Effect of Additional Prebiotics on Glycemia and Lipid Profile in Individuals with Type 2 Diabetes

Abstract

This study was conducted to determine the effect of prebiotic fiber intake on glycemia and lipemia in individuals with Type 2 Diabetes Mellitus (Type 2 DM). Over a 8-week period, 14 individuals with Type 2 DM between the ages of 20-50 with a Body Mass Index (BMI) above 25 kg/m² were randomly assigned to either an intervention group, in which participants were given additional prebiotic fiber with diabetic diet (n = 8, consuming 10 g/d of oligofructose-enriched inulin to diabetic diet) or to a control group, in which participants were given only with a diabetic diet (n = 6, consuming only diabetic diet). Fasting Plasma Glucose (FPG), fasting insulin, insulin resistance (HOMA-IR), glycosylated hemoglobin (HbA1c), Triglyceride (TG), Total Cholesterol (Total-C), High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C) and Very Low-Density Lipoprotein Cholesterol (VLDL-C) values were measured at the beginning and end of the study. There was no significant difference between the initial and last measurements in HbA1c, fasting insulin, HOMA-IR, and HDL-C values only in the diabetic diet group (p>0.05); whereas FPG, TG, Total-C, LDL-C, and VLDL-C levels decreased (p<0.05). In the group that received additional prebiotics in the diet, the FPG, HbA1c, TG, Total-C, VLDL-C, and LDL-C levels decreased significantly (p<0.05) at the end of the study compared to the beginning; HDL-C (p<0.05) was elevated. Prebiotics can be used as a new option in the treatment of many metabolic diseases, especially diabetes. Prebiotics will make a positive contribution to metabolic markers by changing the composition of the microbiota.

Keywords

• gycemic control
• lipemia
• prebiotic
• Type 2 diabetes

References

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