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Year 2015, , 165 - 171, 30.12.2015
https://doi.org/10.17350/HJSE19030000021

Abstract

References

  • Kenawy E-R, Kamoun EA, Mohy Eldin MS, El-Meligy MA. Physically crosslinked poly(vinyl alcohol)-hydroxyethyl starch blend hydrogel membranes: Synthesis and characterization for biomedical applications. Arabian J.Chem. 7 (2014) 372-380.
  • Hassan C, Peppas N, Structure and Applications of Poly(vinyl alcohol) Hydrogels Produced by Conventional Crosslinking or by Freezing/Thawing Methods, Biopolymers PVA Hydrogels, Anionic Polymerisation Nanocomposites, Springer Berlin Heidelbergpp. 37-65, 2000.
  • Smith TJ, Kennedy JE, Higginbotham CL. The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications. J.Mech.Behav.Biomed.Mater. 2 (2009) 264- 271.
  • Hua S, Ma H, Li X, Yang H, Wang A. pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol. 46 (2010) 517-523.
  • Xiao C, Yang M. Controlled preparation of physical cross- linked starch-g-PVA hydrogel. Carohydr.Polym. 64 (2006) 37-40.
  • Kim JO, Park JK, Kim JH, Jin SG, Yong CS, Li DX, Choi JY, Woo JS, Yoo BK, Lyoo WS, Kim J-A, Choi H-G. Development of polyvinyl alcohol–sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. Int.J.Pharma. 359 (2008) 79-86.
  • Gonzalez JS, Alvarez VA. Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage. J.Mech.Behav.Biomed.Mater. 34 (2014) 47-56.
  • Kamoun EA, Chen X, Mohy Eldin MS, Kenawy E-RS. Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: A review of remarkably blended polymers. Arabian J.Chem. 8 (2015) 1-14.
  • Oun R, Plumb JA, Wheate NJ. A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol. J.Inorg.Biochem. 134 (2014) 100-105.
  • Baker MI, Walsh SP, Schwartz Z, Boyan BD. A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. J.Biomed.Mater.Res.Part B Appl.Biomater. 100B (2012) 1451-1457.
  • Mandal TK. Swelling-controlled release system for the vaginal delivery of miconazole. Eur.J.Pharma.Biopharma. 50 (2000) 337-343.
  • Sawhney AS, Pathak CP, Hubbell JA. Interfacial photopolymerization of poly(ethylene glycol)-based hydrogels upon alginate-poly(l-lysine) microcapsules for enhanced biocompatibility. Biomaterials. 14 (1993) 1008- 1016.
  • Smith T, Kennedy J, Higginbotham C. Development of a novel porous cryo-foam for potential wound healing applications. J.Mater.Sci: Mater.Med. 20 (2009) 1193-1199.
  • Khoee S, Kardani M. Preparation of PCL/PEG superporous hydrogel containing drug-loaded nanoparticles: The effect of hydrophobic–hydrophilic interface on the physical properties. Eur.Polym.J. 58 (2014) 180-190.
  • Mansur HS, Oréfice RL, Mansur AAP. Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy. Polymer. 45 (2004) 7193-7202.
  • Hassan CM, Peppas NA. Structure and Morphology of Freeze/Thawed PVA Hydrogels. Macromol. 33 (2000) 2472-2479.
  • Park KR, Nho YC. Synthesis of PVA/PVP hydrogels having two-layer by radiation and their physical properties. Radiat. Phys.Chem. 67 (2003) 361-365.
  • Özkahraman B, Acar I, Emik S. Removal of cationic dyes from aqueous solutions with poly (N-isopropylacrylamide- co-itaconic acid) hydrogels. Polymer Bulletin. 66 (2011) 551-570.
  • Srivastava A, Jain E, Kumar A. The physical characterization of supermacroporous poly(N-isopropylacrylamide) cryogel: Mechanical strength and swelling/de-swelling kinetics. Materials Science and Engineering: A. 464 (2007) 93-100.
  • Kathuria N, Tripathi A, Kar KK, Kumar A. Synthesis and characterization of elastic and macroporous chitosan– gelatin cryogels for tissue engineering. Acta Biomaterialia. 5 (2009) 406-418.
  • Dalaran M, Emik S, Güçlü G, İyim TB, Özgümüş S. Study on a novel polyampholyte nanocomposite superabsorbent hydrogels: Synthesis, characterization and investigation of removal of indigo carmine from aqueous solution. Desalination. 279 (2011) 170-182.
  • Wang J, Wu W, Lin Z. Kinetics and thermodynamics of the water sorption of 2-hydroxyethyl methacrylate/styrene copolymer hydrogels. J. Appl. Polym. Sci. 109 (2008) 3018-3023.
  • [32]Deen GR, Chua V, Ilyas U. Synthesis, swelling properties, and network structure of new stimuli-responsive poly(N- acryloyl-N′-ethyl piperazine-co-N-isopropylacrylamide) hydrogels. J.Polym.Sci.PartA:Polym.Chem. 50 (2012) 3363-3372.
  • Ganji F, Vasheghani-Farahani S, Vasheghani-Farahani E. Theoretical description of hydrogel swelling: a review. Iran Polym J. 19 (2010) 375-398.
  • [34]Ostrowska-Czubenko J, Gierszewska M, Pieróg M. pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling. J Polym Res. 22 (2015) 1-12.
  • Peppas NA, Tennenhouse D. Semicrystalline poly(vinyl alcohol) films and their blends with poly(acrylic acid) and poly(ethylene glycol) for drug delivery applications. Journal of Drug Delivery Science and Technology. 14 (2004) 291- 297.
  • Ricciardi R, Auriemma F, De Rosa C, Lauprêtre F. X-ray Diffraction Analysis of Poly(vinyl alcohol) Hydrogels, Obtained by Freezing and Thawing Techniques. Macromol. 37 (2004) 1921-1927.

Potential evaluation of PVA-based hydrogels for biomedical applications

Year 2015, , 165 - 171, 30.12.2015
https://doi.org/10.17350/HJSE19030000021

Abstract

P oly vinyl alcohol PVA -based hydrogels prepared using freeze/thawing treatment have become increasingly important biomaterials for biomedical applications having great properties such as biocompatibility, biodegradability and high water absorbency. In this study, PVA-based physically cross-linked hydrogels were prepared with and without the presence of poly ethylene glycol PEG freezing at -16 °C for 16 h and thawing at room temperature for 8 h. The focus of this work was to address the effect of the addition of PEG Mw: 2000 or 5000 and the effect of the number of freezing/thawing cycles on swelling behaviour. The Scanning Electron Microscopy SEM measurements demonstrated the morphological characteristics of PVA-based hydrogels indicating the formation of the macroporosity fabricated during freeze/thawing process. From the swelling tests undertaken it w as apparent that all the hydrogels exhibited unique swelling characteristics having high swelling degree at all pH values such as pH 2.1, 5.5 and 7.4 representing the pH values of stomach, blood and dermis. Thus, the hydrogels synthesized in this study present important potential for biomedical applications

References

  • Kenawy E-R, Kamoun EA, Mohy Eldin MS, El-Meligy MA. Physically crosslinked poly(vinyl alcohol)-hydroxyethyl starch blend hydrogel membranes: Synthesis and characterization for biomedical applications. Arabian J.Chem. 7 (2014) 372-380.
  • Hassan C, Peppas N, Structure and Applications of Poly(vinyl alcohol) Hydrogels Produced by Conventional Crosslinking or by Freezing/Thawing Methods, Biopolymers PVA Hydrogels, Anionic Polymerisation Nanocomposites, Springer Berlin Heidelbergpp. 37-65, 2000.
  • Smith TJ, Kennedy JE, Higginbotham CL. The rheological and thermal characteristics of freeze-thawed hydrogels containing hydrogen peroxide for potential wound healing applications. J.Mech.Behav.Biomed.Mater. 2 (2009) 264- 271.
  • Hua S, Ma H, Li X, Yang H, Wang A. pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol. 46 (2010) 517-523.
  • Xiao C, Yang M. Controlled preparation of physical cross- linked starch-g-PVA hydrogel. Carohydr.Polym. 64 (2006) 37-40.
  • Kim JO, Park JK, Kim JH, Jin SG, Yong CS, Li DX, Choi JY, Woo JS, Yoo BK, Lyoo WS, Kim J-A, Choi H-G. Development of polyvinyl alcohol–sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. Int.J.Pharma. 359 (2008) 79-86.
  • Gonzalez JS, Alvarez VA. Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage. J.Mech.Behav.Biomed.Mater. 34 (2014) 47-56.
  • Kamoun EA, Chen X, Mohy Eldin MS, Kenawy E-RS. Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: A review of remarkably blended polymers. Arabian J.Chem. 8 (2015) 1-14.
  • Oun R, Plumb JA, Wheate NJ. A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol. J.Inorg.Biochem. 134 (2014) 100-105.
  • Baker MI, Walsh SP, Schwartz Z, Boyan BD. A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. J.Biomed.Mater.Res.Part B Appl.Biomater. 100B (2012) 1451-1457.
  • Mandal TK. Swelling-controlled release system for the vaginal delivery of miconazole. Eur.J.Pharma.Biopharma. 50 (2000) 337-343.
  • Sawhney AS, Pathak CP, Hubbell JA. Interfacial photopolymerization of poly(ethylene glycol)-based hydrogels upon alginate-poly(l-lysine) microcapsules for enhanced biocompatibility. Biomaterials. 14 (1993) 1008- 1016.
  • Smith T, Kennedy J, Higginbotham C. Development of a novel porous cryo-foam for potential wound healing applications. J.Mater.Sci: Mater.Med. 20 (2009) 1193-1199.
  • Khoee S, Kardani M. Preparation of PCL/PEG superporous hydrogel containing drug-loaded nanoparticles: The effect of hydrophobic–hydrophilic interface on the physical properties. Eur.Polym.J. 58 (2014) 180-190.
  • Mansur HS, Oréfice RL, Mansur AAP. Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy. Polymer. 45 (2004) 7193-7202.
  • Hassan CM, Peppas NA. Structure and Morphology of Freeze/Thawed PVA Hydrogels. Macromol. 33 (2000) 2472-2479.
  • Park KR, Nho YC. Synthesis of PVA/PVP hydrogels having two-layer by radiation and their physical properties. Radiat. Phys.Chem. 67 (2003) 361-365.
  • Özkahraman B, Acar I, Emik S. Removal of cationic dyes from aqueous solutions with poly (N-isopropylacrylamide- co-itaconic acid) hydrogels. Polymer Bulletin. 66 (2011) 551-570.
  • Srivastava A, Jain E, Kumar A. The physical characterization of supermacroporous poly(N-isopropylacrylamide) cryogel: Mechanical strength and swelling/de-swelling kinetics. Materials Science and Engineering: A. 464 (2007) 93-100.
  • Kathuria N, Tripathi A, Kar KK, Kumar A. Synthesis and characterization of elastic and macroporous chitosan– gelatin cryogels for tissue engineering. Acta Biomaterialia. 5 (2009) 406-418.
  • Dalaran M, Emik S, Güçlü G, İyim TB, Özgümüş S. Study on a novel polyampholyte nanocomposite superabsorbent hydrogels: Synthesis, characterization and investigation of removal of indigo carmine from aqueous solution. Desalination. 279 (2011) 170-182.
  • Wang J, Wu W, Lin Z. Kinetics and thermodynamics of the water sorption of 2-hydroxyethyl methacrylate/styrene copolymer hydrogels. J. Appl. Polym. Sci. 109 (2008) 3018-3023.
  • [32]Deen GR, Chua V, Ilyas U. Synthesis, swelling properties, and network structure of new stimuli-responsive poly(N- acryloyl-N′-ethyl piperazine-co-N-isopropylacrylamide) hydrogels. J.Polym.Sci.PartA:Polym.Chem. 50 (2012) 3363-3372.
  • Ganji F, Vasheghani-Farahani S, Vasheghani-Farahani E. Theoretical description of hydrogel swelling: a review. Iran Polym J. 19 (2010) 375-398.
  • [34]Ostrowska-Czubenko J, Gierszewska M, Pieróg M. pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling. J Polym Res. 22 (2015) 1-12.
  • Peppas NA, Tennenhouse D. Semicrystalline poly(vinyl alcohol) films and their blends with poly(acrylic acid) and poly(ethylene glycol) for drug delivery applications. Journal of Drug Delivery Science and Technology. 14 (2004) 291- 297.
  • Ricciardi R, Auriemma F, De Rosa C, Lauprêtre F. X-ray Diffraction Analysis of Poly(vinyl alcohol) Hydrogels, Obtained by Freezing and Thawing Techniques. Macromol. 37 (2004) 1921-1927.
There are 27 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Emel Tamahkar This is me

Bengi Özkahraman This is me

Publication Date December 30, 2015
Published in Issue Year 2015

Cite

Vancouver Tamahkar E, Özkahraman B. Potential evaluation of PVA-based hydrogels for biomedical applications. Hittite J Sci Eng. 2015;2(2):165-71.

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