Investigation of Biochemical Properties of Acetone O-(4-chlorophenylsulfonyl)oxime and Acetone O-(2-naphthylsulfonyl)oxime

Year 2024, Volume: 1 Issue: 1, 7 - 11, 26.04.2024

Pınar Yalçın Abdurrahman Dündar Veysi Okumuş

https://doi.org/10.5281/zenodo.11068908

Abstract

The purpose of this study is to survey if acetone O-(4 chlorophenylsulfonyl) oxime and acetone O-(2-naphtylsülphonyl)oxime compounds have antimicrobial and antioxidant properties or not. For this purpose, the antioxidant activity of the compounds was tested using the DPPH free radical method and the method of determining the antibacterial activity of newly synthesized compounds. As a result, compound 1a shows better antioxidant activity than compound 2a at all tested concentrations. The antibacterial activities of sulfonate derivatives on Staphylococcus aureus, Bacillus sps, Escherichia coli, and Klebsiella pneumoniae strains were investigated and it was determined that all compounds showed partial antibacterial activity for S. aureus, E. coli, and K. pneumoniae strains.

Keywords

Acetone O-(4-chlorophenylsulfonyl)oxime, Acetone O-(2-naphtylsülphonyl)Oxime, Antimicrobial activity, Antioxidant activity, Docking, ADMET

Aseton O-(4-klorofenilsülfonil)oksim ve Aseton O-(2-naftilsülfonil)oksimin Biyokimyasal Özelliklerinin Araştırılması

Abstract

Bu çalışmanın amacı, aseton O-(4 klorofenilsülfonil) oksim ve aseton O-(2-naftilsülfonil)oksim bileşiklerinin antimikrobiyal ve antioksidan özelliklere sahip olup olmadığını araştırmaktır. Bu amaçla bileşiklerin antioksidan aktiviteleri DPPH serbest radikal yöntemi ile antioksidan ve antibakteriyel aktivitelerinin belirlenmiştir. Sonuç olarak bileşik 1a, test edilen tüm konsantrasyonlarda bileşik 2a'dan daha iyi antioksidan aktivite gösterir. Sülfonat türevlerinin Staphylococcus aureus, Bacillus sps, Escherichia coli ve Klebsiella pneumoniae suşları üzerindeki antibakteriyel aktiviteleri araştırılmış ve tüm bileşiklerin S. aureus, E. coli ve K. pneumoniae suşlarına karşı kısmi antibakteriyel aktivite gösterdiği tespit edilmiştir.

Keywords

Aseton, Aseton oksim, Antimikrobiyal aktivite, Antioksidan aktivite, Docking, ADMET

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