A Fourier Transform Infrared Spectrophotometry Method Used For Oseltamivir Determination in Pharmaceutical Formulations

Abstract

A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of oseltamivir phosphate (OP) in pharmaceutical formulations. Conventional KBr-spectra were compared for best determination of the active substance in pharmaceutical preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were used in data processing.

 

Key words: FT-IR analysis, oseltamivir, chemometric methods, pharmaceutical analysis.

 

Keywords

• FT-IR analysis, oseltamivir, chemometric methods, pharmaceutical analysis.

References

1. USP XXII (United States Pharmacopoeia, 22nd revision), Convection Inc., Rockville, MD, 809, (1990).
2. Moffat A.C. (ed.), Clarke’s Isolation and Identification Pharmaceutical Society of Great Britain, London, (1986). 2nd Ed., The 3. Ciurczak, E.W. and Pharmaceutical and medical Applications of Near- Infrared Spectroscopy, Marcel Dekker, Inc., New York, 73-105 (2001). Drennen, J.K.III, 4. McClure, W.F., Analysis Fransforms, in Handbook of Near-Infrared Analysis, Burns, D.A. and Ciurczak, E.W., eds, Marcel Dekker, Inc., New York, 181-274 (1992).
3. Garrigues, S., Gallignani, M. and de la Guardia, M. Simultaneous determination of ortho-, meta- and transform 117:1849-1853 (1992).
4. injection-Fourier infrared Analyst,
5. Miller, B.E., Danielson, N.D. and Katon, J.E. Aqueous Infrared Pharmaceutical Analysis of Two Choline Compounds by Flow Injection Analysis Using the CIRCLE Cell, Appl. Spectrosc., 42, 401-405 (1988).
6. Bunaciu, A.A., Aboul-Enein, H.Y.and Fleschin, S. Application of
7. Fourier Transform Infrared spectrometry in pharmaceutical drugs analysis, Applied Spectroscopy Reviews, , 45, 206-219 (2010).
8. Laborde-Kummer, E., Gaudin, K., Joseph- Charles, J., Gheyouche, R. Boudis, H., Dubost, J- P., Development and validation of a rapid capillary electrophoresis method for the determination of oseltamivir phosphate in Tamiflu® and generic versions, J. Pharm. Biomed.Anal., 50, 544-546 (2009).

9. Haleblian, J. and McCrone W., Pharmaceutical applications of polymorphism, J. Pharm.Sci., , 58, 911-929 (1969).
10. Luinge, H.J., Hop, E., Lutz, E.T., van Hemert J.A. and de Jong, E.A., Determination of the fat, protein and lactose content of milk using Fourier transform infrared spectrometry, Anal.Chim.Acta, 284, 419-433 (1993).
11. Wold, H., Research Papers in Statistics, ed. David F.N., Wiley, New York, (19669.
12. Geladi, P. and Kowalski, B.R. Partial least-squares regression: a tutorial Anal.Chim.Acta, , 185, 1-17. (1986).