Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study

Ayşe Derya Bayazit; Rümeysa Kan; Büşra Nur Sağcan; Fatma Nur Karabulut; Yasemin Akdevelioğlu

doi:10.59124/guhes.1920153

Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study

Abstract

TThis study aimed to assess dietary inflammatory potential and total dietary antioxidant capacity (TDAC) in women with polycystic ovary syndrome (PCOS) and to examine their associations with body composition compared with non-PCOS group. This case–control study included 57 women (mean age 22.4 ± 1.44 years), comprising 28 women with PCOS and 29 the non-PCOS women. Anthropometric measurements and body composition were assessed using standard procedures. The Dietary Inflammatory Index (DII) and TDAC were calculated based on diet. Waist circumference, hip circumference, and body fat percentage were significantly higher in the PCOS group than in the non-PCOS group (p < 0.05). Median DII values were -2.5 (-8.9 to -1.5) in the PCOS group and -4.5 (-8.5 to -1.5) in the non-PCOS group, with no statistically significant difference between the groups (p > 0.05), whereas TDAC was significantly lower in the women with PCOS whose TDAC score was 5.1 mmol/day (3.9 to 7.6) compared to the non-PCOS women whose TDAC score was 7.5 mmol/day (5.1 to 13.5) (p = 0.019). In the PCOS group, TDAC was positively correlated with total body water percentage (r = 0.487, p = 0.009) and negatively correlated with bone mass (r = −0.489, p = 0.008). In the non-PCOS group, DII showed a strong positive correlation with hip circumference (r = 0.637, p < 0.001). These findings suggest that women with PCOS have lower dietary antioxidant capacity, which may be associated with alterations in body composition. Additionally, pro-inflammatory dietary patterns may be linked to fat distribution even in healthy individuals. Nutritional strategies in PCOS management should, therefore, emphasize improving dietary antioxidant quality alongside energy balance.

Keywords

Ethical Statement

This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Gazi University Non-Interventional Clinical Research Ethics Committee (Approval No: 2025-857; Date: May 13, 2025). Written informed consent was obtained from all participants prior to their inclusion in the study.

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Details

Primary Language

English

Subjects

Primary Health Care

Journal Section

Research Article

Authors

Ayşe Derya Bayazit ^*
0000-0003-1361-9569
Türkiye

Rümeysa Kan
0009-0001-8144-8717
Türkiye

Büşra Nur Sağcan
0009-0003-8537-6524
Türkiye

Fatma Nur Karabulut
0009-0002-6087-9611
Türkiye

Yasemin Akdevelioğlu
0000-0002-2213-4419
Türkiye

Publication Date

April 30, 2026

Submission Date

April 1, 2026

Acceptance Date

April 25, 2026

Published in Issue

Year 2026 Volume: 8 Number: 1

DOI

https://doi.org/10.59124/guhes.1920153

IZ

https://izlik.org/JA57RM24GN

Cite

RIS / Bibtex

APA

Bayazit, A. D., Kan, R., Sağcan, B. N., Karabulut, F. N., & Akdevelioğlu, Y. (2026). Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study. Journal of Gazi University Health Sciences Institute, 8(1), 45-56. https://doi.org/10.59124/guhes.1920153

AMA

1.Bayazit AD, Kan R, Sağcan BN, Karabulut FN, Akdevelioğlu Y. Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study. GUHES. 2026;8(1):45-56. doi:10.59124/guhes.1920153

Chicago

Bayazit, Ayşe Derya, Rümeysa Kan, Büşra Nur Sağcan, Fatma Nur Karabulut, and Yasemin Akdevelioğlu. 2026. “Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women With Polycystic Ovary Syndrome: A Case–Control Study”. Journal of Gazi University Health Sciences Institute 8 (1): 45-56. https://doi.org/10.59124/guhes.1920153.

EndNote

Bayazit AD, Kan R, Sağcan BN, Karabulut FN, Akdevelioğlu Y (April 1, 2026) Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study. Journal of Gazi University Health Sciences Institute 8 1 45–56.

IEEE

[1]A. D. Bayazit, R. Kan, B. N. Sağcan, F. N. Karabulut, and Y. Akdevelioğlu, “Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study”, GUHES, vol. 8, no. 1, pp. 45–56, Apr. 2026, doi: 10.59124/guhes.1920153.

ISNAD

Bayazit, Ayşe Derya - Kan, Rümeysa - Sağcan, Büşra Nur - Karabulut, Fatma Nur - Akdevelioğlu, Yasemin. “Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women With Polycystic Ovary Syndrome: A Case–Control Study”. Journal of Gazi University Health Sciences Institute 8/1 (April 1, 2026): 45-56. https://doi.org/10.59124/guhes.1920153.

JAMA

1.Bayazit AD, Kan R, Sağcan BN, Karabulut FN, Akdevelioğlu Y. Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study. GUHES. 2026;8:45–56.

MLA

Bayazit, Ayşe Derya, et al. “Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women With Polycystic Ovary Syndrome: A Case–Control Study”. Journal of Gazi University Health Sciences Institute, vol. 8, no. 1, Apr. 2026, pp. 45-56, doi:10.59124/guhes.1920153.

Vancouver

1.Ayşe Derya Bayazit, Rümeysa Kan, Büşra Nur Sağcan, Fatma Nur Karabulut, Yasemin Akdevelioğlu. Assessment of Dietary Inflammatory Index and Antioxidant Capacity in Women with Polycystic Ovary Syndrome: A Case–Control Study. GUHES. 2026 Apr. 1;8(1):45-56. doi:10.59124/guhes.1920153