyroidism in obese children.

Methods: Fourty three children with exogenous obesity and 17 aged matched idiopathic short stature children (control group) were studied with anthropometric indices and basal thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), total thyroxine (TT4) and total triiodothyronine (TT3)  levels and they all underwent thyrotropin releasing hormone (TRH) stimulation test to determine TSH response.

Results: There were no significant difference in age, bone age, basal TSH, fT3, fT4, TT4 levels between obese and control group. Total triiodothyronine levels of obese group were significantly higher than control group (p=0.009). The maximum increment of TSH levels ( TSH)  and peak TSH levels in obese group were significantly lower than the control group (p=0.021, p=0.04 respectively). We evaluated obese children for TSH response and divided them into two groups; obese group 1 ( TSH response abnormally elevated) and obese group 2 (TSH response were normal), basal TSH levels of group 1 were found significantly higher than group 2 (p<0.001).

Conclusion: Thyrotropin releasing hormone stimulation test may be helpful to determine subclinical hypothyroidism in exogen obese children, if basal TSH levels were elevated.

Key words: 

Anahtar Kelimeler

Children, obesity, subclinical hypothyroidism, thyrotropin releasing hormone stimulation test

Subklinik Hipotroidi Çocuklarda Egzojen Obeziteyi Artırıyor mu?

Öz

Amaç: Obez çocuklarda tiroid fonksiyonları ve subklinik hipotroidi değerlendirilmesi amaçlandı.

Gereç ve yöntemler: Kırküç obez çocuk ve kontrol grubu olarak benzer yaştaki 17 idiopatik boy kısalığı olan çocuk, antropometrik ölçümler, bazal tiroid stimule edici hormon (TSH), serbest triiodotronin (sT3), serbest tiroksin (sT4), total tiroksin (TT4), total triiodotronin (TT3) düzeyleri ve tirotropin salgılatıcı hormon (TRH) uyarı testine TSH yanıtı ile değerlendirildi.

Sonuçlar: Obez ve kontrol grubunun, yaş, kemik yaşı, bazal TSH, sT3, sT4, TT4 düzeyleri arasında fark saptanmadı. Obez grubun TT3 düzeyleri kontrol grubundan anlamlı olarak yüksekti(p=0.009). TSH düzeylerinin maksimum artışı ve pik TSH düzeyleri, obez grupta, kontrol grubuna göre anlamlı olarak düşüktü (sırasıyla p=0.021, p=0.04). Obez grup, TSH yanıtına göre değerlendirildiğinde; Grup 1 (Anormal artış gösteren TSH yanıtı olanlar) ve grup 2 (TSH yanıtı normal olanlar) olarak ikiye ayrıldı. Grup 1'in bazal TSH’sı, grup 2'den anlamlı olarak yüksekti (p<0.001).

Karar: Bazal TSH düzeyleri yüksek olan obez çocuklarda TRH uyarı testi subklinik hipotroidizmi belirlemede yardımcı olabilir.

 

Anahtar Kelimeler

Çocuklar, obezite, subklinik hipotroidi, tirotropin salgılatıcı hormon uyarı testi

Kaynakça

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