NRF2'nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü

İslim Kaleler; İlhan Yaylım

doi:10.46373/hafebid.1442953

NRF2'nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü

Abstract

Nükleer Faktör Eritroid 2 ile İlişkili Faktör 2 (NRF2), hücrede başlıca oksidatif hasara karşı koruyucu olmakla birlikte metabolizmanın düzenlenmesinde de rolü olan transkripsiyon faktörüdür ve hücresel redoks dengesinin sağlanmasında merkezi rol oynar. Kanserin tedavisi için anahtar mekanizmalardan birisi NRF2 yolağıdır. NRF2-KEAP1 yolağının koruyucu rolleri göz önüne alındığında, aktivasyonunun bir dizi antioksidan mekanizmayı destekleyerek kanser oluşumunu etkili bir şekilde önleyebileceğini düşündürmektedir. Bu nedenle NRF2’nin kanser gelişimindeki ve ilerlemesindeki rolleri yoğun bir şekilde araştırılmaktadır. Başlangıçta kansere karşı koruyucu olduğu ortaya konmasına rağmen, günümüzde kanseri desteklediği de bulunmuştur. Kanserde umut verici terapötik bir hedef olarak görülmekte ve oynadığı “iki yönlü” rolden dolayı NRF2’nin hem aktivatörleri hem de inhibitörleri giderek artan ilgi çekici bir araştırma alanı olmaktadır.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Metabolomic Chemistry

Journal Section

Research Article

Authors

İslim Kaleler ^*
0000-0002-2712-7955
Türkiye

İlhan Yaylım
0000-0003-2615-0202
Türkiye

Publication Date

March 30, 2024

Submission Date

February 26, 2024

Acceptance Date

March 26, 2024

Published in Issue

Year 2024 Volume: 7 Number: 1

DOI

https://doi.org/10.46373/hafebid.1442953

IZ

https://izlik.org/JA36XB77EP

Cite

RIS / Bibtex

APA

Kaleler, İ., & Yaylım, İ. (2024). NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü. Haliç Üniversitesi Fen Bilimleri Dergisi, 7(1), 1-16. https://doi.org/10.46373/hafebid.1442953

AMA

1.Kaleler İ, Yaylım İ. NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü. Natural Sciences - General. 2024;7(1):1-16. doi:10.46373/hafebid.1442953

Chicago

Kaleler, İslim, and İlhan Yaylım. 2024. “NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu Ve Teşvik Edici Rolü”. Haliç Üniversitesi Fen Bilimleri Dergisi 7 (1): 1-16. https://doi.org/10.46373/hafebid.1442953.

EndNote

Kaleler İ, Yaylım İ (March 1, 2024) NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü. Haliç Üniversitesi Fen Bilimleri Dergisi 7 1 1–16.

IEEE

[1]İ. Kaleler and İ. Yaylım, “NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü”, Natural Sciences - General, vol. 7, no. 1, pp. 1–16, Mar. 2024, doi: 10.46373/hafebid.1442953.

ISNAD

Kaleler, İslim - Yaylım, İlhan. “NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu Ve Teşvik Edici Rolü”. Haliç Üniversitesi Fen Bilimleri Dergisi 7/1 (March 1, 2024): 1-16. https://doi.org/10.46373/hafebid.1442953.

JAMA

1.Kaleler İ, Yaylım İ. NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü. Natural Sciences - General. 2024;7:1–16.

MLA

Kaleler, İslim, and İlhan Yaylım. “NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu Ve Teşvik Edici Rolü”. Haliç Üniversitesi Fen Bilimleri Dergisi, vol. 7, no. 1, Mar. 2024, pp. 1-16, doi:10.46373/hafebid.1442953.

Vancouver

1.İslim Kaleler, İlhan Yaylım. NRF2’nin İkili Doğası: Kanser Gelişiminde Koruyucu ve Teşvik Edici Rolü. Natural Sciences - General. 2024 Mar. 1;7(1):1-16. doi:10.46373/hafebid.1442953