Abstract
Necrobiosis lipoidica diabeticorum (NLD) is an idiopathic cutaneous granulomatous dermatitis. The disease is usually seen in people with diabetes mellitus. The treatment of NLD is quite difficult and takes a long time, particularly in ulcerated forms. In this case, a girl with 10 years of age is presented with a persistent plaque which had been present for 2.5 years on her left shin. Local treatment with pimecrolimus (Elidel 1.0% cream) twice daily for one month, in addition to glucose control provided a progressive improvement of the lesion. So, pimecrolimus may be used safely and effectively in the treatment of NLD.
Key words: child; diabetes mellitus; necrobiosis lipoidica; pimecrolimus
References
- Pavlović MD, Milenković T, Dinić M et al. The prevalence of cutaneous manifestations in young patients with type 1 diabetes. Diabetes Care 2007;30 (8):1964-7.
- Ahmed I, Goldstein B. Diabetes mellitus. Clin Dermatol 2006;24 (4):237-46.
- Imakado S, Satomi H, Iskikawa M et al. Diffuse necrobiosis lipoidica diabeticorum associated with non-insulin dependent diabetes mellitus. Clin Exp Dermatol 1998;23(6): 271-3.
- Bonura C, Frontino G, Rigamonti A et al. Necrobiosis Lipoidica Diabeticorum: A pediatric case report. Dermatoendocrinol 2014;6 (1):e27790. doi: 10.4161/derm.27790
- Kavala M, Sudogan S, Zindanci I et al. Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine. Int J Dermatol 2010;49 (4):467-9.
- Narbutt J, Torzecka JD, Sysa-Jedrzejowska A,Zalewska A. Long-term results of topical PUVA in necrobiosis lipoidica. Clin Exp Dermatol 2006;31 (1):65-7.
- Gupta AK, Chow M. Pimecrolimus: a review. Journal of the European Academy of Dermatology and Venereology 2003;17 (5):493–503.
- Tyros G, Kalapothakou K, Christofidou E et al. Successful treatment of localized pemphigus foliaceus with topical pimecrolimus Case Rep Dermatol Med 2013;2013:489618. doi: 10.1155/2013/489618.
- Lee HW, Lee MW, Choi JH et al. Annular elastolytic giant cell granuloma in an infant: improvement after treatment with oral tranilast and topical pimecrolimus. J Am Acad Dermatol 2005;53 (5):244-6.
- Lübbe 1, Friedlander SF, Cribier B et al; NOBEL (New Online Based ELidel) Study Group. Safety, efficacy, and dosage of 1% pimecrolimus cream for the treatment of atopic dermatitis in daily practice. Am J Clin Dermatol 2006;7 (2):121-31.
Abstract
Nekrobiyozis lipoidika diyabetikorum (NLD), idiyopatik kutanöz granulamatöz bir dermatittir. Hastalık genellikle diyabetik popülasyonda görülür. NLD’nin tedavisi, özellikle ülsere formlarda, oldukça zordur ve uzun zaman alır. On yaşında kız çocuk, 2,5 yıldır sol bacağında olan inatçı bir plak ile başvurdu. Glikoz kontrolüne ek olarak bir ay boyunca günde iki kez lokal pimekrolimus (Elidel %1 krem) tedavisi ile lezyonda belirgin düzelme sağlandı. Sonuçta, pimekrolimus NLD tedavisinde güvenli ve etkili bir şekilde kullanılabilir.
References
- Pavlović MD, Milenković T, Dinić M et al. The prevalence of cutaneous manifestations in young patients with type 1 diabetes. Diabetes Care 2007;30 (8):1964-7.
- Ahmed I, Goldstein B. Diabetes mellitus. Clin Dermatol 2006;24 (4):237-46.
- Imakado S, Satomi H, Iskikawa M et al. Diffuse necrobiosis lipoidica diabeticorum associated with non-insulin dependent diabetes mellitus. Clin Exp Dermatol 1998;23(6): 271-3.
- Bonura C, Frontino G, Rigamonti A et al. Necrobiosis Lipoidica Diabeticorum: A pediatric case report. Dermatoendocrinol 2014;6 (1):e27790. doi: 10.4161/derm.27790
- Kavala M, Sudogan S, Zindanci I et al. Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine. Int J Dermatol 2010;49 (4):467-9.
- Narbutt J, Torzecka JD, Sysa-Jedrzejowska A,Zalewska A. Long-term results of topical PUVA in necrobiosis lipoidica. Clin Exp Dermatol 2006;31 (1):65-7.
- Gupta AK, Chow M. Pimecrolimus: a review. Journal of the European Academy of Dermatology and Venereology 2003;17 (5):493–503.
- Tyros G, Kalapothakou K, Christofidou E et al. Successful treatment of localized pemphigus foliaceus with topical pimecrolimus Case Rep Dermatol Med 2013;2013:489618. doi: 10.1155/2013/489618.
- Lee HW, Lee MW, Choi JH et al. Annular elastolytic giant cell granuloma in an infant: improvement after treatment with oral tranilast and topical pimecrolimus. J Am Acad Dermatol 2005;53 (5):244-6.
- Lübbe 1, Friedlander SF, Cribier B et al; NOBEL (New Online Based ELidel) Study Group. Safety, efficacy, and dosage of 1% pimecrolimus cream for the treatment of atopic dermatitis in daily practice. Am J Clin Dermatol 2006;7 (2):121-31.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | April 27, 2015 |
| Published in Issue | Year 2015 Volume: 5 Issue: 1-Ek |