Review

Carbohydrate-Insulin Model In Obesity- An Updated Review

Volume: 7 Number: 2 September 29, 2025
EN

Carbohydrate-Insulin Model In Obesity- An Updated Review

Abstract

The prevalence of obesity is increasing rapidly worldwide and represents a serious public health problem. In order to prevent obesity, the causes of obesity should be identified and appropriate interventions developed. In this review, the carbohydrate-insulin model, which is one of the causal perspectives to obesity, and recent studies on this approach are discussed and evaluated together with the energy balance model. Reduced total energy expenditure when adhering to healthy dietary recommendations without energy restriction or dietary energy restriction interventions makes it difficult to understand the energy-independent insulinemic effect of diet. Although more studies are needed on the causal approaches to obesity, it was concluded that high-fibre and low-glycaemic load diets, rather than carbohydrate-restricted diets in the carbohydrate-insulin model, may give more favorable results in trials. In addition, individualized nutritional and dietary models should be developed under the guidance of a dietician in the treatment of obesity.

Keywords

Supporting Institution

No funding was received for this study.

References

  1. Aas, A, M., Axelsen, M., Churuangsuk, C., Hermansen, K., Kendall, C. W. C., Kahleova, H., Khan, T., Lean, M. E. J., Mann, J. I., Pedersen, E., Pfeiffer, A., Rahelić, D., Reynolds, A. N., Risérus, U., Rivellese, A. A., Salas-Salvadó, J., Schwab, U., Sievenpiper, J. L., Thanopoulou, A., & Nutrition Study Group of the European Association for the Study of Diabetes. (2023). Evidence-based European recommendations for the dietary management of diabetes. Diabetologia, 66(6), 965-985. https://doi.org/10.1007/s00125-023-05894-8
  2. Barber, T. M., Hanson, P., Kabisch, S., Pfeiffer, A. F., & Weickert, M. O. (2021). The low-carbohydrate diet: Short-term metabolic efficacy versus longer-term limitations. Nutrients, 13(4), 1187. https://doi.org/10.3390/nu13041187
  3. Bazzano, L. A., Hu, T., Reynolds, K., Yao, L., Bunol, C., Liu, Y., Chen, C.-S., Klag, M. J., Whelton, P. K., & He, J. (2014). Effects of low-carbohydrate and low-fat diets: A randomized trial. Annals of Internal Medicine, 161(5), 309-318. https://doi.org/10.7326/M14-0180
  4. Bueno, N. B., de Melo, I. S., de Oliveira, S. L., & da Rocha Ataide, T. (2013). Very-low-carbohydrate ketogenic diet vs. low-fat diet for long-term weight loss: A meta-analysis of randomized controlled trials. British Journal of Nutrition, 110(7), 1178-1187. https://doi.org/10.1017/s0007114513000548
  5. Cronin, P., Joyce, S. A., O'Toole, P. W., & O'Connor, E. M. (2021). Dietary fibre modulates the gut microbiota. Nutrients, 13(5), 1655. https://doi.org/10.3390/nu13051655
  6. Chen, R., & Chen, G. (2022). Personalized nutrition for people with diabetes and at risk of diabetes has begun. Journal of Future Foods, 2(3), 193-202.
  7. Dorans, K. S., Bazzano, L. A., Qi, L., He, H., Chen, J., Appel, L. J., Chen, C.-S., Hsieh, M.-H., Hu, F. B., & Mills, K. T. (2022). Effects of a low-carbohydrate dietary intervention on hemoglobin A1c: A randomized clinical trial. JAMA Network Open, 5(10), e2238645-e2238645. https://doi.org/10.1001/jamanetworkopen.2022.38645
  8. Ebrahimpour-Koujan, S., Keshteli, A. H., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2019). Adherence to low carbohydrate diet and prevalence of psychological disorders in adults. Journal of Nutrition, 18(1):87.https://doi.org/10.1186/s12937-019-0513-8

Details

Primary Language

English

Subjects

Health Services and Systems (Other)

Journal Section

Review

Publication Date

September 29, 2025

Submission Date

December 2, 2024

Acceptance Date

May 6, 2025

Published in Issue

Year 2025 Volume: 7 Number: 2

APA
Akyakar, B., & Akdevelioğlu, Y. (2025). Carbohydrate-Insulin Model In Obesity- An Updated Review. Journal of Gazi University Health Sciences Institute, 7(2), 37-45. https://doi.org/10.59124/guhes.1595201
AMA
1.Akyakar B, Akdevelioğlu Y. Carbohydrate-Insulin Model In Obesity- An Updated Review. GUHES. 2025;7(2):37-45. doi:10.59124/guhes.1595201
Chicago
Akyakar, Buket, and Yasemin Akdevelioğlu. 2025. “Carbohydrate-Insulin Model In Obesity- An Updated Review”. Journal of Gazi University Health Sciences Institute 7 (2): 37-45. https://doi.org/10.59124/guhes.1595201.
EndNote
Akyakar B, Akdevelioğlu Y (September 1, 2025) Carbohydrate-Insulin Model In Obesity- An Updated Review. Journal of Gazi University Health Sciences Institute 7 2 37–45.
IEEE
[1]B. Akyakar and Y. Akdevelioğlu, “Carbohydrate-Insulin Model In Obesity- An Updated Review”, GUHES, vol. 7, no. 2, pp. 37–45, Sept. 2025, doi: 10.59124/guhes.1595201.
ISNAD
Akyakar, Buket - Akdevelioğlu, Yasemin. “Carbohydrate-Insulin Model In Obesity- An Updated Review”. Journal of Gazi University Health Sciences Institute 7/2 (September 1, 2025): 37-45. https://doi.org/10.59124/guhes.1595201.
JAMA
1.Akyakar B, Akdevelioğlu Y. Carbohydrate-Insulin Model In Obesity- An Updated Review. GUHES. 2025;7:37–45.
MLA
Akyakar, Buket, and Yasemin Akdevelioğlu. “Carbohydrate-Insulin Model In Obesity- An Updated Review”. Journal of Gazi University Health Sciences Institute, vol. 7, no. 2, Sept. 2025, pp. 37-45, doi:10.59124/guhes.1595201.
Vancouver
1.Buket Akyakar, Yasemin Akdevelioğlu. Carbohydrate-Insulin Model In Obesity- An Updated Review. GUHES. 2025 Sep. 1;7(2):37-45. doi:10.59124/guhes.1595201