Female Infertility and the Mediterranean Diet

Year 2022, Volume: 4 Issue: 2, 96 - 106, 31.08.2022

Özge Cemali , Yasemin Akdevelioğlu

Abstract

The World Health Organization defines infertility, which affects 80 million women worldwide, as the absence of clinical pregnancy after a year of unprotected and frequent sexual activity. Other variables that affect female infertility include environmental factors, lifestyle choices, and diseases that affect the pathophysiology of the reproductive organs. The impact of alternative therapies is growing in order to support environmental and lifestyle impacts and improve the likelihood of clinical pregnancy in infertile couples. Among alternative treatments, lifestyle modifications including exercise and dietary changes are most prominent. There is currently no essential nutrient or diet for optimizing reproductive health. One of the most extensively studied topics in infertility as well as in many other health issues is the Mediterranean diet. The Mediterranean diet is known for its high intake of fruits, vegetables, whole grains, legumes, oilseeds, and olives as well as its moderate consumption of milk, dairy products, and fish. Olive oil is preferred as the main source of dietary fat in the diet. The diet allows for modest wine consumption as well as less red meat and poultry. The Mediterranean diet's potential impacts on female reproductive health are discussed in this review due to its great nutritional diversity, which includes bioactive ingredients, fiber, and poly- and monounsaturated fatty acids.

Keywords

Mediterranean Diet, Reproductive Health, Female Infertility

References

• Ainamo, J., & Bay, I. (1975). Problems and proposals for recording gingivitis and plaque. International Dental Journal, 25(4),229-235.
• Adlercreutz, H. (2007). Lignans and human health. Critical Reviews in Clinical Laboratory Sciences, 44(5-6), 483-525.
• Arnoldussen, I. A., & Kiliaan, A. J. (2014). Impact of DHA on metabolic diseases from womb to tomb. Marine Drugs, 12(12), 6190-6212.
• Bach-Faig, A., Berry, E. M., Lairon, D., Reguant, J., Trichopoulou, A., Dernini, S., ... & Serra-Majem, L. (2011). Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutrition, 14(12A), 2274-2284.
• Baker, J. M., Al-Nakkash, L., & Herbst-Kralovetz, M. M. (2017). Estrogen–gut microbiome axis: physiological and clinical implications. Maturitas, 103, 45-53.
• Banwo, K., Olojede, A. O., Adesulu-Dahunsi, A. T., Verma, D. K., Thakur, M., Tripathy, S., ... & Utama, G. L. (2021). Functional importance of bioactive compounds of foods with Potential Health Benefits: A review on recent trends. Food Bioscience, 43, 101320.
• Chiu, Y. H., Karmon, A. E., Gaskins, A. J., Arvizu, M., Williams, P. L., Souter, I., ... & EARTH Study Team. (2018). Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Human Reproduction, 33(1), 156-165.
• Comerford, K. B., Ayoob, K. T., Murray, R. D., & Atkinson, S. A. (2016). The role of avocados in maternal diets during the periconceptional period, pregnancy, and lactation. Nutrients, 8(5), 313.
• Fayezi, S., Leroy, J. L., Novin, M. G.,&Darabi, M. (2018). Oleic acid in the modulation of oocyte and preimplantation embryo development.Zygote,26(1),1-13.
• Ferroni, P., Barbanti, P., Della-Morte, D., Palmirotta, R., Jirillo, E., & Guadagni, F. (2018). Redox mechanisms in migraine: novel therapeutics and dietary interventions. Antioxidants & Redox Signaling, 28(12), 1144-1183.
• Fontana, R., & Della Torre, S. (2016). The deep correlation between energy metabolism and reproduction: a view on the effects of nutrition for women fertility. Nutrients, 8(2), 87.
• Hammiche, F., Vujkovic, M., Wijburg, W., de Vries, J. H., Macklon, N. S., Laven, J. S., & Steegers-Theunissen, R. P. (2011). Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology. Fertility and Sterility, 95(5), 1820-1823.
• Jungheim, E. S., Macones, G. A., Odem, R. R., Patterson, B. W., Lanzendorf, S. E., Ratts, V. S., & Moley, K. H. (2011). Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertility and sterility, 95(6), 1970-1974.
• Jungheim, E. S., Frolova, A. I., Jiang, H., & Riley, J. K. (2013). Relationship between serum polyunsaturated fatty acids and pregnancy in women undergoing in vitro fertilization. The Journal of Clinical Endocrinology & Metabolism, 98(8), E1364-E1368.
• Jahangirifar, M., Taebi, M., Nasr-Esfahani, M. H., Heidari-Beni, M., & Asgari, G. H. (2021). Dietary fatty acid intakes and the outcomes of assisted reproductive technique in infertile women. Journal of Reproduction & Infertility, 22(3), 173.
• Lăcătușu, C. M., Grigorescu, E. D., Floria, M., Onofriescu, A., & Mihai, B. M. (2019). The mediterranean diet: From an environment-driven food culture to an emerging medical prescription. International Journal of Environmental Research And Public Health, 16(6), 942.
• Liu, Y., He, X. Q., Huang, X., Ding, L., Xu, L., Shen, Y. T., ... & Wang, H. L. (2013). Resveratrol protects mouse oocytes from methylglyoxal-induced oxidative damage. Plos One, 8(10), e77960.
• Mirabi, P., Chaichi, M. J., Esmaeilzadeh, S., Ali Jorsaraei, S. G., Bijani, A., & Ehsani, M. (2017). The role of fatty acids on ICSI outcomes: a prospective cohort study. Lipids in Health and Disease, 16(1), 1-9.
• Mirabi, P., Chaichi, M. J., Esmaeilzadeh, S., Jorsaraei, S. G. A., Bijani, A., & Ehsani, M. (2017). Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid?. Taiwanese Journal of Obstetrics and Gynecology, 56(2), 159-164.
• Mumford, S. L., Browne, R. W., Kim, K., Nichols, C., Wilcox, B., Silver, R. M., ... & Schisterman, E. F. (2018). Preconception plasma phospholipid fatty acids and fecundability. The Journal of Clinical Endocrinology & Metabolism, 103(12), 4501-4510.
• Nooshkam, M., Varidi, M., & Verma, D. K. (2020). Functional and biological properties of Maillard conjugates and their potential application in medical and food: A review. Food Research International, 131, 109003.
• Plottel, C. S., & Blaser, M. J. (2011). Microbiome and malignancy. Cell Host & Microbe, 10(4), 324-335.
• Rezende, E. S. V., Lima, G. C., & Naves, M. M. V. (2021). Dietary fibers as beneficial microbiota modulators: A proposed classification by prebiotic categories. Nutrition, 89, 111217.
• Rienzi, L., Vajta, G., & Ubaldi, F. (2011). Predictive value of oocyte morphology in human IVF: a systematic review of the literature. Human Reproduction Update, 17(1), 34-45.
• Rossi, B. V., Abusief, M., & Missmer, S. A. (2016). Modifiable risk factors and infertility: what are the connections?. American Journal of Lifestyle Medicine, 10(4), 220-231.
• Sanches-Silva, A., Testai, L., Nabavi, S. F., Battino, M., Devi, K. P., Tejada, S., ... & Farzaei, M. H. (2020). Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway. Pharmacological Research, 152, 104626.
• Shah, K. N., & Patel, S. S. (2016). Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome. Pharmaceutical Biology, 54(6), 975-983.
• Silvestris, E., de Pergola, G., Rosania, R., & Loverro, G. (2018). Obesity as disruptor of the female fertility. Reproductive Biology and Endocrinology, 16(1), 1-13.
• Simopoulos, A. P. (2002). The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, 56(8), 365-379.
• Simopoulos, A. P. (2008). The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pacific Journal of Clinical Nutrition, 17.
• Skoracka, K., Ratajczak, A. E., Rychter, A. M., Dobrowolska, A., & Krela-Kaźmierczak, I. (2021). Female Fertility and the Nutritional Approach: The Most Essential Aspects. Advances in Nutrition, 12(6), 2372-2386.
• Sun, H., Lin, Y., Lin, D., Zou, C., Zou, X., Fu, L., ... & Qian, W. (2019). Mediterranean diet improves embryo yield in IVF: a prospective cohort study. Reproductive Biology and Endocrinology, 17(1), 1-7.
• Sunita, P., & Pattanayak, S. P. (2011). Phytoestrogens in postmenopausal indications: A theoretical perspective. Pharmacognosy Reviews, 5(9), 41.
• Toledo, E., Lopez-del Burgo, C., Ruiz-Zambrana, A., Donazar, M., Navarro-Blasco, Í., Martínez-González, M. A., & de Irala, J. (2011). Dietary patterns and difficulty conceiving: a nested case–control study. Fertility and Sterility, 96(5), 1149-1153.
• Wang, X. N., Zhang, C. J., Diao, H. L., & Zhang, Y. (2017). Protective effects of curcumin against sodium arsenite-induced ovarian oxidative injury in a mouse model. Chinese Medical Journal, 130(09), 1026-1032.
• Weber, P. C., Fischer, S., Schacky, C. V., Lorenz, R., & Strasser, T. (1986). The conversion of dietary eicosapentaenoic acid to prostanoids and leukotrienes in man. Progress in Lipid Research, 25, 273-276.
• Williamson, G., & Holst, B. (2008). Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?. British Journal of Nutrition, 99(S3), S55-S58.
• Vujkovic, M., de Vries, J. H., Lindemans, J., Macklon, N. S., van der Spek, P. J., Steegers, E. A., & Steegers-Theunissen, R. P. (2010). The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertility and Sterility, 94(6), 2096-2101.
• y Abreu, A. A., Milke-García, M. P., Argüello-Arévalo, G. A., Calderón-de la Barca, A. M., Carmona-Sánchez, R. I., Consuelo-Sánchez, A., ... & Vázquez-Frias, R. (2021). Dietary fiber and the microbiota: A narrative review by a group of experts from the Asociación Mexicana de Gastroenterología. Revista de Gastroenterología de México (English Edition), 86(3), 287-304.
• Zarezadeh, R., Mehdizadeh, A., Leroy, J. L., Nouri, M., Fayezi, S., & Darabi, M. (2019). Action mechanisms of n‐3 polyunsaturated fatty acids on the oocyte maturation and developmental competence: Potential advantages and disadvantages. Journal of Cellular Physiology, 234(2), 1016-1029.
• Zhang, C., Mumford, S. L., & Gaskins, A. J. (2009). Effect of daily fiber intake on reproductive function: the BioCycle Study.