DRACAENA CİNNABARİ REÇİNESİ VE TIBBİ OLARAK KULLANIMI

Yıl 2020, Cilt: 2 Sayı: 2, 16 - 21, 29.12.2020

Fadime Ovalı , Eissa Almaghrebi Fatma Akat , Hüsamettin Vatansev

Öz

Antik dünyanın çok değerli bir ürünü olan Dracaena cinnebari (DC) ağacı “Ejderha ağacı”, “Ejder Kanı Ağacı”, “İki Kardeşin Kanı” ve Arabistan’da da “dammalachawin” veya “cinnebar” olarak bilinmektedir. Ejderhanın kanı, antik çağlardan beri birçok kültür tarafından ünlü bir geleneksel tıp olarak kullanılan koyu kırmızı bir reçinedir. “Ejderhanın kanı” terimi, genellikle halk tıbbında kullanılan granüller, toz, topaklar veya çubuklar olarak karşılaşılan kırmızımsı reçineli ürünleri ifade eder. Ejderhanın kanı (Dracaena) Yemen halk tıbbında dizanteri, ishal, kanama ve dış ülser tedavisinde kullanılmaktadır. Dracaena reçinesi güçlü vazokonstrüktif özelliklere sahiptir ve kas gevşetici olarak kullanılır. Ayrıca gonore, idrarın durması, sulu gözler ve küçük yanıkların tedavisinde kullanılmıştır. Dracaena cinnabarini’nin ayrıca antikanser, antiviral, antimikrobiyal, antioksidan, antidiyabetik ve antifugal gibi önemli özelliklere sahiptir.

Anahtar Kelimeler

Dracaena cinnabari, Ejderha kanı, Yemen, Reçine

Kaynakça

• 1. Hubalkova I., Madera P, and Volarik D, Growth dynamics of Dracaena cinnabari under controlled conditions as the most effective way to protect endangered species. Saudi J Biol Sci, 2017. 24(7): p. 1445-1452.
• 2. Adolt Radim, J.P., Age structure and growth of Dracaena cinnabari populations on Socotra. Trees 2004. 18:43–53: p. 18:43–53.
• 3. Yahia S. Al-Awthan, M.A.Z., and Shtaywy Abdalla, Flavonoids Content of Dracaena cinnabari Resin and Effects of the Aqueous Extract on Isolated Smooth Muscle Preparations, Perfused Heart, Blood Pressure and Diuresis in the Rat. Jordan Journal of Pharmaceutical Sciences, 2010. Volume 3, No. 1, 2010 p. Volume 3, No. 1, 2010
• 4. Gupta, D., B. Bleakley, and R.K. Gupta, Dragon's blood: botany, chemistry and therapeutic uses. J Ethnopharmacol, 2008. 115(3): p. 361-80.
• 5. Khanum, Y.H.I.M.a.S.A., BIOLOGICAL EFFECT OF EXTRACTS DRACAEN CINNABARI BALF.F RESIN IN SOCOTRA ISLAND (YEMEN). J.Bio.Innov, 2015. 4(5),pp:216-235,2015.
• 6. Irena Hubálková, J.H., Jan Kubíček, Pavel Mazal, et al., PRELIMINARY ANATOMICAL STUDY ON SECONDARY THICKENING PARTS OF ENDEMIC DRACAENA CINNABARI BALF.FIL. FROM THE SOQOTRA ISLAND. WOOD RESEARCH, 2017. Vol. 62 (1): p. 67-78.
• 7. Abu-Taleb Ahmed Yehia, F.A.M.A., Tukaram Angadrao Kadam, Rafik Usman Shaikh, İn vitro evaluation of antimicrobial and antioxidant activity of Dragon’s blood tree (Dracaena cinnabari Balf.f.) of Socotra Island (Yemen) Journal of Coastal Life Medicine, 2013. 1(2): 123-129: p. 1(2): 123-129.
• 8. Mothana, R.A. and U. Lindequist, Antimicrobial activity of some medicinal plants of the island Soqotra. J Ethnopharmacol, 2005. 96(1-2): p. 177-81.
• 9. Mohammad Javed Ansari, A.A.-G., Noori Al-Waili, Nuru Adgaba, Khalid Ali Khan, Abdulraouf Amro, , ANTIMICROBIAL ACTIVITY OF DRACAENA CINNABARI RESIN FROM SOQOTRA ISLAND ON MULTI DRUG RESISTANT HUMAN PATHOGENS. Afr J Tradit Complement Altern Med. , 2016. 13(1):123-127: p. 13(1):123-127.
• 10. Mohamed Masaoud, K.H., Ahlam, H. Ahmed, and Maher. Ali. Al.Maqtar, LUPANE-TYPE TRITERPENOIDS DERIVATIVES FROM RESIN OF THE SOCOTRA DRAGON TREE (DRACAENA CINNABARI BALF., AGAVACEAE) World Journal of Pharmacy and Pharmaceutical Sciences, 2015. Volume 4, Issue 4, 182-194. : p. Volume 4, Issue 4, 182-194.
• 11. Cragg, G.M. and D.J. Newman, Antineoplastic agents from natural sources: achievements and future directions. Expert Opin Investig Drugs, 2000. 9(12): p. 2783-97.
• 12. R. A. A. Mothana, R.G.n., U. Lindequist, P. J. Bednarski, Study of the anticancer potential of Yemeni plants used in folk medicine. Pharmazie 2007. 62 (2007) 4: p. 62: 305–307 (2007).
• 13. Nair, S. and M.R. Pillai, Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Dis, 2005. 11(6): p. 350-9.
• 14. Beutler, J.A., Natural products as a foundation for drug discovery. Curr Protoc Pharmacol, 2009. Chapter 9: p. Unit 9 11.
• 15. Alabsi, A.M., et al., Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma. Biomed Res Int, 2016. 2016: p. 4904016.
• 16. Al-Afifi, N., et al., Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts. Clin Oral Investig, 2019. 23(5): p. 2287-2301.
• 17. Al-Fatimi, M., U. Friedrich, and K. Jenett-Siems, Cytotoxicity of plants used in traditional medicine in Yemen. Fitoterapia, 2005. 76(3-4): p. 355-8.
• 18. Mothana, R.A., et al., Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra. Phytother Res, 2006. 20(4): p. 298-302.
• 19. Machala, M., et al., Chemoprotective potentials of homoisoflavonoids and chalcones of Dracaena cinnabari: modulations of drug-metabolizing enzymes and antioxidant activity. Phytother Res, 2001. 15(2): p. 114-8.
• 20. Deepika Gupta, R.K.G., Bioprotective properties of Dragon’s blood resin: In vitro evaluation of antioxidant activity and antimicrobial activity. BMC Complementary and Alternative Medicine 2011. 11:13: p. 11:13.
• 21. Al-Fatimi, M., Ethnobotanical Survey of Dracaena cinnabari and Investigation of the Pharmacognostical Properties, Antifungal and Antioxidant Activity of Its Resin. Plants (Basel), 2018. 7(4).
• 22. Vesela, D., et al., Dracophane, a metacyclophane derivative from the resin of Dracaena cinnabari Balf. Phytochemistry, 2002. 61(8): p. 967-70.
• 23. Al-Afifi, N.A., et al., Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats. BMC Complement Altern Med, 2018. 18(1): p. 50.
• 24. Mohammed YHE, K.S., Anti-Diabetic Activity of Dracaen cinnabari Balf. f Extracts from Resin in Socotra Island-Yemen. Journal of Plant Biochemistry & Physiology, 2016.
• 25. Ratheesh M, H.A., Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats. African journal of Biotechnology, 2007: p. 6-10.