Glutathione in Health and Disease: A Comprehensive Review of Its Physiological Roles and Clinical Applications
Abstract
In recent years, glutathione (GSH) has been intensively researched for its potential effects in the fields of health and beauty. Glutathione is a tripeptide that performs vital functions in the body such as reducing oxidative stress, maintaining redox balance, metabolic detoxification and regulating the immune system. Suboptimal glutathione levels have been associated with various health problems such as neurodegenerative diseases, cancer and diabetes. This review addresses the biological role of glutathione and its health implications, and discusses the benefits and potential side effects of glutathione supplements in clinical situations. The synthesis of glutathione can be promoted by sulfur-rich foods and supplements can be effective in the treatment of various clinical diseases. However, it is important to take glutathione supplements in the correct dose and with the appropriate method. High doses or incorrect methods can lead to unwanted side effects. Furthermore, more reliable methods for measuring glutathione levels need to be developed. In the future, it is important to conduct more comprehensive studies to investigate the long-term effects of glutathione.
Keywords
Glutathione oxidative stress metabolic detoxification immune system glutathione supplementation
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Details
| Primary Language | English |
|---|---|
| Subjects | Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry |
| Journal Section | Review Article |
| Authors | |
| Submission Date | April 30, 2025 |
| Acceptance Date | December 2, 2025 |
| Publication Date | January 31, 2026 |
| Published in Issue | Year 2026 Volume: 3 Issue: 1 |
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Falsifying research records and obtained data, presenting methods, devices and materials that were not used in the research as if they were used, not taking into consideration data that do not comply with the research hypothesis, tampering with data and/or results to fit the relevant theory or assumptions, using research results in line with the interests of the people and organizations receiving support. To distort or shape.
Protection of Participants' Personal Data
Hittite Journal of Science requires that all research involving personal or sensitive data or material regarding human participants that is not legally available to the public be subject to formal ethical review.
Handling Allegations of Research Misconduct
Hitit Journal of Science is a Successful Editorial of COPE
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No fee is charged to the author or institution under any name. The article submission and evaluation process is free.
Hitit Journal of Science does not charge any fee for the publication of an article. All articles are open access free of charge.
All expenses of Hitit Journal of Science are covered by Hitit University. Hitit Journal of Science does not accept any advertising or sponsor support.
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Editor-in-Chief
Dursun Ali KÖSE was born in Samsun Terme. He completed his undergraduate and graduate studies at Kars Kafkas University, Department of Chemistry, with his thesis titled "Synthesis of Nicotinamide and Diethylnicotinamide Complexes of Acetylsalicylates and Investigation of their Structures". Doctor title: Prof. Dr. He received his thesis title "Preparation and Structure Investigation of Biopotent Boron Compounds with Hydroxy-Functionalized Organic Molecules" at Hacettepe University, Department of Inorganic Chemistry, under the supervision of Birgül KARAN in 2008. Between 2009 and 2010, he worked as Research Assistant at Kafkas University, Department of Chemistry. See Dr. After working as an assistant at Çorum Hitit University, Department of Chemistry. Assoc. Dr. was appointed as. In 2010, for postdoctoral studies, Prof. Dr. It was found in Mike Becket's laboratories at the Bangor/Wales School of Chemistry. He received the title of Associate Professor at Hitit University in 2013 and the title of Professor at the same University in 2018.
Köse has around 140 scientific articles scanned by international indexes, around 90 papers presented at international conferences, and his studies on metal complexes and boron esters of biologically active ligands continue. He also has studies in the fields of Environment and Waste Management and Occupational Health and Safety.
Section Editors
Güner SAKA was born in Tokat. He completed his undergraduate and graduate studies at Anadolu University, Department of Chemistry, with his thesis titled "Biotechnological removal of phenolics". Doctor title: Dr. He received his thesis title "Synthesis of RGD based polymers and cell interaction studies " at Eskişehir Technical University, Department of Analytical Chemistry, under the supervision of Arzu ERSÖZ in 2022. Between 2005 and 2010, he worked as Part time student at Anadolu University, Medicinal Plants, Drugs and Scientific Research Centre. See Dr. After working as an specialist at Çorum Hitit University, Department of Chemistry.
Associate Editors
Güner SAKA was born in Tokat. He completed his undergraduate and graduate studies at Anadolu University, Department of Chemistry, with his thesis titled "Biotechnological removal of phenolics". Doctor title: Dr. He received his thesis title "Synthesis of RGD based polymers and cell interaction studies " at Eskişehir Technical University, Department of Analytical Chemistry, under the supervision of Arzu ERSÖZ in 2022. Between 2005 and 2010, he worked as Part time student at Anadolu University, Medicinal Plants, Drugs and Scientific Research Centre. See Dr. After working as an specialist at Çorum Hitit University, Department of Chemistry.