Review
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Year 2025, Volume: 7 Issue: 2, 37 - 45, 29.09.2025
https://doi.org/10.59124/guhes.1595201

Abstract

References

  • Aas, A, M., Axelsen, M., Churuangsuk, C., Hermansen, K., Kendall, C. W. C., Kahleova, H., Khan, T., Lean, M. E. J., Mann, J. I., Pedersen, E., Pfeiffer, A., Rahelić, D., Reynolds, A. N., Risérus, U., Rivellese, A. A., Salas-Salvadó, J., Schwab, U., Sievenpiper, J. L., Thanopoulou, A., & Nutrition Study Group of the European Association for the Study of Diabetes. (2023). Evidence-based European recommendations for the dietary management of diabetes. Diabetologia, 66(6), 965-985. https://doi.org/10.1007/s00125-023-05894-8
  • Barber, T. M., Hanson, P., Kabisch, S., Pfeiffer, A. F., & Weickert, M. O. (2021). The low-carbohydrate diet: Short-term metabolic efficacy versus longer-term limitations. Nutrients, 13(4), 1187. https://doi.org/10.3390/nu13041187
  • Bazzano, L. A., Hu, T., Reynolds, K., Yao, L., Bunol, C., Liu, Y., Chen, C.-S., Klag, M. J., Whelton, P. K., & He, J. (2014). Effects of low-carbohydrate and low-fat diets: A randomized trial. Annals of Internal Medicine, 161(5), 309-318. https://doi.org/10.7326/M14-0180
  • Bueno, N. B., de Melo, I. S., de Oliveira, S. L., & da Rocha Ataide, T. (2013). Very-low-carbohydrate ketogenic diet vs. low-fat diet for long-term weight loss: A meta-analysis of randomized controlled trials. British Journal of Nutrition, 110(7), 1178-1187. https://doi.org/10.1017/s0007114513000548
  • Cronin, P., Joyce, S. A., O'Toole, P. W., & O'Connor, E. M. (2021). Dietary fibre modulates the gut microbiota. Nutrients, 13(5), 1655. https://doi.org/10.3390/nu13051655
  • Chen, R., & Chen, G. (2022). Personalized nutrition for people with diabetes and at risk of diabetes has begun. Journal of Future Foods, 2(3), 193-202.
  • Dorans, K. S., Bazzano, L. A., Qi, L., He, H., Chen, J., Appel, L. J., Chen, C.-S., Hsieh, M.-H., Hu, F. B., & Mills, K. T. (2022). Effects of a low-carbohydrate dietary intervention on hemoglobin A1c: A randomized clinical trial. JAMA Network Open, 5(10), e2238645-e2238645. https://doi.org/10.1001/jamanetworkopen.2022.38645
  • Ebrahimpour-Koujan, S., Keshteli, A. H., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2019). Adherence to low carbohydrate diet and prevalence of psychological disorders in adults. Journal of Nutrition, 18(1):87.https://doi.org/10.1186/s12937-019-0513-8
  • Feinman, R, D., Pogozelski, W, K., Astrup, A., Bernstein, R, K., Fine, E, J., Westman, E, C., Accurso, A., Frassetto, L., Gower, B, A., McFarlane, S, I., Nielsen, J, V., Krarup, T., Saslow, L., Roth, K, S., Vernon, M, C., Volek, J, S., Wilshire, G, B., Dahlqvist, A., Sundberg, R., Childers, A., Morrison, K., Manninen, A, H., Dashti, H, M., Wood, R, J., Wortman, J., Worm, N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13. doi: 10.1016/j.nut.2014.06.011.
  • Gardner, C. D., Trepanowski, J. F., Del Gobbo, L. C., Hauser, M. E., Rigdon, J., Ioannidis, J. P., Desai, M., & King, A. C. (2018). Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: The dietdits randomized clinical trial. JAMA, 319(7), 667-679. https://doi.org/10.1001/jama.2018.0245
  • Hall, K. D., Bemis, T., Brychta, R., Chen, K. Y., Courville, A., Crayner, E. J., Goodwin, S., Guo, J., Howard, L., & Knuth, N. D. (2015). Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell Metabolism, 22(3), 427-436. https://doi.org/10.1016/j.cmet.2015.07.021
  • Hite, A. H., Berkowitz, V. G., & Berkowitz, K. (2011). Low‐carbohydrate diet review: Shifting the paradigm. Nutrition in Clinical Practice, 26(3), 300-308. https://doi.org/10.1177/0884533611405791
  • Juanola-Falgarona, M., Salas-Salvadó, J., Ibarrola-Jurado, N., Rabassa-Soler, A., Díaz-López, A., Guasch-Ferré, M., Hernández-Alonso, P., Balanza, R., & Bulló, M. (2014). Effect of the glycemic index of the diet on weight loss, modulation of satiety, inflammation, and other metabolic risk factors: A randomized controlled trial. The American Journal of Clinical Nutrition, 100(1), 27-35. https://doi.org/10.3945/ajcn.113.081216
  • Ludwig DS, Ebbeling CB. (2018). The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out". JAMA Internal Medicine, Aug 1;178(8):1098-1103. doi: 10.1001/jamainternmed.2018.2933. PMID: 29971406; PMCID: PMC6082688.
  • Ludwig, D. S., Apovian, C. M., Aronne, L. J., Astrup, A., Cantley, L. C., Ebbeling, C. B., Heymsfield, S. B., Johnson, J. D., King, J. C., & Krauss, R. M. (2022). Competing paradigms of obesity pathogenesis: Energy balance versus carbohydrate-insulin models. European Journal of Clinical Nutrition, 76(9), 1209-1221. https://doi.org/10.1038/s41430-022-01179-2
  • Ludwig, D. S., Aronne, L. J., Astrup, A., de Cabo, R., Cantley, L. C., Friedman, M. I., Heymsfield, S. B., Johnson, J. D., King, J. C., & Krauss, R. M. (2021). The carbohydrate-insulin model: A physiological perspective on the obesity pandemic. The American Journal of Clinical Nutrition, 114(6), 1873-1885. https://doi.org/10.1093/ajcn/nqab270
  • Ludwig, D. S., & Friedman, M. I. (2014). Increasing adiposity: Consequence or cause of overeating? JAMA, 311(21), 2167-2168. https://doi.org/10.1001/jama.2014.4133
  • Krogh-Madsen R, Plomgaard P, Møller K, Mittendorfer B, Pedersen BK. (2006). Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans. Am Journal Physiol Endocrinol Metabolisma. Jul;291(1):E108-14. doi: 10.1152/ajpendo.00471.2005.
  • Manzano, M., Giron, M. D., Salto, R., Vilchez, J. D., Reche-Perez, F. J., Cabrera, E., Linares-Pérez, A., Plaza-Díaz, J., Ruiz-Ojeda, F. J., & Gil, A. (2022). Quality more than quantity: The use of carbohydrates in high-fat diets to tackle obesity in growing rats. Frontiers in Nutrition, 9, 112-119. https://doi.org/10.3389/fnut.2022.809865
  • Petersen KF, Shulman GI. (2006). Etiology of insulin resistance. Am Journal Medicine. May; 119(5 Suppl 1): S10-6. doi: 10.1016/j.amjmed.2006.01.009.
  • Popp, C. J., Hu, L., Kharmats, A. Y., Curran, M., Berube, L., Wang, C., & Sevick, M. A. (2022). Effect of a personalized diet to reduce postprandial glycemic response vs a low-fat diet on weight loss in adults with abnormal glucose metabolism and obesity: a randomized clinical trial. JAMA, 5(9), e2233760-e2233760.
  • Reynolds, A., Mann, J., Cummings, J., Winter, N., Mete, E., & Te Morenga, L. (2019). Carbohydrate quality and human health: A series of systematic reviews and meta-analyses. Lancet, 393(10170), 434-445. https://doi.org/10.1016/S0140-6736(18)31809-9.
  • Sampaio, L.P. (2016). Ketogenic diet for epilepsy treatment. Arquivos de Neuro-Psiquiatria. 74, 842–848. doi: 10.1590/0004-282X20160116.
  • Sartorius, K., Sartorius, B., Madiba, T. E., & Stefan, C. (2018). Does high-carbohydrate intake lead to increased risk of obesity? A systematic review and meta-analysis. BMJ Open, 8(2), e018449. https://doi.org/10.1136/bmjopen-2017-018449.
  • Shi C, Zhu L, Chen X, Gu N, Chen L, Zhu L, Yang L, Pang L, Guo X, Ji C, Zhang C. (2014). IL-6 and TNF-α induced obesity-related inflammatory response through transcriptional regulation of miR-146b. Journal of Interferon & Cytokine Research. May;34(5):342-8. doi: 10.1089/jir.2013.0078.
  • Sievenpiper, J. L. (2020). Low-carbohydrate diets and cardiometabolic health: The importance of carbohydrate quality over quantity. Nutrition Reviews, 78 (Supplement_1), 69-77. https://doi.org/10.1093/nutrit/nuz082.
  • Siverhus, K. (2019). Low-carbohydrate and very low carbohydrate eating patterns in adults with diabetes. Houston, Texas.
  • Ss, P. (2023). Energy-balance and carbohydrate-insulin models of obesity are not competing propositions. International Journal of Obesity, 47(2), 95-97. https://doi.org/10.1038/s41366-022-01249-2
  • Taubes G. (2007). Good calories, bad calories: challenging the conventional wisdom on diet, weight control, and disease. https://archive.org/details/goodcaloriesbadc0000taub.
  • Teicholz, N., Croft, S. M., Cuaranta, I., Cucuzzella, M., Glandt, M., Griauzde, D. H., Jerome-Zapadka, K., Kalayjian, T., Murphy, K., Nelson, M., Shanahan, C., Nishida, J. L., Oh, R. C., Parrella, N., Saner, E. M., Sethi, S., Volek, J. S., Williden, M., & Wolver, S. (2025). Myths and Facts Regarding Low-Carbohydrate Diets. Nutrients, 17(6), 1047. https://doi.org/10.3390/nu17061047
  • Teuta Gjuladin-Hellon, Ian G Davies, Peter Penson, Raziyeh Amiri Baghbadorani, (2019). Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis, Nutrition Reviews, 77(3) ,161–180), https://doi.org/10.1093/nutrit/nuy049
  • Thibault, R., Abbasoglu, O., Ioannou, E., Meija, L., Ottens-Oussoren, K., Pichard, C., Rothenberg, E., Rubin, D., Siljamäki-Ojansuu, U., & Vaillant, M.-F. (2021). ESPEN guideline on hospital nutrition. Clinical Nutrition, 40(12), 5684-5709. https://doi.org/10.1016/j.clnu.2021.09.039
  • Tricò, D., Moriconi, D., Berta, R., Baldi, S., Quinones-Galvan, A., Guiducci, L., Taddei, S., Mari, A., & Nannipieri, M. (2021). Effects of low-carbohydrate versus Mediterranean diets on weight loss, glucose metabolism, insulin kinetics and β-cell function in morbidly obese individuals. Nutrients, 13(4), 1345. https://doi.org/10.3390/nu13041345
  • Turner-McGrievy, G., Wirth, M. D., Hill, K. L., Dear, E. R., & Hébert, J. R. (2021). Examining commonalities and differences in food groups, nutrients, and diet quality among popular diets. Clinical Nutrition Reports . ESPEN. 2021 Feb:41:377-385. https://doi.org/10.1016/j.clnesp.2020.10.017
  • Wei, J., Heng, W., & Gao, J. (2016). Effects of low glycemic index diets on gestational diabetes mellitus: A meta-analysis of randomized controlled clinical trials. Medicine, 95(22), e3792. https://doi.org/10.1097/MD.0000000000003792
  • World Health Organization (WHO). (2023, June 28). 6 facts on obesity. Retrieved from. https://www.who.int/news-room/facts-in-pictures/detail/6-facts-on-obesity
  • Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., & Segal, E. (2015). Personalized nutrition by prediction of glycemic responses. Cell, 163(5), 1079-1094.

Carbohydrate-Insulin Model In Obesity- An Updated Review

Year 2025, Volume: 7 Issue: 2, 37 - 45, 29.09.2025
https://doi.org/10.59124/guhes.1595201

Abstract

The prevalence of obesity is increasing rapidly worldwide and represents a serious public health problem. In order to prevent obesity, the causes of obesity should be identified and appropriate interventions developed. In this review, the carbohydrate-insulin model, which is one of the causal perspectives to obesity, and recent studies on this approach are discussed and evaluated together with the energy balance model. Reduced total energy expenditure when adhering to healthy dietary recommendations without energy restriction or dietary energy restriction interventions makes it difficult to understand the energy-independent insulinemic effect of diet. Although more studies are needed on the causal approaches to obesity, it was concluded that high-fibre and low-glycaemic load diets, rather than carbohydrate-restricted diets in the carbohydrate-insulin model, may give more favorable results in trials. In addition, individualized nutritional and dietary models should be developed under the guidance of a dietician in the treatment of obesity.

Supporting Institution

No funding was received for this study.

References

  • Aas, A, M., Axelsen, M., Churuangsuk, C., Hermansen, K., Kendall, C. W. C., Kahleova, H., Khan, T., Lean, M. E. J., Mann, J. I., Pedersen, E., Pfeiffer, A., Rahelić, D., Reynolds, A. N., Risérus, U., Rivellese, A. A., Salas-Salvadó, J., Schwab, U., Sievenpiper, J. L., Thanopoulou, A., & Nutrition Study Group of the European Association for the Study of Diabetes. (2023). Evidence-based European recommendations for the dietary management of diabetes. Diabetologia, 66(6), 965-985. https://doi.org/10.1007/s00125-023-05894-8
  • Barber, T. M., Hanson, P., Kabisch, S., Pfeiffer, A. F., & Weickert, M. O. (2021). The low-carbohydrate diet: Short-term metabolic efficacy versus longer-term limitations. Nutrients, 13(4), 1187. https://doi.org/10.3390/nu13041187
  • Bazzano, L. A., Hu, T., Reynolds, K., Yao, L., Bunol, C., Liu, Y., Chen, C.-S., Klag, M. J., Whelton, P. K., & He, J. (2014). Effects of low-carbohydrate and low-fat diets: A randomized trial. Annals of Internal Medicine, 161(5), 309-318. https://doi.org/10.7326/M14-0180
  • Bueno, N. B., de Melo, I. S., de Oliveira, S. L., & da Rocha Ataide, T. (2013). Very-low-carbohydrate ketogenic diet vs. low-fat diet for long-term weight loss: A meta-analysis of randomized controlled trials. British Journal of Nutrition, 110(7), 1178-1187. https://doi.org/10.1017/s0007114513000548
  • Cronin, P., Joyce, S. A., O'Toole, P. W., & O'Connor, E. M. (2021). Dietary fibre modulates the gut microbiota. Nutrients, 13(5), 1655. https://doi.org/10.3390/nu13051655
  • Chen, R., & Chen, G. (2022). Personalized nutrition for people with diabetes and at risk of diabetes has begun. Journal of Future Foods, 2(3), 193-202.
  • Dorans, K. S., Bazzano, L. A., Qi, L., He, H., Chen, J., Appel, L. J., Chen, C.-S., Hsieh, M.-H., Hu, F. B., & Mills, K. T. (2022). Effects of a low-carbohydrate dietary intervention on hemoglobin A1c: A randomized clinical trial. JAMA Network Open, 5(10), e2238645-e2238645. https://doi.org/10.1001/jamanetworkopen.2022.38645
  • Ebrahimpour-Koujan, S., Keshteli, A. H., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2019). Adherence to low carbohydrate diet and prevalence of psychological disorders in adults. Journal of Nutrition, 18(1):87.https://doi.org/10.1186/s12937-019-0513-8
  • Feinman, R, D., Pogozelski, W, K., Astrup, A., Bernstein, R, K., Fine, E, J., Westman, E, C., Accurso, A., Frassetto, L., Gower, B, A., McFarlane, S, I., Nielsen, J, V., Krarup, T., Saslow, L., Roth, K, S., Vernon, M, C., Volek, J, S., Wilshire, G, B., Dahlqvist, A., Sundberg, R., Childers, A., Morrison, K., Manninen, A, H., Dashti, H, M., Wood, R, J., Wortman, J., Worm, N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13. doi: 10.1016/j.nut.2014.06.011.
  • Gardner, C. D., Trepanowski, J. F., Del Gobbo, L. C., Hauser, M. E., Rigdon, J., Ioannidis, J. P., Desai, M., & King, A. C. (2018). Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: The dietdits randomized clinical trial. JAMA, 319(7), 667-679. https://doi.org/10.1001/jama.2018.0245
  • Hall, K. D., Bemis, T., Brychta, R., Chen, K. Y., Courville, A., Crayner, E. J., Goodwin, S., Guo, J., Howard, L., & Knuth, N. D. (2015). Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell Metabolism, 22(3), 427-436. https://doi.org/10.1016/j.cmet.2015.07.021
  • Hite, A. H., Berkowitz, V. G., & Berkowitz, K. (2011). Low‐carbohydrate diet review: Shifting the paradigm. Nutrition in Clinical Practice, 26(3), 300-308. https://doi.org/10.1177/0884533611405791
  • Juanola-Falgarona, M., Salas-Salvadó, J., Ibarrola-Jurado, N., Rabassa-Soler, A., Díaz-López, A., Guasch-Ferré, M., Hernández-Alonso, P., Balanza, R., & Bulló, M. (2014). Effect of the glycemic index of the diet on weight loss, modulation of satiety, inflammation, and other metabolic risk factors: A randomized controlled trial. The American Journal of Clinical Nutrition, 100(1), 27-35. https://doi.org/10.3945/ajcn.113.081216
  • Ludwig DS, Ebbeling CB. (2018). The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out". JAMA Internal Medicine, Aug 1;178(8):1098-1103. doi: 10.1001/jamainternmed.2018.2933. PMID: 29971406; PMCID: PMC6082688.
  • Ludwig, D. S., Apovian, C. M., Aronne, L. J., Astrup, A., Cantley, L. C., Ebbeling, C. B., Heymsfield, S. B., Johnson, J. D., King, J. C., & Krauss, R. M. (2022). Competing paradigms of obesity pathogenesis: Energy balance versus carbohydrate-insulin models. European Journal of Clinical Nutrition, 76(9), 1209-1221. https://doi.org/10.1038/s41430-022-01179-2
  • Ludwig, D. S., Aronne, L. J., Astrup, A., de Cabo, R., Cantley, L. C., Friedman, M. I., Heymsfield, S. B., Johnson, J. D., King, J. C., & Krauss, R. M. (2021). The carbohydrate-insulin model: A physiological perspective on the obesity pandemic. The American Journal of Clinical Nutrition, 114(6), 1873-1885. https://doi.org/10.1093/ajcn/nqab270
  • Ludwig, D. S., & Friedman, M. I. (2014). Increasing adiposity: Consequence or cause of overeating? JAMA, 311(21), 2167-2168. https://doi.org/10.1001/jama.2014.4133
  • Krogh-Madsen R, Plomgaard P, Møller K, Mittendorfer B, Pedersen BK. (2006). Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans. Am Journal Physiol Endocrinol Metabolisma. Jul;291(1):E108-14. doi: 10.1152/ajpendo.00471.2005.
  • Manzano, M., Giron, M. D., Salto, R., Vilchez, J. D., Reche-Perez, F. J., Cabrera, E., Linares-Pérez, A., Plaza-Díaz, J., Ruiz-Ojeda, F. J., & Gil, A. (2022). Quality more than quantity: The use of carbohydrates in high-fat diets to tackle obesity in growing rats. Frontiers in Nutrition, 9, 112-119. https://doi.org/10.3389/fnut.2022.809865
  • Petersen KF, Shulman GI. (2006). Etiology of insulin resistance. Am Journal Medicine. May; 119(5 Suppl 1): S10-6. doi: 10.1016/j.amjmed.2006.01.009.
  • Popp, C. J., Hu, L., Kharmats, A. Y., Curran, M., Berube, L., Wang, C., & Sevick, M. A. (2022). Effect of a personalized diet to reduce postprandial glycemic response vs a low-fat diet on weight loss in adults with abnormal glucose metabolism and obesity: a randomized clinical trial. JAMA, 5(9), e2233760-e2233760.
  • Reynolds, A., Mann, J., Cummings, J., Winter, N., Mete, E., & Te Morenga, L. (2019). Carbohydrate quality and human health: A series of systematic reviews and meta-analyses. Lancet, 393(10170), 434-445. https://doi.org/10.1016/S0140-6736(18)31809-9.
  • Sampaio, L.P. (2016). Ketogenic diet for epilepsy treatment. Arquivos de Neuro-Psiquiatria. 74, 842–848. doi: 10.1590/0004-282X20160116.
  • Sartorius, K., Sartorius, B., Madiba, T. E., & Stefan, C. (2018). Does high-carbohydrate intake lead to increased risk of obesity? A systematic review and meta-analysis. BMJ Open, 8(2), e018449. https://doi.org/10.1136/bmjopen-2017-018449.
  • Shi C, Zhu L, Chen X, Gu N, Chen L, Zhu L, Yang L, Pang L, Guo X, Ji C, Zhang C. (2014). IL-6 and TNF-α induced obesity-related inflammatory response through transcriptional regulation of miR-146b. Journal of Interferon & Cytokine Research. May;34(5):342-8. doi: 10.1089/jir.2013.0078.
  • Sievenpiper, J. L. (2020). Low-carbohydrate diets and cardiometabolic health: The importance of carbohydrate quality over quantity. Nutrition Reviews, 78 (Supplement_1), 69-77. https://doi.org/10.1093/nutrit/nuz082.
  • Siverhus, K. (2019). Low-carbohydrate and very low carbohydrate eating patterns in adults with diabetes. Houston, Texas.
  • Ss, P. (2023). Energy-balance and carbohydrate-insulin models of obesity are not competing propositions. International Journal of Obesity, 47(2), 95-97. https://doi.org/10.1038/s41366-022-01249-2
  • Taubes G. (2007). Good calories, bad calories: challenging the conventional wisdom on diet, weight control, and disease. https://archive.org/details/goodcaloriesbadc0000taub.
  • Teicholz, N., Croft, S. M., Cuaranta, I., Cucuzzella, M., Glandt, M., Griauzde, D. H., Jerome-Zapadka, K., Kalayjian, T., Murphy, K., Nelson, M., Shanahan, C., Nishida, J. L., Oh, R. C., Parrella, N., Saner, E. M., Sethi, S., Volek, J. S., Williden, M., & Wolver, S. (2025). Myths and Facts Regarding Low-Carbohydrate Diets. Nutrients, 17(6), 1047. https://doi.org/10.3390/nu17061047
  • Teuta Gjuladin-Hellon, Ian G Davies, Peter Penson, Raziyeh Amiri Baghbadorani, (2019). Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis, Nutrition Reviews, 77(3) ,161–180), https://doi.org/10.1093/nutrit/nuy049
  • Thibault, R., Abbasoglu, O., Ioannou, E., Meija, L., Ottens-Oussoren, K., Pichard, C., Rothenberg, E., Rubin, D., Siljamäki-Ojansuu, U., & Vaillant, M.-F. (2021). ESPEN guideline on hospital nutrition. Clinical Nutrition, 40(12), 5684-5709. https://doi.org/10.1016/j.clnu.2021.09.039
  • Tricò, D., Moriconi, D., Berta, R., Baldi, S., Quinones-Galvan, A., Guiducci, L., Taddei, S., Mari, A., & Nannipieri, M. (2021). Effects of low-carbohydrate versus Mediterranean diets on weight loss, glucose metabolism, insulin kinetics and β-cell function in morbidly obese individuals. Nutrients, 13(4), 1345. https://doi.org/10.3390/nu13041345
  • Turner-McGrievy, G., Wirth, M. D., Hill, K. L., Dear, E. R., & Hébert, J. R. (2021). Examining commonalities and differences in food groups, nutrients, and diet quality among popular diets. Clinical Nutrition Reports . ESPEN. 2021 Feb:41:377-385. https://doi.org/10.1016/j.clnesp.2020.10.017
  • Wei, J., Heng, W., & Gao, J. (2016). Effects of low glycemic index diets on gestational diabetes mellitus: A meta-analysis of randomized controlled clinical trials. Medicine, 95(22), e3792. https://doi.org/10.1097/MD.0000000000003792
  • World Health Organization (WHO). (2023, June 28). 6 facts on obesity. Retrieved from. https://www.who.int/news-room/facts-in-pictures/detail/6-facts-on-obesity
  • Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., & Segal, E. (2015). Personalized nutrition by prediction of glycemic responses. Cell, 163(5), 1079-1094.
There are 37 citations in total.

Details

Primary Language English
Subjects Health Services and Systems (Other)
Journal Section Review
Authors

Buket Akyakar 0000-0003-0545-5680

Yasemin Akdevelioğlu 0000-0002-2213-4419

Publication Date September 29, 2025
Submission Date December 2, 2024
Acceptance Date May 6, 2025
Published in Issue Year 2025 Volume: 7 Issue: 2

Cite

APA Akyakar, B., & Akdevelioğlu, Y. (2025). Carbohydrate-Insulin Model In Obesity- An Updated Review. Journal of Gazi University Health Sciences Institute, 7(2), 37-45. https://doi.org/10.59124/guhes.1595201