From Probiotics to Psychobiotics: A Focused Review

Abstract

Our microbiome consists of trillions of microorganisms. Probiotics are known to be favorable microorganisms (bacteria and yeast) to keep the gut healthy and other health effects. They have been shown to possess positive effects not only in digestion, but also on heart, brain, etc. Lately, many studies pointed out to promoting activities of probiotics in mental diseases through gut microbiota, which is so-called “psychobiome”. It is now clear that bacterial inhabitants of the intestines may impact neurons and the brain through some mechanisms. Consequently, psychobiotics have been described as a new class of probiotics. In the current mini review, the role of psychobiotics is scrutinized focusing on some neurological and mental diseases.

Keywords

• gut
• menthal health
• Microbiota
• Probiotics
• Psychobiotics

References

1. Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., ... & Clarke, G. (2016). Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Translational Psychiatry, 6(11), e939. doi: 10.1038/tp.2016.191.
2. Arnold, L. E. (2018). Probiotics for Quality of Life in Autism Spectrum Disorders. ClinicalTrials.gov Identifier: NCT02903030. https://clinicaltrials.gov/ct2/show/NCT02903030.
3. Athari Nik Azm, S., Djazayeri, A., Safa, M., Azami, K., Ahmadvand, B., Sabbaghziarani, F., ... & Vafa, M. (2018). Lactobacilli and Bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1-42) injected rats. Applied Physiology Nutrition and Metabolism, 43(7), 718. doi: 10.1139/apnm-2017-0648.
4. Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012). γ-Aminobutyric acid production by culturable bacteria from the human intestine. Journal of Applied Microbiology, 113(2), 411. doi: 10.1111/j.1365-2672.2012.05344.x.
5. Bercik, P., Verdu, E. F., Foster, J. A., Macri, J., Potter, M., Huang, X., ... & Lu, J. (2010). Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology, 139(6), 2102. doi: 10.1053/j.gastro.2010.06.063.
6. Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Berardi, S., Scarpona, S., ... & Eleuteri, A. M. (2018). SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model. Molecular Neurobiology, 55(10), 7987. doi: 10.1007/s12035-018-0973-4.
7. Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., ... & Cryan, J. F. (2011). Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences, 108(38), 16050. https://doi.org/10.1073/pnas.1102999108.
8. Cani, P., Everard, A., & Duparc, T. (2013). Gut microbiota, enteroendocrine functions and metabolism. Current Opinion in Pharmacology, 13(6), 935. doi: 10.1016/j.coph.2013.09.008.

9. Cassani, E., Privitera, G., Pezzoli, G., Pusani, C., Madio, C., Iorio, L., & Barichella, M. (2011). Use of probiotics for the treatment of constipation in Parkinson's disease patients. Minerva Gastroenterologica e Dietologica, 57(2), 117. PMID: 21587143.
10. Cheng, L. H., Liu, Y. W., Wu, C. C., Wang, S., & Tsai, Y. C. (2019). Psychobiotics in mental health, neurodegenerative, and neurodevelopmental disorders. Journal of Food and Drug Analysis, 27(3), 632. doi: 10.1016/j.jfda.2019.01.002.
11. De Rijk, M. D., Tzourio, C., Breteler, M. M., Dartigues, J. F., Amaducci, L., Lopez-Pousa, S., ... & Rocca, W. D. (1997). Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's Disease. Journal of Neurology Neurosurgery & Psychiatry, 62(1), 10. doi: 10.1136/jnnp.62.1.10.
12. Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010). Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience, 170(4), 1179. doi: 10.1016/j.neuroscience.2010.08.005.
13. Dinan, T. G., Stanton, C., & Cryan, J. F. (2013). Psychobiotics: a novel class of psychotropic. Biological Psychiatry, 74(10), 720. doi: 10.1016/j.biopsych.2013.05.001.
14. Erbay-Gönenir, L., & Seçkin, Y. (2016). Yeme bozuklukları. Güncel Gastroenteroloji, 20(4), 473.
15. Evrensel, A., & Ceylan, M. E. (2015). Bağırsak beyin ekseni: psikiyatrik bozukluklarda bağırsak mikrobiyotasının rolü. Psikiyatride Güncel Yaklaşımlar-Current Approaches in Psychiatry, 7(4), 461. doi: 10.5455/cap.20150128123852.
16. Grundgeiger, T., Bayen, U. J., & Horn, S. S. (2014). Effects of sleep deprivation on prospective memory. Memory, 22(6), 679. doi: 10.1080/09658211.2013.812220.
17. Harding, K. L., Judah, R. D., & Gant, C. E. (2003). Outcome-based comparison of Ritalin® versus food-supplement treated children with AD/HD. Alternative Medicine Review, 8(3), 319. PMID: 12946241.
18. Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007). Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Molecular Psychiatry, 12(7), 656. doi: 10.1038/sj.mp.4001957.
19. Huang, R., Wang, K., & Hu, J. (2016). Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials. Nutrients, 8(8), 483. doi: 10.3390/nu8080483.
20. Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., … & Ruan, B. (2015). Altered fecal microbiota composition in patients with major depressive disorder. Brain Behavior and Immunity, 48, 186. doi: 10.1016/j.bbi.2015.03.016.
21. Kaneita, Y., Ohida, T., Uchiyama, M., Takemura, S., Kawahara, K., Yokoyama, E., ... & Fujita, T. (2006). The relationship between depression and sleep disturbances: a Japanese nationwide general population survey. The Journal of Clinical Psychiatry, 67(2), 196. doi: 10.4088/jcp.v67n0204.
22. Kang, D. W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013). Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PloS one, 8(7), e68322. doi: 10.1371/journal.pone.0068322.
23. Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., … & Dinan, T. G. (2016). Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatry Research, 82, 109. doi: 10.1016/j.jpsychires.2016.07.019.
24. Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., ... & Shannon, K. M. (2015). Colonic bacterial composition in Parkinson's disease. Movement Disorders, 30(10), 1351. doi: 10.1002/mds.26307.
25. Kumar, A., & Singh, A. (2015). A review on Alzheimer's disease pathophysiology and its management: an update. Pharmacological Reports, 67(2), 195-203. doi: 10.1016/j.pharep.2014.09.004.
26. Leblhuber, F., Steiner, K., Schuetz, B., Fuchs, D., & Gostner, J. M. (2018). Probiotic supplementation in patients with Alzheimer's dementia - an explorative intervention study. Current Alzheimer Research, 15(12), 1106. doi: 10.2174/1389200219666180813144834.
27. Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018). The role of microbiome in insomnia, circadian disturbance and depression. Frontiers in Psychiatry, 9, 669. doi: 10.3389/fpsyt.2018.00669.
28. Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., ... & Jin, F. (2015). Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience, 310, 561. doi: 10.1016/j.neuroscience.2015.09.033.
29. Liu, Y. W., Liu, W. H., Wu, C. C., Juan, Y. C., Wu, Y. C., Tsai, H. P., ... & Tsai, Y. C. (2016). Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Research, 1631, 1. doi: 10.1016/j.brainres.2015.11.018.
30. Liu, W. H., Yang, C. H., Lin, C. T., Li, S. W., Cheng, W. S., Jiang, Y. P., ... & Tsai, Y. C. (2015). Genome architecture of Lactobacillus plantarum PS128, a probiotic strain with potential immunomodulatory activity. Gut Pathogens, 7(1), 1. doi: 10.1186/s13099-015-0068-y.
31. Lu, Y., Christian, K., & Lu, B. (2008). BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiology of Learning and Memory, 89(3), 312. doi: 10.1016/j.nlm.2007.08.018.
32. Mangiola, F., Ianiro, G, Franceschi, F., Fagiuoli, S., Gasbarrini, G., & Gasbarrini, A. (2016). Gut microbiota in autism and mood disorders. World Journal of Gastroenterology, 22(1), 361. doi: 10.3748/wjg.v22.i1.361.
33. Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., ... & Cazaubiel, J. M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755. doi: 10.1017/S0007114510004319.
34. Miyazaki, K., Itoh, N., Yamamoto, S., Higo-Yamamoto, S., Nakakita, Y., Kaneda, H., ... & Oishi, K. (2014). Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice. Life sciences, 111(1-2), 47. doi: 10.1016/j.lfs.2014.07.009.
35. Mohammadi, A. A., Jazayeri, S., Khosravi-Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., ... & Eghtesadi, S. (2016). The effects of probiotics on mental health and hypothalamic-pituitary-adrenal axis: a randomized, double-blind, placebo-controlled trial in petrochemical workers. Nutritional Neuroscience, 19(9), 387. doi: 10.1179/1476830515Y.0000000023.
36. Murphy, T. K., Lewin, A. B., Storch, E. A., & Stock, S. (2013). Practice parameter for the assessment and treatment of children and adolescents with tic disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 52(12), 1341. doi: 10.1016/j.jaac.2013.09.015.
37. Nakakita, Y., Tsuchimoto, N., Takata, Y., & Nakamura, T. (2016). Effect of dietary heat-killed Lactobacillus brevis SBC8803 (SBL88™) on sleep: a non-randomized, double blind, placebo-controlled, and crossover pilot study. Beneficial Microbes, 7(4), 501. doi: 10.3920/BM2015.0118.
38. O'Mahony, L., Mccarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., … & Quigley, E. M. M. (2005). Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology, 128(3), 541. doi: 10.1053/j.gastro.2004.11.050.
39. Parracho, H. M., Gibson, G. R., Knott, F., Bosscher, D., Kleerebezem, M., & McCartney, A. L. (2010). A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders. International Journal of Probiotics & Prebiotics, 5(2), 69. (doi not available)
40. Pärtty, A., Kalliomäki, M., Wacklin, P., Salminen, S., & Isolauri, E. (2015). A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatric Research, 77(6), 823. doi: 10.1038/pr.2015.51.
41. Philips, J. G. P. (1910). The treatment of melancholia by the lactic acid bacillus. Journal of Mental Science, 56(234), 422. (doi not available)
42. Rampello, L., Alvano, A., Battaglia, G., Bruno, V., Raffaele, R., & Nicoletti, F. (2006). Tic disorders: from pathophysiology to treatment. Journal of Neurology, 253(1), 1. doi: 10.1007/s00415-005-0008-8.
43. Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, C. F., Burnet, P. W. J. (2016). Psychobiotics and the manipulation of bacteria-gut-brain signals. Trends in Neurosciences, 39(11), 763. doi: 10.1016/j.tins.2016.09.002.
44. Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014). Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterology & Motility, 26(11), 1615. doi: 10.1111/nmo.12427.
45. Schousboe, A., & Waagepetersen, H. S. (2007). GABA: homeostatic and pharmacological aspects. Progress in Brain Research, 160, 9. doi: 10.1016/S0079-6123(06)60002-2.
46. Shaaban, S. Y., El Gendy, Y. G., Mehanna, N. S., El-Senousy, W. M., El-Feki, H. S., Saad, K., & El-Asheer, O. M. (2018). The role of probiotics in children with autism spectrum disorder: a prospective, open-label study. Nutritional Neuroscience, 21(9), 676. doi: 10.1080/1028415X.2017.1347746.
47. Shults, C. W. (2006). Lewy bodies. Proceedings of the National Academy of Sciences, 103(6), 1661. doi: 10.1073/pnas.0509567103.
48. Sucksdorff, M., Lehtonen, L., Chudal, R., Suominen, A., Joelsson, P., Gissler, M., & Sourander, A. (2015). Preterm birth and poor fetal growth as risk factors of attention-deficit/hyperactivity disorder. Pediatrics, 136(3), e599. doi: 10.1542/peds.2015-1043.
49. Tamam, L., & Zeren, T. (2002). Depresyonda serotonerjik düzenekler. Klinik Pskiyatri Dergisi, 5(4), 11. (doi not available)
50. Tamtaji, O. R., Taghizadeh, M., Kakhaki, R. D., Kouchaki, E., Bahmani, F., Borzabadi, S., ... & Asemi, Z. (2019). Clinical and metabolic response to probiotic administration in people with Parkinson's disease: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 38(3), 1031. doi: 10.1016/j.clnu.2018.05.018.
51. Tang, F., Reddy, B., & Saier, M. (2014). Psychobiotics and their involvement in mental health. Journal of Molecular Microbiology and Biotechnology, 24, 211. doi: 10.1159/000366281.
52. Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., ... & Bendlin, B. B. (2017). Gut microbiome alterations in Alzheimer’s disease. Scientific Reports, 7(1), 1. doi: 10.1038/s41598-017-13601-y.
53. Wallace, C. J., & Milev, R. (2017). The effects of probiotics on depressive symptoms in humans: a systematic review. Annals of General Psychiatry, 16(1), 14. doi: 10.1186/s12991-017-0138-2.
54. Wang, X., Wang, B. R., Zhang, X. J., Xu, Z., Ding, Y. Q., Ju, G. (2002). Evidences for vagus nerve in maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats. World Journal of Gastroenterology, 8(3), 540. doi: 10.3748/wjg.v8.i3.540.
55. Weisman, H., Qureshi, I. A., Leckman, J. F., Scahill, L., & Bloch, M. H. (2013). Systematic review: pharmacological treatment of tic disorders-efficacy of antipsychotic and alpha-2 adrenergic agonist agents. Neuroscience & Biobehavioral Reviews, 37(6), 1162. doi: 10.1016/j.neubiorev.2012.09.008.
56. Yamamura, S., Morishima, H., Kumano-go, T., Suganuma, N., Matsumoto, H., Adachi, H., ... & Takano, T. (2009). The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects. European Journal of Clinical Nutrition, 63(1), 100. doi: 10.1038/sj.ejcn.1602898.
57. Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., ... & Hsiao, E. Y. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 161(2), 264. doi: 10.1016/j.cell.2015.02.047.
58. Zhao, H., Shi, Y., Luo, X., Peng, L., Yang, Y., & Zou, L. (2017). The effect of fecal microbiota transplantation on a child with Tourette syndrome. Case reports in Medicine, 2017. doi: 10.1155/2017/6165239.