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Year 2011, Volume: 24 Issue: 3, 407 - 413, 25.11.2011

Abstract

References

  • Cozzi, P. G., “Metal-salen Schiff base complexes in catalysis: practical aspects”, Chem. Soc. Rev., 33, 410-421, (2004).
  • Sallam, S. A., “Binuclear copper(II), nickel(II) and Cobalt(II) complexes with N2O2 chromophores of glycylglycine benzoylacetone and thenoyltrifluoroacetone”, Trans. Met. Chem., 31, 46-55, (2006). of acetylacetone,
  • Ren, S., Wang, R., Komatsu, K., Bonaz-Krause, P., Zyrianov, Y., McKenna, C. E., Csipke, C., Tokes, Z. A., Lien, E. J., “Synthesis, biological evaluation and quantitative structure-activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents”, J. Med. Chem., 45, 410-419, (2002).
  • Panneerselvam, P., Nair, R. R., Vijayalakshmi, G., Subramanian, E. H., Sridhar, S. K.,” Synthesis of Schiff bases of 4-(4-aminophenyl)morpholine as potential antimicrobial agents”, Eur. J. Med. Chem., 40, 225-229, (2005).
  • Vicini, P., Geronikaki, A., Incerti, M., Busonera, B., Poni, G., Cabrasc, C. A., Collac, P. L.,”Synthesis and biological evaluation of benzoisothiazole, benzothiazole and thiazole Schiff bases”, Bioorg. Med. Chem., 11, 4785-4789, (2003).
  • Kasumov, V. T., Ozalp-Yaman, S., Tas, E.,” Synthesis, behaviors of nickel (II) complexes with tetradentate Schiff bases derived from 3,5-But2-salicylaldehyde”, Spectrochim. Acta A, 62, 716-720, (2005).
  • Frausto da Silva J., Williams, R., “The biological chemistry of the elements“, Clarendon Press, Oxford, (1991).
  • Kaim, W., Schwederski, B., “Bioinorganic chemistry: Inorganic elements in the chemistry of life”, Wiley, New York, (1996).
  • Khandar A. A., Hosseini-Yazdi, S. A., Zarei, S. A., Rabie, U. M., “Synthesis, characterization and X-ray crystal structures of copper(II) and nickel(II) complexes with potentially hexadentate Schiff base ligands”, Inorg. Chim. Acta., 358, 3211-3217, (2005).
  • Heidelberger, C., “Fluorinated pyrimidines”, Progr. Nucl. Acid Res. Mol. Biol., 4, 1, (1965).
  • Roy-Burman, P., “Analogues of Nucleic Acid Components”, Springer-Verlag, New York, (1970).
  • Hueso-Urena, F., Illan-Cabeza, N.A., Moreno- Carretero, M.N., Martinez-Martos, J.M. and Ramirez-Exposito, spectroscopic studies on the new Schiff base derived from the 1:2 condensation of 2,6-diformyl-4- methylphenol with 5-aminouracil (BDF5AU) and its transition biologically aminopeptidases”, J. Inorg. Biochem., 94, 326-334, (2003). “Synthesis and metal complexes. Influence
  • peptides-regulating active
  • Uno, J., Shýgematsu, M. L. and Araý,T., “Primary Site of Action of Ketoconazole on Candida albicans”, Chemotherapy, 21, 6, 912-918, (1982). Agents and
  • Özdemir, N., Dinçer, M., Doğaner, G., Astley, D. and Astley, S. T., “trans-Diaqua{5,5’-[(E,E)- pyridine-2,6-diylbis(methylidynenitrilo)]bis- [pyrimidine-2,4(1H,3H)-dione)}-zinc(II) hexafluorophosphate trihydrate”, Acta Cryst., C63, m147, (2007). nitrate
  • Koz, G., Özdemir, N., Astley, D., Dinçer, M. and Astley, S. T. “Synthesis, spectroscopic and structural characterization of cobalt(II) complex with uracil- conaining 2,6-diformylpyridine ligand: Theoretical studies on the ligand and pentagonal-bipyramidal [Co(L)(H2O)2]2+ and [Zn(L)(H2O)2]2+ cations”, Journal of Molecular Structure, 966, 39-47, (2010).
  • Hueso-Urena, F., Penas-Chamorro, A.L., Moreno- Carretero, M.N., Amigo, J.M., Esteve, V. and Debaerdemaeker, T., “Synthesis and spectral studies on metal complexes with the neutral O,N,O- tridentate dimethyluracil-benzoylhydrazone crystal structure of a bidimensionally hydrogen- bonded perchlorate copper(II) complex”, Polyhedron, 18, 16, 2205- 2210, (1999).
  • amino-5-formyl1,3

Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil

Year 2011, Volume: 24 Issue: 3, 407 - 413, 25.11.2011

Abstract

The synthesis, spectroscopic and biological activity studies of Ni(II), Cu(II) and Co(II) complexes of Schiff base ligands derived from 5-aminouracil, 2-hydroxy-1-naphtaldehyde, 2,4-dihydroxybenzaldehyde and salicylaldehyde are reported. In all cases, the complexes appear to be monomeric. The ligands coordinate in bidentate fashion to Ni(II) and Co(II) but in a tridentate fashion to Cu(II) by coordinating to the carbonyl oxygen atom in the 4th position of uracil ring. The biological activities of the Schiff bases and metal complexes have been tested in vitro against a number of bacteria and a fungus. Ni(II) complexes derived from the saliciylaldehyde Schiff base ligand showed good antimicrobial activity whereas a Co(II) complex derived from the same ligand showed good anticandidal activity.

 

Key Words: 5-aminouracil, Schiff base, biological activity.

 

References

  • Cozzi, P. G., “Metal-salen Schiff base complexes in catalysis: practical aspects”, Chem. Soc. Rev., 33, 410-421, (2004).
  • Sallam, S. A., “Binuclear copper(II), nickel(II) and Cobalt(II) complexes with N2O2 chromophores of glycylglycine benzoylacetone and thenoyltrifluoroacetone”, Trans. Met. Chem., 31, 46-55, (2006). of acetylacetone,
  • Ren, S., Wang, R., Komatsu, K., Bonaz-Krause, P., Zyrianov, Y., McKenna, C. E., Csipke, C., Tokes, Z. A., Lien, E. J., “Synthesis, biological evaluation and quantitative structure-activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents”, J. Med. Chem., 45, 410-419, (2002).
  • Panneerselvam, P., Nair, R. R., Vijayalakshmi, G., Subramanian, E. H., Sridhar, S. K.,” Synthesis of Schiff bases of 4-(4-aminophenyl)morpholine as potential antimicrobial agents”, Eur. J. Med. Chem., 40, 225-229, (2005).
  • Vicini, P., Geronikaki, A., Incerti, M., Busonera, B., Poni, G., Cabrasc, C. A., Collac, P. L.,”Synthesis and biological evaluation of benzoisothiazole, benzothiazole and thiazole Schiff bases”, Bioorg. Med. Chem., 11, 4785-4789, (2003).
  • Kasumov, V. T., Ozalp-Yaman, S., Tas, E.,” Synthesis, behaviors of nickel (II) complexes with tetradentate Schiff bases derived from 3,5-But2-salicylaldehyde”, Spectrochim. Acta A, 62, 716-720, (2005).
  • Frausto da Silva J., Williams, R., “The biological chemistry of the elements“, Clarendon Press, Oxford, (1991).
  • Kaim, W., Schwederski, B., “Bioinorganic chemistry: Inorganic elements in the chemistry of life”, Wiley, New York, (1996).
  • Khandar A. A., Hosseini-Yazdi, S. A., Zarei, S. A., Rabie, U. M., “Synthesis, characterization and X-ray crystal structures of copper(II) and nickel(II) complexes with potentially hexadentate Schiff base ligands”, Inorg. Chim. Acta., 358, 3211-3217, (2005).
  • Heidelberger, C., “Fluorinated pyrimidines”, Progr. Nucl. Acid Res. Mol. Biol., 4, 1, (1965).
  • Roy-Burman, P., “Analogues of Nucleic Acid Components”, Springer-Verlag, New York, (1970).
  • Hueso-Urena, F., Illan-Cabeza, N.A., Moreno- Carretero, M.N., Martinez-Martos, J.M. and Ramirez-Exposito, spectroscopic studies on the new Schiff base derived from the 1:2 condensation of 2,6-diformyl-4- methylphenol with 5-aminouracil (BDF5AU) and its transition biologically aminopeptidases”, J. Inorg. Biochem., 94, 326-334, (2003). “Synthesis and metal complexes. Influence
  • peptides-regulating active
  • Uno, J., Shýgematsu, M. L. and Araý,T., “Primary Site of Action of Ketoconazole on Candida albicans”, Chemotherapy, 21, 6, 912-918, (1982). Agents and
  • Özdemir, N., Dinçer, M., Doğaner, G., Astley, D. and Astley, S. T., “trans-Diaqua{5,5’-[(E,E)- pyridine-2,6-diylbis(methylidynenitrilo)]bis- [pyrimidine-2,4(1H,3H)-dione)}-zinc(II) hexafluorophosphate trihydrate”, Acta Cryst., C63, m147, (2007). nitrate
  • Koz, G., Özdemir, N., Astley, D., Dinçer, M. and Astley, S. T. “Synthesis, spectroscopic and structural characterization of cobalt(II) complex with uracil- conaining 2,6-diformylpyridine ligand: Theoretical studies on the ligand and pentagonal-bipyramidal [Co(L)(H2O)2]2+ and [Zn(L)(H2O)2]2+ cations”, Journal of Molecular Structure, 966, 39-47, (2010).
  • Hueso-Urena, F., Penas-Chamorro, A.L., Moreno- Carretero, M.N., Amigo, J.M., Esteve, V. and Debaerdemaeker, T., “Synthesis and spectral studies on metal complexes with the neutral O,N,O- tridentate dimethyluracil-benzoylhydrazone crystal structure of a bidimensionally hydrogen- bonded perchlorate copper(II) complex”, Polyhedron, 18, 16, 2205- 2210, (1999).
  • amino-5-formyl1,3
There are 18 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Chemistry
Authors

Gamze Koz

Hale Kaya This is me

Demet Astley This is me

İhsan Yasa

Stephen Astley This is me

Publication Date November 25, 2011
Published in Issue Year 2011 Volume: 24 Issue: 3

Cite

APA Koz, G., Kaya, H., Astley, D., Yasa, İ., et al. (2011). Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil. Gazi University Journal of Science, 24(3), 407-413.
AMA Koz G, Kaya H, Astley D, Yasa İ, Astley S. Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil. Gazi University Journal of Science. November 2011;24(3):407-413.
Chicago Koz, Gamze, Hale Kaya, Demet Astley, İhsan Yasa, and Stephen Astley. “Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil”. Gazi University Journal of Science 24, no. 3 (November 2011): 407-13.
EndNote Koz G, Kaya H, Astley D, Yasa İ, Astley S (November 1, 2011) Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil. Gazi University Journal of Science 24 3 407–413.
IEEE G. Koz, H. Kaya, D. Astley, İ. Yasa, and S. Astley, “Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil”, Gazi University Journal of Science, vol. 24, no. 3, pp. 407–413, 2011.
ISNAD Koz, Gamze et al. “Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil”. Gazi University Journal of Science 24/3 (November 2011), 407-413.
JAMA Koz G, Kaya H, Astley D, Yasa İ, Astley S. Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil. Gazi University Journal of Science. 2011;24:407–413.
MLA Koz, Gamze et al. “Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil”. Gazi University Journal of Science, vol. 24, no. 3, 2011, pp. 407-13.
Vancouver Koz G, Kaya H, Astley D, Yasa İ, Astley S. Synthesis, Characterization and Antimicrobial Screening of Ni(II), Cu(II) and Co(II) Complexes of Some Schiff Base Ligands Derived from 5-Aminouracil. Gazi University Journal of Science. 2011;24(3):407-13.