An unusual organ involvement in a case of Werner Syndrome: thyroid atrophy

Year 2015, Volume: 5 Issue: 2, 144 - 146, 09.03.2015

Mustafa Altay , Mehmet Çölbay Füsun Törüner Müjde Aktürk Erkam Sencar Nuri Çakır Metin Arslan

https://doi.org/10.16899/ctd.41188

Abstract

Werner Syndrome (WS) is a premature aging disease that begins in adolescence or early adulthood and results in the appearance of old age by 30-40 years of age. Some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. In this article, we present a nineteen years-old female patient who had been diagnosed as WS two years ago because of type 2 diabetes mellitus, osteopenia, hyperlipidemia, cataract, gray hair, and skin atrophy. Subclinical hypothyroidism was detected at her laboratory tests. Thyroid ultrasonography (USG)  showed thyroid atrophy. Fine needle aspiration biopsy of both lobes  confirmed this diagnose and excluded some infiltrative diseases such as amyloidosis. It should be kept in mind that thyroid atrophy could be seen in WS and, therefore, detailed thyroid examination including thyroid USG and close follow up should be performed in all patients with WS.

 

Keywords

atrophy; thyroid; Werner syndrome

Werner Sendromlu bir olguda sıradışı organ tutulumu: tiroid atrofisi

Abstract

Werner Sendromu (WS) adölesan veya erken erişkin döneminde başlayan erken yaşlanmaya neden olan bir hastalıktır. Hastalar 30-40 yaşlarında yaşlı insan görünümündedirler. Bu nadir görülen hastalıkta, hipogonadizm, diabetes mellitus ve hiperlipidemi gibi bazı endokrinolojik anormallikler de olabilmektedir. Biz bu yazıda tip 2 diabetes mellitus, osteopeni, hiperlipidemi, katarakt, gri saç ve cilt atrofisi nedeniyle iki yıldır WS tanısı ile takip edilen 19 yaşında bir bayan hasta sunduk. Hastanın yapılan labotaruvar testlerinde subklinik hipotiroidi saptandı. Tiroid ultrasonografisinde (USG) tiroidin atrofik boyutlarda olduğu gözlendi. Her iki lobdan yapılan tiroid ince iğne aspirasyonu sonucu da atrofi ile uyumlu idi ve amiloidozis gibi bazı infiltratif hastalıklar dışlandı. WS’unda tiroid atrofisinin olabileceği akılda tutulmalıdır. Bu yüzden tüm WS’lu hastalarda tiroid USG’yi de içeren detaylı tiroid muayenesi yapılmalı ve bu açıdan yakın takip edilmelidir.

 

Keywords

atrofi; tiroid; Werner Sendromu

References

• Goto M. Werner's syndrome: from clinics to genetics. Clin Exp Rheumatol 2000;18(6):760-6.
• Goto M, Horiuchi Y, Tanimoto K, Ishii T, Nakashima H. Werner's syndrome: analysis of 15 cases with a review of the Japanese literature. J Am Geriatrics Soc 1978;26(8):341–7.
• Ostler EL, Wallis CV, Sheerin AN, Faragher RG. A model for the phenotypic presentation of Werner's syndrome. Exp Gerontol 2002;37(2-3):285-92.
• Ergün MA. [Replicative Ageing, Cellular Ageing and Apoptosis: Outcomes and Importance in Diseases]. Turkiye Klinikleri J Med Sci 2008;28(6 Suppl 1):S 21-6
• Martin GM, Sprauge CA, Epstein CJ. Replicative life-span of cultivated human cells. Effects of donor’s age, tissue, and genotype. Lab Invest 1970;23(1):86–92.
• Topaloğlu O, Çakır B, Aydın C, Ağaç T, Özkaba A. [Werner's Syndrome Presenting Without Hypogonadism: Differential Diagnosis]. Turkiye Klinikleri J Med Sci 2006;26(6):711-5.
• Zantour B, Messaoud R, Zouali M, Ladjimi A, Braham H, Hamza H, et al. Werner's syndrome and endocrine disorders. Ann Endocrinol 2003;64(3):205-9.
• Ishii T, Hosoda Y. Werner's syndrome: autopsy report of one case, with a review of pathologic findings reported in the literature. J Am Geriatr Soc 1975;23(4):145-54.
• Tokunaga M, Mori S, Sato K, Nakamura K, Wakamatsu E. Postmortem study of a case of Werner's syndrome. J Am Geriatr Soc 1976;24(9):407-11.
• Imura H, Nakao Y, Kuzuya H, Okamoto M, Okamoto M, Yamada K. Clinical, endocrine and metabolic aspects of the Werner syndrome compared with those of normal aging. Adv Exp Med Biol 1985;190:171-85.
• Ishikawa Y, Sugano H, Matsumoto T, Furuichi Y, Miller RW, Goto M. Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race. Cancer 1999;85(6):1345-52.