Spectroscopic Analytical Methods for Detection of Counterfeit Pharmaceutical Preparations – A MiniReview
Year 2013,
Volume: 26 Issue: 3, 407 - 417, 02.10.2013
Y Aboul-eneın
,
Andrei Bunacıu
Serban Fleschın
Abstract
Pharmaceutical counterfeiting is becoming a serious problem all over the world. This paper presents several of the most important methods used to elucidate this problem including near- and mid-infrared spectroscopy, Raman spectroscopy, isotopic characterization, chromatographic and mass spectrometric approaches.
References
- http://www.who.int/medicines/organization.gs m/activities/quality_assurance/cft/counterfeit. ICC Counterfeiting Intelligence Bureau, The International Anti-counterfeiting Directory, ICC Commercial Crime Services, 2008.
- RodionovaO.Ye, Pomerantsev A.L., ‘NIR- based approach to counterfeit-drug detection’, TrAC Trends in Analytical Chemistry 29(8) 795-803 (2010).
- Deisingh K., ‘Pharmaceutical counterfeiting’, Analyst, 130: 271 – 279 ( 2005)
- Wilhelmsen E.C., ‘Encyclopedia of analytical applications, chemistry; instrumentation Determination, vol.15, 2000, pg. 3862-3888 Adulteration
- Cole C., Jones L. and McVeigh J., ‘Adulterants in illicit drugs: a review of empirical evidence’, Drug Testing and Analysis, 2011; 3(2): 89-96
- WHO, Counterfeit Drugs: Guidelines for the Development of Measures Counterfeit Drugs, WHO, Geneva, 1999. to Combat www.gphf.org/web/en/start/index.htm http://www.gphf.org/web_en/projekte/minilab /index.htm, 2003. ICC Commercial Crime Services, http://www.iccwbo.org/ccs/news_archives/20 03/counterfeit_drugs.asp, 2003.
- Roggo Y., Degardin K. and Margot P., Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics, Talanta, 2010; 81(3): 988-995
- Martino R., Malet-Martino M., Gilard V. and Balayssac S., ‘Counterfeit drugs: analytical techniques for their identification’, Analytical &Bioanalytical Chemistry, 2010; 398(1): 77- 92
- Bunaciu A.A., Aboul-Enein H.Y. and Fleschin S., Transform Infrared Spectrophotometry in Pharmaceutical Drugs Analysis’, Applied Spectroscopy Reviews 2010; 45(3): 206-219
- Been F., Roggo Y., Degardin K., Esseiva P. and Margot P., ‘Profiling of counterfeit medicines by vibrational spectroscopy’, Forensic Science International, 2011; 211(1- 3): 83-100
- Dong Y-D. and Boyd B.J., ‘Applications of X-ray scattering in pharmaceutical science’, International Journal of Pharmaceutics, 2011; 417(1-2): 101-111
- Dégardin K., Roggo Y., Been F. and Margot P., ‘Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics’, Anal.Chim.Acta, 2011; 705(1-2): 334-341 Rodionova O. Ye.,
- Pomerantsev A.L., Geladi P., Burger J., Dorofeyev V.L. and Arzamastsev A.P., ‘NIR spectrometry for counterfeit drug detection: A feasibility study’, Anal.Chim.Acta, 2005; 549(1-2): 151-158 L.P.,
- Holzgrabe U. and Malet-Martino M., ‘Analytical challenges in drug counterfeiting and falsification—The NMR approach’, J. of Pharm.&Biomed.Anal., 2011, 55(4), 687 679
- Sharma K. and Paradakar M., ‘The melamine adulteration scandal’, Food Security, 2010; 2(1): 97-107
- Beni S., Limtiaco J.F.K. and Larive C. K., ‘Analysis and characterization of heparin impurities’, Chemistry, 2011; 399(2): 527-539 &Bioanalytical
- Hu C-Q., Zou W-B., Hu W-S., Ma X-K., Yang M-Z., Zhou S-L., Sheng J-F., Yuan Li, Cheng S-H. and Xue J., ‘Establishment of a Fast Chemical Identification System for screening of counterfeit drugs of macrolide antibiotics’, J. of Pharm.&Biomed.Anal., 2006; 40(1): 68-74
- Gaudiano M.C., Di Maggio A., Antoniella E., Valvo L., Bertocchi P., Manna L., Bartolomei M., Alimonti S. and RodomonteA.L.,’An LC method for the simultaneous screening of some common counterfeit and sub-standard antibiotics: estimation’, 2008; 48(2): 303-309 and uncertainty Pharm.&Biomed.Anal.,
- Sanli S., Sanli N., Gumustas M., Ozkan S.A., Karadas N. and Aboul-Enein H.Y., ‘Simultaneous Estimation of Ceftazidime and Ceftizoxime in Pharmaceutical Formulations by HPLC Method’, Chromatographia, 2011; 74(7-8): 549-558
- Ricci C., Eliasson C., Macleod N.A., Newton P.N., Matousek P. and Kazarian S.G., ‘Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs’, Anal.&Bioanal.Chem. 2007; 389(5): 1525-1532
- Ricci C., Nyadong L., Fernandez F.M., Newton P.N. and Kazarian S.G., ‘Combined Fourier-transform desorption electrospray-ionization linear ion- trap mass spectrometry for analysis of counterfeit antimalarial tablets’, Analytical &Bioanalytical Chemistry, 2007; 387(2): 551-559 imaging and Green M.D., Nettey H., Villalva Rojas Ofelia,
- Pamanivong C., Khounsaknalath L., Ortiz M.G., Vongsack L. and OtManolin, ‘Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality’, J. of Pharm.& Biomed. Anal., 2007; 43(1): 105-110 Fernández F.M.,
- Dowell F.E., Maghirang Elizabeth B., Fernandez F.M., Newton P.N. and Green M.D., ‘Detecting counterfeit antimalarial tablets by near-infrared spectroscopy’, J.of Pharm.& Biomed. Anal., 2008; 48(3): 1011- 1014
- Patient Information Sheet Viagra®, US. Department of Health and Human Services, Food RockvilleMD, USA, June 2005. Administration,
- Lindegårdh N., Hien T.T., Farrar J., Singhasivanon P., White N.J. and Day N.P.J., ‘A simple and rapid liquid chromatographic assay for evaluation of potentially counterfeit Tamiflu®’, J. of Pharm.& Biomed. Anal., 2006; 42(4): 430-433
- Vredenbregt M.J., Blok-Tip L., Hoogerbrugge R., Barends D.M. and de Kaste D., ‘Screening suspected counterfeit Viagra® and imitations of Viagra® with near-infrared spectroscopy’, J. of Pharm.& Biomed. Anal., 2006; 40: 840–849.
- Zhou P., Oh S.S.Y., Hou P.L., Low M.Y. and Koh H.L., ‘Simultaneous determination of synthetic found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode chromatography–electrospray tandem mass spectrometry’, J. Chromatogr. A, 2006; 1104: 113–122. inhibitors array and liquid ionization
- Maurin J.K., Pluciński F., Mazurek A.P. and FijałekZbigniew, ‘The usefulness of simple X-ray counterfeit control—The Viagra® example’, J. of Pharm.& Biomed. Anal., 2007; 43(4): 1514-1518 analysis for de Veij M., Deneckere A., Vandenabeele P., de Kaste D. and Moens L., ‘Detection of counterfeit spectroscopy’, J.of Pharm.& Biomed. Anal., 2008; 46(2): 303-309 with Raman
- Sacré P.Y., Deconinck E., Saerens L., De Beer T., Courselle P., Vancauwenberghe R., Chiap P., Crommen J. and De Beer J.O., ‘Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis’, J.of Pharm.& Biomed. Anal., 2011; 56(2): 454-461
- Sacré P.Y., Deconinck E., De Beer T., Courselle P., Vancauwenberghe R., Chiap Patrice, Crommen J. and De Beer J.O., ‘Comparison spectroscopic techniques for the detection of of counterfeit Biomed. Anal., 2010; 53(3): 445-453 J.of Pharm.&
- Xie L-G., Sun H-M. and Jin S-H., ‘Screening adulteration of polypropylene bottles with postconsumer recycled plastics for oral drug package by near-infrared spectroscopy’, Anal.Chim.Acta, 2011; 706(2): 312-320
- Causin V., Marega C., Carresi P., Schiavone S. and differentiation method for plastic bags by infrared spectroscopy, thickness measurement and differential scanning calorimetry for tracing the source of illegal drugs’, Forensic Science International, 2006; 164(2-3): 148- 154 ‘A quantitative de Carvalho L.M., Martini M., Moreira P. A.
- L., de Lima A.P.S., Correia Daniele, Falcão Tatiana, Garcia Solange C., de Bairros A.V., do Nascimento P.C. and Bohrer Denise, Presence of synthetic pharmaceuticals as adulterants in slimming phytotherapeutic formulations determination, International, 2011; 204(1-3): 6-12 analytical Science Forensic
- Zou H-B., Yang G-S., Qin Z.Q. , Jiang W.Q., Ai Qin Du and AboulEnein H.Y., Progress in Quality Control of Herbal Medicine with IR Fingerprint Spectra, Anal.Lett., 2005; 38(9): 1457-1475
- Bunaciu A.A., Aboul-Enein H.Y. and Fleschin S., Recent Applications of Fourier Transform Infrared Spectrophotometry in Herbal Spectroscopy Reviews 2011; 46(4): 251-260 Applied
- Yap K.Y-L.., Chan S.Y. and Lim C.S., Infrared-based protocol for the identification and categorization of ginseng and its products, Food Research International, 2007: 40(5): 643-652
- Vardin H., Abdullatif T., OzenB.andMauer L., Authentication of pomegranate juice concentrate using FTIR spectroscopy and chemometrics, 108(2): 742-748 2008;
- Zhang L. and Nie L., Discrimination of geographical origin and adulteration of radix astragali using fourier transform infrared spectroscopy and chemometric methods, Phytochemical Analysis 2010; 21(6): 609– 615
- Zou P., Hong Y. and Koh H.L., Chemical fingerprinting of Isatisindigotica root by RP- HPLC and hierarchical clustering analysis, J. of Pharm.& Biomed. Anal., 2005; 38(3): 514-520
- Xie P., Chen S., Liang Y-Z., Wang X., Tian R. and Upton R., Chromatographic fingerprint analysis—a rational approach for quality assessment of traditional Chinese herbal medicine, 2006;1112(1-2): 171-180 A,
- Xie G. X., Qiu M. F., Zhao A. H. and Jia W., Fingerprint Analysis of FlosCarthami by Pressurized CEC and LC, Chromatographia, 2006; 64(11-12): 739-743
- Chen C., Zhang H., Xiao W., Yong Z-P. and Bai chromatographic fingerprint analysis for different origins of sea buckthorn berries, J. of Chromatography A, 2007; 1154(1-2): 250- 259 liquid
- Liang Y., Xie P. and Chau F., Chromatographic fingerprinting and related chemometric techniques for quality control of traditional Separation Science 2010; 33(3): 410–421 J. of
- Qiao X., Han J., He W-N., Wu T., Wang B- R., Ye M. and Guo D-A., ‘Chemical fingerprint of commercial Radix Echinopsis and quantitative analysis of α-terthienyl’, J.of Separation Science 2010; 33(4-5): 530–538
- Hu L.F., Li S.P., Cao H., Liu J.J., Gao J.L., Yang F.Q. and Wang Y.T., ‘GC–MS fingerprint of Pogostemoncablin in China’, J. of Pharm.& Biomed. Anal., 2006; 42(2): 200-206
- Marchei E., Pichini S., Pacifici R., Pellegrini M. and Zuccaro P., ‘A rapid and simple procedure for the determination of synephrine in chromatography-mass spectrometry’, J. of Pharm.&Biomed.Anal., 2006; 41(4): 1468- 1472 by gas
- Lucio-Gutiérrez J.R., Coello J. and Maspoch S., ‘Application of near infrared spectral fingerprinting techniques Eleutherococcussenticosus’, Food Research International, 2011; 44(2): 557-565 of
- Nicoletti M. and Petitto V., ‘Contaminations of herbal products determined by NMR fingerprint’, Natural Product Research, 2010; 24(14): 1325-1329
- Sombra L. L., Gómez M. R., Olsina R., Martínez L. D. and Silva M. F., ‘Comparative study between capillary electrophoresis and high performance liquid chromatography in ‘guarana’ based phytopharmaceuticals’,J.of Pharm. & Biomed . Anal ., 2005; 36(5): 989- 994
- Sze S. C-W., Song J-X., Wong R-N-S., Feng Y-B., Ng T-B.,Tong Y. and Zhang K.Y-B., ‘Application characterized amplified region) analysis to authenticate Lyciumbarbarum (wolfberry) and its adulterants’, Biotechnology & Applied Biochemistry, 2008; 51(1): 15–21 (sequence
- Kiran U., Khan S., Mirza K.J., Ram M. and Abdin M.Z., SCAR markers: ‘A potential tool for Fitoterapia, 2010; 81(8): 969-976 herbal drugs’,
- Li M., Jiang R-W., Hon P-M., Cheng L., Li L-L., Zhou J-R., Shaw P-C. and But P.P-H., ‘Authentication of the anti-tumor herb Baihuasheshecao with bioactive compounds and molecular sequences’, Food Chemistry, 2010; 119(3): 1239-1245 marker
- Zou P., Hong Y. and Koh H.L., ‘Chemical fingerprinting of Isatisindigotica root by RP- HPLC and hierarchical clustering analysis’, J. of Pharm.&Biomed.Anal., 2005; 38(3): 514- 520
- Li W., and Fitzloff, J.F., ‘HPLC analysis of ginsenosides in the roots of Asian ginseng (Panax ginseng) and North American ginseng (Panaxquinquefolius) with in-line photodiode array detection’. J. of Liquid Chromatography and Related Technologies, 2002; 25(1): 29–41.
- Kevin Y-L.Y., Chan S.Y. and Chu Lim C.S., of Authentication medicine distinguishing between ginseng and its morphological fakes, J. of Biomedical Science, 2007; 14(2): 265-273 Chinese using infrared spectroscopy:
- Edwards H.G.M., Munshi T. and Page K., Analytical discrimination between sources of ginseng Analytical &Bioanalytical Chemistry, 2007; 389(7-8): 2203-2215 spectroscopy,
- Li Li, Guo-An Luo, Qiong-Lin Liang, Ping Hu and Yi-Ming Wang, Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS, J.of Pharm.& Biomed. Anal., 2010; 52(1): 66-72
- Nelson L., Shih R. and Hoffman R., Aplastic anemia induced by adulterated herbal medication, J. Toxicol. Clin. Toxicol. 1995; 33: 467–470. de Carvalho L.M., Martini M., Moreira A. P.,
- Garcia S. C., do Nascimento P.C. and Denise B., pharmaceuticals in phytotherapeutics by capillary contactless conductivity detection (CZE- C4D), Microchemical Journal, 2010; 96(1): 114-119 of synthetic zone electrophoresis with
- VermaakI., Hamman J.H. and Viljoen A.M., High performance thin layer chromatography as a method to authenticate Hoodia gordonii raw material and products, South African Journal of Botany, 2010; 76(1): 119-124
- Wang J., Chen B. and Yao S., Analysis of six synthetic adulterants in herbal weight- reducing electrospray ionization-MS, Food Additives & Contaminants: Part A, 2008; 25(7): 822- 830 by LC
- Zhang J., Zhang X., Dediu L., Cristea V., Review of the current application of fingerprinting allowing detection of food adulteration and fraud in China, Food Control, 2011; 22(8): 1126-1135
- Reepmeyer J.C. and Woodruff J.T., Use of liquid chromatography–mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a “natural” herbal dietary supplement, J.of Chromatography A, 2006; 1125(1): 67-75 Gryniewicz C. M.,
- Kauffman J.F. and Buhse L. F., ‘Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility Biomed. Anal., 2009; 49(3): 601-606 J.C., J.of Pharm.&
- Singh S., Prasad B. , SavaliyaA.A.,Shah R.P.,. Gohil V.M. and Kaur A., Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, products containing these drugs, TrAC Trends in Analytical Chemistry, 2009, 28(1), 13-28 counterfeit
- Bombardelli, E., Mustich, G., and Bertani, M. (1989). New extracts of Ginkgo biloba and their methods of preparation. European patent 89309500.0 – A61K 35/78.
- Chandra A., Li Y., Rana J., Persons K., Hyun C., Shen S. and Mulder T., Qualitative categorization of supplement grade Ginkgo biloba leaf extracts for authenticity, J. of Functional Foods, 2011; 3(2): 107-114
- Rohman A. and Che Man Y.B., Fourier transform infrared (FTIR) spectroscopy for analysis of extra virgin olive oil adulterated with palm oil, Food Research International, 2010; 43(3): 886-892
- Balasubramani S.P. , Goraya G.S. and Venkatasubramanian P., Development of ITS sequence-based Berberisaristata DC. from B. lyciumRoyle and B. asiaticaRoxb., 3 Biotech, 2011; 1(1): 11-19 to distinguish
Year 2013,
Volume: 26 Issue: 3, 407 - 417, 02.10.2013
Y Aboul-eneın
,
Andrei Bunacıu
Serban Fleschın
References
- http://www.who.int/medicines/organization.gs m/activities/quality_assurance/cft/counterfeit. ICC Counterfeiting Intelligence Bureau, The International Anti-counterfeiting Directory, ICC Commercial Crime Services, 2008.
- RodionovaO.Ye, Pomerantsev A.L., ‘NIR- based approach to counterfeit-drug detection’, TrAC Trends in Analytical Chemistry 29(8) 795-803 (2010).
- Deisingh K., ‘Pharmaceutical counterfeiting’, Analyst, 130: 271 – 279 ( 2005)
- Wilhelmsen E.C., ‘Encyclopedia of analytical applications, chemistry; instrumentation Determination, vol.15, 2000, pg. 3862-3888 Adulteration
- Cole C., Jones L. and McVeigh J., ‘Adulterants in illicit drugs: a review of empirical evidence’, Drug Testing and Analysis, 2011; 3(2): 89-96
- WHO, Counterfeit Drugs: Guidelines for the Development of Measures Counterfeit Drugs, WHO, Geneva, 1999. to Combat www.gphf.org/web/en/start/index.htm http://www.gphf.org/web_en/projekte/minilab /index.htm, 2003. ICC Commercial Crime Services, http://www.iccwbo.org/ccs/news_archives/20 03/counterfeit_drugs.asp, 2003.
- Roggo Y., Degardin K. and Margot P., Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics, Talanta, 2010; 81(3): 988-995
- Martino R., Malet-Martino M., Gilard V. and Balayssac S., ‘Counterfeit drugs: analytical techniques for their identification’, Analytical &Bioanalytical Chemistry, 2010; 398(1): 77- 92
- Bunaciu A.A., Aboul-Enein H.Y. and Fleschin S., Transform Infrared Spectrophotometry in Pharmaceutical Drugs Analysis’, Applied Spectroscopy Reviews 2010; 45(3): 206-219
- Been F., Roggo Y., Degardin K., Esseiva P. and Margot P., ‘Profiling of counterfeit medicines by vibrational spectroscopy’, Forensic Science International, 2011; 211(1- 3): 83-100
- Dong Y-D. and Boyd B.J., ‘Applications of X-ray scattering in pharmaceutical science’, International Journal of Pharmaceutics, 2011; 417(1-2): 101-111
- Dégardin K., Roggo Y., Been F. and Margot P., ‘Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics’, Anal.Chim.Acta, 2011; 705(1-2): 334-341 Rodionova O. Ye.,
- Pomerantsev A.L., Geladi P., Burger J., Dorofeyev V.L. and Arzamastsev A.P., ‘NIR spectrometry for counterfeit drug detection: A feasibility study’, Anal.Chim.Acta, 2005; 549(1-2): 151-158 L.P.,
- Holzgrabe U. and Malet-Martino M., ‘Analytical challenges in drug counterfeiting and falsification—The NMR approach’, J. of Pharm.&Biomed.Anal., 2011, 55(4), 687 679
- Sharma K. and Paradakar M., ‘The melamine adulteration scandal’, Food Security, 2010; 2(1): 97-107
- Beni S., Limtiaco J.F.K. and Larive C. K., ‘Analysis and characterization of heparin impurities’, Chemistry, 2011; 399(2): 527-539 &Bioanalytical
- Hu C-Q., Zou W-B., Hu W-S., Ma X-K., Yang M-Z., Zhou S-L., Sheng J-F., Yuan Li, Cheng S-H. and Xue J., ‘Establishment of a Fast Chemical Identification System for screening of counterfeit drugs of macrolide antibiotics’, J. of Pharm.&Biomed.Anal., 2006; 40(1): 68-74
- Gaudiano M.C., Di Maggio A., Antoniella E., Valvo L., Bertocchi P., Manna L., Bartolomei M., Alimonti S. and RodomonteA.L.,’An LC method for the simultaneous screening of some common counterfeit and sub-standard antibiotics: estimation’, 2008; 48(2): 303-309 and uncertainty Pharm.&Biomed.Anal.,
- Sanli S., Sanli N., Gumustas M., Ozkan S.A., Karadas N. and Aboul-Enein H.Y., ‘Simultaneous Estimation of Ceftazidime and Ceftizoxime in Pharmaceutical Formulations by HPLC Method’, Chromatographia, 2011; 74(7-8): 549-558
- Ricci C., Eliasson C., Macleod N.A., Newton P.N., Matousek P. and Kazarian S.G., ‘Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs’, Anal.&Bioanal.Chem. 2007; 389(5): 1525-1532
- Ricci C., Nyadong L., Fernandez F.M., Newton P.N. and Kazarian S.G., ‘Combined Fourier-transform desorption electrospray-ionization linear ion- trap mass spectrometry for analysis of counterfeit antimalarial tablets’, Analytical &Bioanalytical Chemistry, 2007; 387(2): 551-559 imaging and Green M.D., Nettey H., Villalva Rojas Ofelia,
- Pamanivong C., Khounsaknalath L., Ortiz M.G., Vongsack L. and OtManolin, ‘Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality’, J. of Pharm.& Biomed. Anal., 2007; 43(1): 105-110 Fernández F.M.,
- Dowell F.E., Maghirang Elizabeth B., Fernandez F.M., Newton P.N. and Green M.D., ‘Detecting counterfeit antimalarial tablets by near-infrared spectroscopy’, J.of Pharm.& Biomed. Anal., 2008; 48(3): 1011- 1014
- Patient Information Sheet Viagra®, US. Department of Health and Human Services, Food RockvilleMD, USA, June 2005. Administration,
- Lindegårdh N., Hien T.T., Farrar J., Singhasivanon P., White N.J. and Day N.P.J., ‘A simple and rapid liquid chromatographic assay for evaluation of potentially counterfeit Tamiflu®’, J. of Pharm.& Biomed. Anal., 2006; 42(4): 430-433
- Vredenbregt M.J., Blok-Tip L., Hoogerbrugge R., Barends D.M. and de Kaste D., ‘Screening suspected counterfeit Viagra® and imitations of Viagra® with near-infrared spectroscopy’, J. of Pharm.& Biomed. Anal., 2006; 40: 840–849.
- Zhou P., Oh S.S.Y., Hou P.L., Low M.Y. and Koh H.L., ‘Simultaneous determination of synthetic found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode chromatography–electrospray tandem mass spectrometry’, J. Chromatogr. A, 2006; 1104: 113–122. inhibitors array and liquid ionization
- Maurin J.K., Pluciński F., Mazurek A.P. and FijałekZbigniew, ‘The usefulness of simple X-ray counterfeit control—The Viagra® example’, J. of Pharm.& Biomed. Anal., 2007; 43(4): 1514-1518 analysis for de Veij M., Deneckere A., Vandenabeele P., de Kaste D. and Moens L., ‘Detection of counterfeit spectroscopy’, J.of Pharm.& Biomed. Anal., 2008; 46(2): 303-309 with Raman
- Sacré P.Y., Deconinck E., Saerens L., De Beer T., Courselle P., Vancauwenberghe R., Chiap P., Crommen J. and De Beer J.O., ‘Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis’, J.of Pharm.& Biomed. Anal., 2011; 56(2): 454-461
- Sacré P.Y., Deconinck E., De Beer T., Courselle P., Vancauwenberghe R., Chiap Patrice, Crommen J. and De Beer J.O., ‘Comparison spectroscopic techniques for the detection of of counterfeit Biomed. Anal., 2010; 53(3): 445-453 J.of Pharm.&
- Xie L-G., Sun H-M. and Jin S-H., ‘Screening adulteration of polypropylene bottles with postconsumer recycled plastics for oral drug package by near-infrared spectroscopy’, Anal.Chim.Acta, 2011; 706(2): 312-320
- Causin V., Marega C., Carresi P., Schiavone S. and differentiation method for plastic bags by infrared spectroscopy, thickness measurement and differential scanning calorimetry for tracing the source of illegal drugs’, Forensic Science International, 2006; 164(2-3): 148- 154 ‘A quantitative de Carvalho L.M., Martini M., Moreira P. A.
- L., de Lima A.P.S., Correia Daniele, Falcão Tatiana, Garcia Solange C., de Bairros A.V., do Nascimento P.C. and Bohrer Denise, Presence of synthetic pharmaceuticals as adulterants in slimming phytotherapeutic formulations determination, International, 2011; 204(1-3): 6-12 analytical Science Forensic
- Zou H-B., Yang G-S., Qin Z.Q. , Jiang W.Q., Ai Qin Du and AboulEnein H.Y., Progress in Quality Control of Herbal Medicine with IR Fingerprint Spectra, Anal.Lett., 2005; 38(9): 1457-1475
- Bunaciu A.A., Aboul-Enein H.Y. and Fleschin S., Recent Applications of Fourier Transform Infrared Spectrophotometry in Herbal Spectroscopy Reviews 2011; 46(4): 251-260 Applied
- Yap K.Y-L.., Chan S.Y. and Lim C.S., Infrared-based protocol for the identification and categorization of ginseng and its products, Food Research International, 2007: 40(5): 643-652
- Vardin H., Abdullatif T., OzenB.andMauer L., Authentication of pomegranate juice concentrate using FTIR spectroscopy and chemometrics, 108(2): 742-748 2008;
- Zhang L. and Nie L., Discrimination of geographical origin and adulteration of radix astragali using fourier transform infrared spectroscopy and chemometric methods, Phytochemical Analysis 2010; 21(6): 609– 615
- Zou P., Hong Y. and Koh H.L., Chemical fingerprinting of Isatisindigotica root by RP- HPLC and hierarchical clustering analysis, J. of Pharm.& Biomed. Anal., 2005; 38(3): 514-520
- Xie P., Chen S., Liang Y-Z., Wang X., Tian R. and Upton R., Chromatographic fingerprint analysis—a rational approach for quality assessment of traditional Chinese herbal medicine, 2006;1112(1-2): 171-180 A,
- Xie G. X., Qiu M. F., Zhao A. H. and Jia W., Fingerprint Analysis of FlosCarthami by Pressurized CEC and LC, Chromatographia, 2006; 64(11-12): 739-743
- Chen C., Zhang H., Xiao W., Yong Z-P. and Bai chromatographic fingerprint analysis for different origins of sea buckthorn berries, J. of Chromatography A, 2007; 1154(1-2): 250- 259 liquid
- Liang Y., Xie P. and Chau F., Chromatographic fingerprinting and related chemometric techniques for quality control of traditional Separation Science 2010; 33(3): 410–421 J. of
- Qiao X., Han J., He W-N., Wu T., Wang B- R., Ye M. and Guo D-A., ‘Chemical fingerprint of commercial Radix Echinopsis and quantitative analysis of α-terthienyl’, J.of Separation Science 2010; 33(4-5): 530–538
- Hu L.F., Li S.P., Cao H., Liu J.J., Gao J.L., Yang F.Q. and Wang Y.T., ‘GC–MS fingerprint of Pogostemoncablin in China’, J. of Pharm.& Biomed. Anal., 2006; 42(2): 200-206
- Marchei E., Pichini S., Pacifici R., Pellegrini M. and Zuccaro P., ‘A rapid and simple procedure for the determination of synephrine in chromatography-mass spectrometry’, J. of Pharm.&Biomed.Anal., 2006; 41(4): 1468- 1472 by gas
- Lucio-Gutiérrez J.R., Coello J. and Maspoch S., ‘Application of near infrared spectral fingerprinting techniques Eleutherococcussenticosus’, Food Research International, 2011; 44(2): 557-565 of
- Nicoletti M. and Petitto V., ‘Contaminations of herbal products determined by NMR fingerprint’, Natural Product Research, 2010; 24(14): 1325-1329
- Sombra L. L., Gómez M. R., Olsina R., Martínez L. D. and Silva M. F., ‘Comparative study between capillary electrophoresis and high performance liquid chromatography in ‘guarana’ based phytopharmaceuticals’,J.of Pharm. & Biomed . Anal ., 2005; 36(5): 989- 994
- Sze S. C-W., Song J-X., Wong R-N-S., Feng Y-B., Ng T-B.,Tong Y. and Zhang K.Y-B., ‘Application characterized amplified region) analysis to authenticate Lyciumbarbarum (wolfberry) and its adulterants’, Biotechnology & Applied Biochemistry, 2008; 51(1): 15–21 (sequence
- Kiran U., Khan S., Mirza K.J., Ram M. and Abdin M.Z., SCAR markers: ‘A potential tool for Fitoterapia, 2010; 81(8): 969-976 herbal drugs’,
- Li M., Jiang R-W., Hon P-M., Cheng L., Li L-L., Zhou J-R., Shaw P-C. and But P.P-H., ‘Authentication of the anti-tumor herb Baihuasheshecao with bioactive compounds and molecular sequences’, Food Chemistry, 2010; 119(3): 1239-1245 marker
- Zou P., Hong Y. and Koh H.L., ‘Chemical fingerprinting of Isatisindigotica root by RP- HPLC and hierarchical clustering analysis’, J. of Pharm.&Biomed.Anal., 2005; 38(3): 514- 520
- Li W., and Fitzloff, J.F., ‘HPLC analysis of ginsenosides in the roots of Asian ginseng (Panax ginseng) and North American ginseng (Panaxquinquefolius) with in-line photodiode array detection’. J. of Liquid Chromatography and Related Technologies, 2002; 25(1): 29–41.
- Kevin Y-L.Y., Chan S.Y. and Chu Lim C.S., of Authentication medicine distinguishing between ginseng and its morphological fakes, J. of Biomedical Science, 2007; 14(2): 265-273 Chinese using infrared spectroscopy:
- Edwards H.G.M., Munshi T. and Page K., Analytical discrimination between sources of ginseng Analytical &Bioanalytical Chemistry, 2007; 389(7-8): 2203-2215 spectroscopy,
- Li Li, Guo-An Luo, Qiong-Lin Liang, Ping Hu and Yi-Ming Wang, Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS, J.of Pharm.& Biomed. Anal., 2010; 52(1): 66-72
- Nelson L., Shih R. and Hoffman R., Aplastic anemia induced by adulterated herbal medication, J. Toxicol. Clin. Toxicol. 1995; 33: 467–470. de Carvalho L.M., Martini M., Moreira A. P.,
- Garcia S. C., do Nascimento P.C. and Denise B., pharmaceuticals in phytotherapeutics by capillary contactless conductivity detection (CZE- C4D), Microchemical Journal, 2010; 96(1): 114-119 of synthetic zone electrophoresis with
- VermaakI., Hamman J.H. and Viljoen A.M., High performance thin layer chromatography as a method to authenticate Hoodia gordonii raw material and products, South African Journal of Botany, 2010; 76(1): 119-124
- Wang J., Chen B. and Yao S., Analysis of six synthetic adulterants in herbal weight- reducing electrospray ionization-MS, Food Additives & Contaminants: Part A, 2008; 25(7): 822- 830 by LC
- Zhang J., Zhang X., Dediu L., Cristea V., Review of the current application of fingerprinting allowing detection of food adulteration and fraud in China, Food Control, 2011; 22(8): 1126-1135
- Reepmeyer J.C. and Woodruff J.T., Use of liquid chromatography–mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a “natural” herbal dietary supplement, J.of Chromatography A, 2006; 1125(1): 67-75 Gryniewicz C. M.,
- Kauffman J.F. and Buhse L. F., ‘Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility Biomed. Anal., 2009; 49(3): 601-606 J.C., J.of Pharm.&
- Singh S., Prasad B. , SavaliyaA.A.,Shah R.P.,. Gohil V.M. and Kaur A., Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, products containing these drugs, TrAC Trends in Analytical Chemistry, 2009, 28(1), 13-28 counterfeit
- Bombardelli, E., Mustich, G., and Bertani, M. (1989). New extracts of Ginkgo biloba and their methods of preparation. European patent 89309500.0 – A61K 35/78.
- Chandra A., Li Y., Rana J., Persons K., Hyun C., Shen S. and Mulder T., Qualitative categorization of supplement grade Ginkgo biloba leaf extracts for authenticity, J. of Functional Foods, 2011; 3(2): 107-114
- Rohman A. and Che Man Y.B., Fourier transform infrared (FTIR) spectroscopy for analysis of extra virgin olive oil adulterated with palm oil, Food Research International, 2010; 43(3): 886-892
- Balasubramani S.P. , Goraya G.S. and Venkatasubramanian P., Development of ITS sequence-based Berberisaristata DC. from B. lyciumRoyle and B. asiaticaRoxb., 3 Biotech, 2011; 1(1): 11-19 to distinguish